Microencapsulation Nsu 2.ppt

Dr. Mohammad Shariare

Dr. Mohammad Shariare

Microencapsulation

Microencapsulation

Morphology of Microcapsules:

 The morphology of microcapsules depends mainly on

the core material and the deposition process of the shell.

1) Mononuclear (core-shell) microcapsules contain the shell around the core.

2) Polynuclear capsules have many cores enclosed within the shell.

3) Matrix encapsulation in which the core material is distributed homogeneously into the shell material.

Microencapsulation Techniques

I. Physico-Chemical Processes:

1) Coacervation:

- Two methods for coacervation are

available, namely simple and complex

processes.

-In simple coacervation, a desolvation

agent is added for phase separation.

Complex Coacervation

 Complex coacervation:

1) First the core material (usually an oil) is dispersed into a polymer solution (e.g., a cationic aqueous polymer, gelatin).

2) The second polymer (anionic, water soluble, gum arabic) solution is then added to the prepared dispersion.

3) Deposition of the shell material onto the core particles occurs when the two polymers form a complex.

Complex Coacervation



5)

Finally,

the

prepared

microcapsules are stabilized

by

crosslinking

(with

formaldehyde), desolvation or

thermal treatment.

Microencapsulation Techniques

3) Solvent Evaporation:

- It is the most extensively used method of microencapsulation.

1-Prepare an aqueous solution of the drug (may contain a viscosity building or stabilizing agent)

2- Then added to an organic phase consisting of the polymer solution in solvents like dichloromethane or chloroform with vigorous stirring to form the primary water in oil emulsion. 3- This emulsion is then added to a large volume of water

containing an emulsifier like PVA or PVP to form the multiple emulsion (w/o/w).

4- The double emulsion is then subjected to stirring until most of the organic solvent evaporates, leaving solid microspheres.

Microencapsulation Techniques

4) Polymer Encapsulation by Rapid

Expansion of Supercritical Fluids:

- Supercritical fluids are highly

compressed gasses that possess several

properties of both liquids and gases.

- The most widely used being supercritical

CO

and nitrous oxide (N

O).

- A small change in temperature or

Microencapsulation by rapid expansion

of supercritical solutions

Steps:

1-Supercritical fluid containing the active ingredient and the shell material are maintained at high pressure and then released at atmospheric pressure through a small nozzle. 2-The sudden drop in pressure causes desolvation of the

shell material, which is then deposited around the active ingredient (core) and forms a coating layer.

-Different core materials such as pesticides, pigments, vitamins, flavors, and dyes are encapsulated using this method.

-A wide variety of shell materials e.g. paraffin wax and polyethylene glycol are used for encapsulating core substances.

Microencapsulation Techniques

5) Hydrogel microspheres:

1- Microspheres made of gel-type polymers, such as

alginate, are produced by dissolving the polymer in an aqueous solution

2-Then, suspending the active ingredient in the mixture 3- Extruding through a precision device, producing micro

droplets

4- Then fall into a hardening bath that is slowly stirred. The hardening bath usually contain calcium chloride solution.

 The particle size of microspheres can be controlled by:

Microencapsulation Techniques

II

Physical Processes:

1) Spray-Drying & spray-congealing :

- Microencapsulation by spray-drying is a low-cost

commercial process which is mostly used for the

encapsulation of fragrances, oils and flavors.

Steps:

1- Core particles are dispersed in a polymer

solution and sprayed into a hot chamber.

2- The shell material solidifies onto the core

particles as the solvent evaporates.

Microencapsulation Techniques



Spray-congealing:

- This technique can be

accomplished with spray drying

equipment when the protective

coating is applied as a melt.

1- the core material is dispersed in

a coating material melt.

2- Coating solidification (and

microencapsulation) is

accomplished by spraying the hot

mixture into a cool air stream.

- e.g. microencapsulation of

Microencapsulation Techniques

2) Fluidized-Bed Technology:

- Different types of fluid-bed coaters include top

spray, bottom spray, and tangential spray.

- used for encapsulating solid or liquids absorbed

into porous particles.



Steps:

1-Solid particles to be encapsulated are

suspended on a jet of air and then covered by

a spray of liquid coating material.

2- The rapid evaporation of the solvent helps in

the formation of an outer layer on the particles.

3- This process is continued until the desired

Microencapsulation Techniques

Schematics of a fluidbed coater

-(a) Top spray;

Microencapsulation Techniques

3) Pan coating:

1- Solid particles are mixed with a dry

coating material.

2- The temperature is raised so that the

coating material melts and encloses the

core particles, and then is solidified by

cooling.

Microencapsulation Techniques

4) Co-Extrusion:

1- A dual fluid stream of liquid core and shell

materials is pumped through concentric

tubes and forms droplets under the influence

of vibration.

2-The shell is then hardened by chemical

cross linkings, cooling, or solvent

evaporation.

Microencapsulation Techniques

5) Spinning Disk:



Steps:

1- Suspensions of core particles in liquid shell

material are poured into a rotating disc.

2- Due to the spinning action of the disc, the core

particles become coated with the shell material.

3- The coated particles are then cast from the

edge of the disc by centrifugal force.

4- After that the shell material is solidified by

external means (usually cooling).