[PDF] Top 20 Viral modulators od KSHV lytic replication
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Viral modulators od KSHV lytic replication
... The KSHV genome includes core herpesviral genes, KSHV-specific genes and genes that are homologous to cellular ...These viral homologs have most likely been “stolen” from the host in what is referred ... See full document
185
Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
... on viral DNA during amplification of KSHV genomes in B ...of viral DNA at 24 and 48 h following doxycycline treatment relative to that for the 0-h controls ...during lytic replication of ... See full document
21
Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... MHV-68 lytic replication in vitro (11, ...for KSHV lytic replication, besides its antiapoptotic and antiau- tophagic ...of KSHV and M11 of MHV-68 have similar crystal structures, ... See full document
10
Development of an ORF45-Derived Peptide To Inhibit the Sustained RSK Activation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus
... The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) requires sustained extracellular signal-regulated kinase (ERK)-p90 ribosomal S6 kinase (RSK) activation, which is induced by an ... See full document
13
Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication
... nant KSHV (BAC36) were stimulated with PBS (placebo) or TPA (20 ng/ml) in the absence or presence of MA (1 M) or DAA (25 M) for 24 ...relative viral titer of the supernatant in ... See full document
21
Topoisomerase I and RecQL1 Function in Epstein-Barr Virus Lytic Reactivation
... and viral chromosome metabolism including DNA replication, recombination, and transcription (3, 22, ...EBV replication at concentrations that were not toxic to the host cell ...DNA replication ... See full document
9
Dissection of the Kaposi's Sarcoma-Associated Herpesvirus Gene Expression Program by Using the Viral DNA Replication Inhibitor Cidofovir
... for KSHV ORF 17 RNA. RNA was harvested at 72 h after the induction of lytic replication from BCBL-1 cells pretreated with 0, 10, 25, 50, 75, and 100 M ...for KSHV DNA after an initial DNase ... See full document
16
Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection
... regulating viral gene expression of a number of vi- ruses, including hepatitis B virus (HBV) (29), herpes simplex virus 1 (HSV-1) (30), human cytomegalovirus (HCMV) (31), and hu- man T-cell leukemia virus (HTLV) ... See full document
19
Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication
... with KSHV RTA (41) and functions as a repressor for RTA-mediated transactivation to negatively regulate RTA-mediated KSHV lytic replication in KSHV-infected cells ... See full document
14
NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target.
... The KSHV lytic cycle is intimately linked to the pathogenesis of KSHV malignancies and the role of NEDDylation or the importance of CRL-mediated ubiquitylation during this process is currently ...of ... See full document
26
Signaling Cascades Triggered by Bacterial Metabolic End Products during Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
... reactivate KSHV lytic replication using stress-activated path- ways, resulting in an increase in the release of virions, similar to that of physiological concentrations ...of KSHV reactivation ... See full document
11
Contribution of the KSHV and EBV lytic cycles to tumourigenesis
... by KSHV ORF16 shares sequence and functional homology to the Bcl-2 family of cellular pro- teins ...of KSHV, murine herpesvirus 68 (MHV68), have shown that vBcl-2 is involved in both the inhibition of ... See full document
11
Binding of Cellular Export Factor REF/Aly by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF57 Protein Is Not Required for Efficient KSHV Lytic Replication
... Although KSHV ORF57, EBV SM, and HSV ICP27 are re- quired for viral replication and interact with various cellular ex- port factors, it remains unclear whether these interactions are es- sential for ... See full document
9
Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-Associated Herpesvirus Replication and Is Targeted by a Viral Transcriptional Factor
... and lytic cycles of Kaposi’s sarcoma-associated herpesvirus (KSHV) is accompanied by specific alterations of histone ...of KSHV showed the deposition of H3K27me3 across the KSHV genome with ... See full document
11
Activation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by Inhibitors of Class III Histone Deacetylases: Identification of Sirtuin 1 as a Regulator of the KSHV Life Cycle
... and lytic replication phases are tightly associated with histone posttranslational ...regulate KSHV latent and lytic ...latently KSHV- infected cells into lytic ... See full document
13
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma
... blocks KSHV infectious virion production by UM-PEL-1c ...and viral lytic induction occur- ring in the absence of late lytic ...that lytic gene inhibition correlated with a lack of ... See full document
14
Activation of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Lytic Replication by Human Cytomegalovirus
... of viral proteins. For the immunofluorescence assay (IFA) detection of KSHV and HCMV, proteins in HF were grown on Lab-Tek Cham- ber slides (Nalge Nunc International), fixed with 4% paraformaldehyde for 30 ... See full document
9
Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... the lytic cycle in the newly infected ...early lytic gene ORF57 to quantify ...upon lytic reactivation of TREx-BCBL1-RTA, as evidenced by the appearance of cleaved forms of these caspases, and ... See full document
17
Epstein-Barr Virus Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication in Primary Effusion Lymphomas
... Induction of KSHV lytic replication. BC3 cells were treated with 5 to 10 ng/ml TPA for 18 to 24 h to induce lytic viral replication. For BC1 cells, 0.5 to 1 mM sodium butyrate ... See full document
11
Discovery of a Coregulatory Interaction between Kaposi's Sarcoma-Associated Herpesvirus ORF45 and the Viral Protein Kinase ORF36
... Although KSHV ORF36 has been shown to induce only mild disassembly of lamins after transient transfection (41), we suspect that its role during lytic replication is more ...the viral nuclear ... See full document
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