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On the relative relevance of subject-specific geometries and degeneration-specific mechanical properties for the study of cell death in human intervertebral disk models.

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Academic year: 2019

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Table 1 | Specimen information.
Table 2 | Range of values (high and low levels) for the parameters analyzed with the DOE sensitivity, and values used as components for theinitial vector of parameters of the downhill simplex Python algorithm.
Table 3 | No damage: optimized values as a function of thedegeneration grades of the L3-L4 disks (seeTable 1 and Figure 1 forspecimen details) obtained through the minimization of the objectivefunction (Eq
Figure 7 shows the viability profiles predicted by the diffusionchamber model in comparison to the related experimental data(Horner and Urban, 2001), for the two cell density levels relevantto the IVD, and at the specific time relevant to the present study(3
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