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Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine

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Figure

FIG 1 Increased functional responsiveness of monocytes/macrophages and mDC. (A and B) Frequencies of IL-12- or TNF-CD69and mDC, respectively, in PBMC from naive controls and A�-producing monocytes/macrophagesMtb-vaccinated infant macaques at 16 to 18 weeks
FIG 2 CD4� T cell activation in tissues at 16 to 18 weeks after AMtb vaccination. Percentages of CCR5-, Ki67-, PD-1-, and CD69-positive CD4� T cells weremeasured by flow cytometric analysis in PBMC, retropharyngeal lymph nodes, and the colon at 16 to 18 wee
FIG 3 SIV challenge study outline. The figure shows the times of immunization (indicated by black arrows), the time of oralSIV exposures (red arrows), and lists the vaccine regimens for each of the groups
FIG 4 Vaccine-induced activation of myeloid cells at the time of SIV challenge. (A) Frequencies of IL-12- and TNF-a ratio of the level at week 9 (start of SIV challenge) divided by the level at week 0 (time of immunization)
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