[PDF] Top 20 Vasoactive intestinal peptide in human nasal mucosa

... submucosal glands adjacent to serous and mucous cells. 125I-VIP binding sites were located on submucosal glands, epithelial cells, and arterioles. In short-term explant culture, VIP stimulated lactoferrin release from ... See full document

... Vasoactive intestinal peptide (VIP), a major neurotransmit- ter of peripheral nerves, has been suggested to function in host defense by regulating local human immune ...in human Ig ... See full document

... Human subjects were treated pursuant to IND 52,088 under a protocol approved by the Institutional Review Board of State University of New York Health Sciences Center, Stony Brook, NY. Patients who met the ... See full document

... Vasoactive intestinal peptide (VIP) has a broad range of biological actions such as dilatation of smooth muscle cells including broncho- and vasodilation, insulin releasing properties, influence on ... See full document

... maximal inhibition was observed at 2 nM. Scatchard analysis indicated two functionally independent classes of receptor sites: 62,000 high affinity sites/cell with a dissociation constant (K d ) of 1.3 nM, and 510,000 low ... See full document

... Vasoactive intestinal peptide (VIP) is a linear 28-amino-acid peptide with molecular weight of 3,326 Da that is generated by enzymatic cleavage from its precursor molecule, ...of ... See full document

... the human body, the vasoactive intestinal peptide (VIP) shows striking pharmacological characteristics that might be worthy of testing for its ability in combating ... See full document

... the nasal mucosa of rats through inhalation to treat Alzheimer’s disease and found that the concentration of VIP in the brains of rats was similar to that found with direct intraventricular ...through ... See full document

... In the present study we have used a-chymotrypsin, LNMMA, and L-NAME to assess the modulatory effects of endogenous VIP and NO on functional cholinergic contractile responses to EFS at th[r] ... See full document

... In human pregnancy, the postimplantation period from approximately days 22 to 32 corresponds to the midgesta- tional period of the rodent and is the time span in which simi- lar developmental events occur in the ... See full document

... to hypoxic–ischemic mechanisms, seems to be multifactorial, involving several preconceptional and prenatal factors, possi- bly including hypoxia/perfusion failure, thyroid hormone defi- ciency, growth factor deficiency, ... See full document

... However, the most uncommon data obtained in the present studies was the finding of VIP-selective very high-affinity binding sites. The expression of VIP-selective high-affinity binding sites in glial cells (Brenneman et ... See full document

... also stimulates nuclear translocation of cytokine tran- scription factors (NFkB and c-JUN) and subsequent TNF-α production by human monocytes through the re- duction of LPS, and up-regulation of the TLR-2 and ... See full document

... between vasoactive intestinal peptide (VIP) and fraktalkine (FKN) in recruiting human mast cells to the asthmatic airway that provided a classical example of priming effect on mast cells ... See full document

... The mechanism of gp120-induced neurotoxicity is un- known. Earlier work from our laboratory indicated that gp120 acts indirectly to interfere with glial cell neurotrophic func- tions (16, 17). VIP stimulates the release ... See full document

... in nasal wash solutions VIP stability was evaluated in nasal wash solu- tions using a method adapted from Aungst and Phang ...the nasal wash solutions, three hypotonic (20 mOsm/kg) buffered solutions ... See full document

... measured by radioimmunoassay was 0.60 +/- 0.25 pmol/g tissue (n = 9 patients; mean +/- SEM). GRP-immunoreactive nerves detected by the immunogold method of indirect immunohistochemistry were found predominantly in small ... See full document

... ileal mucosa. In rabbit ileal mucosa, VIP (20 µg/ml) caused a prompt fivefold increase in cyclic AMP level, whereas nine other hormones, which have been postulated to cause intestinal secretion, ... See full document

... lymphocytes, mucosa of the stomach and small intestine, and many other tissues ...large intestinal mucosa, thyroid follicular cells, adrenal medulla, retina, and al- veolar ... See full document

... results in the suppression of small−intestinal and gallbladder motility and determines the periodic appearance of the migrating motor complex, while diversion of bile from the duodenum causes the opposite effect ... See full document