[PDF] Top 20 Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case control study

... Introduction Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer ...Whether risk is influenced by polymorphisms in other ... See full document

... on breast cancer risk factors and potential con- founders was ascertained from responses to biennial ques- tionnaires from the CPS-II ...individual vitamin D supplements from the brief ... See full document

... current study include the use of only one measure to assess exposure, the possibility that the exposure was not assessed during the relevant time period, a relatively short follow-up time, and the inability to ... See full document

... Our study adds to the literature by being the first study, to our knowledge, examining effect modification of MTHFR by multi- ple nutrients involved in the one-carbon metabolism pathway; data on ... See full document

... cant gene-environment interaction with family history of breast cancer, use of hormone therapy, or smoking ...Because vitamin D possibly exerts its anticarcinogenic activi- ties via the ... See full document

... this nested case-control study of postmenopausal breast cancer and patterns of estrogen metabolism, increased risks for individual EM were not observed except for ...while ... See full document

... this study include its prospective design, inclusion of two cohorts with different diet and sun expo- sure, and large sample ...first study to include repeat blood samples on a large number of ... See full document

... Blood Vitamin D Are Associated With a Higher Prostate Cancer Risk: a Longitudinal, Nested Case-Control Study in the Nordic ... See full document

... present study include its large size, gen- eralizability, and the ability to control for most of the estab- lished risk factors for breast ...largest study of VDR polymorphisms ... See full document

... among postmenopausal women, the minimum detectable OR ranged from ...this study is that HT use status assessed at baseline may have changed during ...this nested case-con- trol study) ... See full document

... VDR gene polymorphisms and cancers are ...VDR gene polymorphisms (FokI, BsmI, TaqI, ApaI and Cdx2) and the risk of different solid tumors in the skin, prostate, breast, colon, ... See full document

... between breast cancer risk and a number of tag SNPs in VDR without previously known ...reduced breast cancer risk in AA women, irre- spectively of ER ...VDR gene. This SNP ... See full document

... [63], risk of developing an adverse response to radiotherapy [19], as well as interaction with high intake of fruits and vegetables [33], and it could thus be hypothesized to affect breast cancer ... See full document

... this study should be ...the case-control ...and diet, were not included in this study, which may influence breast cancer ... See full document

... and vitamin D receptor (VDR) is a ligand-activated transcription factor that mediates estrogen and vitamin D actions in target ...common polymorphisms of the ER- αgene and VDR ... See full document

... Estrogens, vitamin D3, and growth hormone promote OPG synthe- sis in vitro ...among postmenopausal women using HT, with no differ- ences by HT type ... See full document

... with cancer within the boundaries of Sweden are reported to the Swedish Cancer Registry, which is regarded as a highly validated source of informa- tion ...on breast cancer diag- ...present ... See full document

... that breast cancers arise from various genetically distinct causal mechanisms, in other words that genetic heterogeneity is present, which acts to blur the gene–disease associations under ...inappropriate ... See full document

... and breast cancer, and was tested as such by introducing it into the logistic regression ...and case/control status assume multiplicative penetrance; that is, the OR comparing two haplotype ... See full document

... and breast cancer risk among postmenopausal ...Natl Cancer Inst 2004, ...Grobbee D, Boeing H, Lahmann PH, Nagel G, Chang-Claude J, Clavel-Chapelon F, Fournier A, Thiébaut A, ... See full document