1h-Indole-2
Structure–activity study of N ((trans) 4 (2 (7 cyano 3,4 dihydroisoquinolin 2(1H) yl)ethyl)cyclohexyl) 1H indole 2 carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor
... particular interest, the 1,5-pentylene analogue (18c) displays competitive antagonism, whereas analogues containing the 1,3-propylene (18a), 1,4-butylene (18b) and 1,6-hexylene (18d) spacers display negative allosteric ...
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Synthesis and Characterization of Schiff Base Metal Complexes Derived from Cefotaxime with 1H indole 2,3 dione (Isatin) and 4 N,N dimethyl aminobenzaldehyde
... (sodium(6R,7R)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)- 2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylate) is a third generation ce- phalosporin ...
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3 Bromomethyl 1 phenylsulfonyl 1H indole 2 carbonitrile
... N—Csp 2 bond lengths N1—C2 and N1—C5 (Table 1) are longer than the mean value of ...planar indole ring system is influenced by the intramolecular C—H O inter- action involving sulfonyl atom O1 (Table ...the ...
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Ethyl 1,3 dimethyl 1H indole 2 carboxylate
... of 2-carbethoxy-3-methyl indole (0.5 mmol) in THF (2 ml) was added and stirred for 30 minutes at room ...the indole was consumed (monitored by TLC), the reaction mixture was quenched with cold ...
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3 Phenylsulfanyl 1 phenylsulfonyl 1H indole 2 carbaldehyde
... The bond lengths do not show unusual values. Atom N1 is not planar but pyramidal. Slight pyramidalization is also observed in related indoles (Yokum & Fronczek, 1997; Beddoes et al., 1986; Sethu Sankar et al., 2002). ...
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3 Chloro 1 phenylsulfonyl 1H indole 2 carbaldehyde
... The bond lengths and angles in (I) (Table 1) show normal values (Govindasamy et al., 1998). The angles O1—S1—O2 and N1—S1—C10 confirm the distorted tetrahedral geometry around atom S1, which may be attributed to the ...
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Aquabis(2,2′ bipyridine κ2N,N′)(1H indole 2 carboxylato κO)nickel(II) 1H indole 2 carboxylate dihydrate
... Data collection: SMART Bruker, 1998; cell refinement: SAINT Bruker, 1998; data reduction: SAINT; programs used to solve structure: SHELXS97 Sheldrick, 2008; programs used to refine struc[r] ...
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Dimethyl 3,3′ (phenylmethylene)bis(1H indole 2 carboxylate)
... C10 0.051 (2) 0.041 (2) 0.0364 (18) 0.0078 (17) 0.0204 (17) −0.0025 (16) C11 0.047 (2) 0.054 (2) 0.058 (2) 0.0163 (18) 0.0154 (19) 0.0062 (19) C12 0.0355 (17) 0.0329 (17) 0.0352 (17) ...
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3 Methyl 1 tosyl 1H indole 2 carbaldehyde
... form an almost centrosymmetric non-bonded dimer, in which the molecules are linked by pairs of C—H interactions. The crystal structure displays a three-dimensional network of C—H O interactions. A – interaction occurs ...
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Diethyl 3,3′ (phenylmethylene)bis(1H indole 2 carboxylate)
... Ethyl indole-2-carboxylate (18.9 g, 100 mmol) was dissolved in 200 ml ethanol; commercially available benzaldehyde (5.3 g, 50 mmol) was added and the mixture was heated to reflux temperature. Concentrated ...
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MICROWAVE ASSISTED SYNTHESIS OF INDOLE BASED 4 DIMETHYLAMINO PHENYL N METHYL/PHENYL PYRAZOLIDINE PYRAZOLE DERIVATIVES AND STUDY OF THEIR ANTIINFLAMMATORY ACTIVITY
... Chalcones (3a-b) were treated with 1H-indole-2-carbhydrazide (7a-e) to get target compounds (8a-j). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR ...
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Anti-Toxoplasma Activity of 2-(Naphthalene-2-γlthiol)-1H Indole.
... mmol) there was added 5 ml of trifluoroacetic acid (TFA). The mixture was refluxed for 1 h. On completion of the reaction, monitored by TLC, the TFA was evaporated off and the resi- due was diluted with ethyl acetate and ...
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3 Cyclohexylsulfanyl 2 (4 methylphenyl) 5,7 dinitro 1H indole
... A solution of 2-(cyclohexylsulfanyl)-1-(4-methylphenyl)-1-ethanone- N-(2,4-dinitrophenyl)hydrazone (0.001 mol) in di- methylforamide (5 ml) was allowed to cool in an ice bath with stirring. To this stirred ...
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5 Bromo 1H indole 3 carbaldehyde 2 nitrophenylhydrazone hemihydrate
... C1 0.0374 (12) 0.0464 (13) 0.0336 (11) −0.0023 (10) 0.0067 (9) 0.0008 (10) C2 0.0519 (16) 0.0702 (17) 0.0374 (13) 0.0077 (13) 0.0005 (11) 0.0076 (13) C3 0.0621 (19) 0.102 (2) 0.0326 (13) 0.0061 (17) 0.0008 (12) ...
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2 (2,5 Dimethylbenzyl) 3 phenylsulfanyl 1 phenylsulfonyl 1H indole
... C22 0.0486 (10) 0.0396 (9) 0.0505 (12) 0.0040 (7) −0.0051 (8) 0.0009 (8) C23 0.0659 (14) 0.0673 (14) 0.0564 (15) 0.0086 (11) −0.0128 (11) 0.0051 (11) C24 0.0789 (16) 0.0806 (16) 0.0496 (15) 0.0104 (13) 0.0172 (12) ...
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2 (2 Acetamido 5 methylbenzoyl) 1H indole
... Many idole derivatives, both natural and synthetic, show important biological activities such as antibacterial, antifungal (Wang & Ng, 2002; Singh et al., 2000; Tsotinis et al., 1997; Quetin-Leclercq et al., 1995), ...
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3 (4 Chlorophenyldiazenyl) 1 methyl 2 phenyl 1H indole
... Azo derivatives are used extensively in analytical chemistry and in the dyestuff industry as metallochromic and acid–base indicators (Rau, 1990; Zollinger, 1987). They are also used in the fields of nonlinear optics and ...
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1H Indole 3 carbaldehyde
... Data collection: APEX2 Bruker, 2004; cell refinement: APEX2 and SAINT Bruker, 2004; data reduction: SAINT and XPREP Bruker, 2004; programs used to solve structure: SHELXS97 Sheldrick, 20[r] ...
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1 Ethyl 2 phenyl 3 [2 (trimethylsilyl)ethynyl] 1H indole
... C10 0.0253 (7) 0.0314 (8) 0.0133 (7) 0.0077 (6) 0.0044 (6) −0.0040 (6) C11 0.0327 (8) 0.0436 (10) 0.0181 (8) 0.0098 (7) 0.0114 (6) 0.0030 (7) C12 0.0172 (6) 0.0197 (6) 0.0164 (6) 0.0002 (5) 0.0045 (5) −0.0045 (5) C13 ...
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2 [2 (5 Ethoxy 4 methoxy 2 nitrophenyl)vinyl] 1H indole
... 1-(Indol-2-yl)-2-(6-nitroveratryl)ethene (0.68 g, 2 mmol) and sodium ethoxide (0.24 g, 5 mmol) were added to dry THF (40 ml) and re¯uxed for 6 h. The solution was cooled and poured over crushed ice. ...
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