Actin binding domain
Molecular analysis of insertion/deletion mutations in protein 4 1 in elliptocytosis I Biochemical identification of rearrangements in the spectrin/actin binding domain and functional characterizations
... Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia ...
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The C Terminus of Rotavirus VP4 Protein Contains an Actin Binding Domain Which Requires Cooperation with the Coiled-Coil Domain for Actin Remodeling
... fusion domain which allows virus entry (11), other VP4 molecules to form oligomers (12), and peroxisomes ...apical actin cytoskeleton and induces its remodeling, leading to a disorganization of the brush ...
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Functional correction of dystrophin actin binding domain mutations by genome editing
... Dystrophin is a large intracellular protein that stabilizes muscle membranes against forces associated with contraction and stretch by providing a mechanical link between the intracellular actin cytoskele- ton and ...
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Actin Binding Domains Direct Actin-Binding Proteins to Different Cytoskeletal Locations
... a binding site on F-actin ...these actin-binding proteins with F-actin in living cells, we have made green fluorescent protein (GFP) probes consisting of each full length protein and ...
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Regulation of myotube formation by the actin-binding factor drebrin
... an actin-depolymerizing factor II/cofi- lin-like domain, an actin-binding domain and two Homer-binding domains [27], and it remodels actin to facilitate the maturation of ...
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Molecular analysis of insertion/deletion mutations in protein 4 1 in elliptocytosis II Determination of molecular genetic origins of rearrangements
... Protein 4.1 is an approximately 80-kD structural protein in the membrane skeleton which underlies and supports the erythrocyte plasma membrane. The preceding companion paper presents a biochemical study of two abnormal ...
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Novel Protein kinase C θ: Coronin 1A complex in T lymphocytes
... the actin-binding domain, nega- tively interferes with PKCθ-dependent IL-2 transactivation in Jurkat T cells (Figure ...the actin- binding function of Coro1A is not necessary for ...
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Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation
... purified actin binding domain of ACTN2 by circular dichroism and X-ray crystallography, and show small but distinct changes for both ...F- actin binding affinity, although the ...
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Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells
... ABD1: actin-binding domain 1; ACTA2: actin, alpha 2, smooth muscle, aorta; ACTC1: actin, alpha, cardiac muscle 1; BLAT: BLAST-like alignment tool; BMD: Becker muscular dystrophy; BMP4: ...
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Spectrin and phospholipids — the current picture of their fascinating interplay
... called actin-binding domain 2 (ABD2, as distinct from ABD1 which consists of two N-terminal CH domains) of dystrophin, in particular repeats 12 and 13 ...this domain plays a crucial role in ...
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Cell Polarity and Hyphal Morphogenesis Are Controlled by Multiple Rho-Protein Modules in the Filamentous Ascomycete Ashbya gossypii
... GTP binding and hydrolysis [amino acids (aa) 5–20, 53–62, and 154–160 of ScCdc42p], effector protein interaction (aa 26–50 of ScCdc42p), and the isoprenylation consen- sus motif at the very C-terminal part of ...
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Role of Actin-Bundling Protein Sac6 in Growth of Cryptococcus neoformans at Low Oxygen Concentration
... The importance of exposure to oxygen-limited environments during fungal pathogenesis has gained appreciation in the past few years (for a review, see reference 18). Recently, several studies have begun to unravel the ...
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A Role for GEA1 and GEA2 in the Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae
... and actin cytoskeleton in gea2⌬, gea1-4 gea2⌬, and gea1-6 gea2⌬ ...(C) Actin cytoskeleton in gea2⌬, gea1-4 gea2⌬, and gea1-6 gea2⌬ ...hr. Actin distribution was visualized with FITC- or Alexa- ...
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De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures
... Next-generation sequencing has been invaluable in the elucidation of the genetic etiology of many subtypes of intellectual disability in recent years. Here, using exome sequencing and whole-genome sequencing, we ...
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Thymosin β as an Actin-binding Protein with a Variety of Functions
... monomeric actin, which affects the dynamics of the cytoskeleton rearrangement, and therefore the mobility of cells, the capacity of differentiation, cell division, ...
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F-BAR family proteins, emerging regulators for cell membrane dynamic changes—from structure to human diseases
... SH3 domain. The SH3 domain is an evolutionarily con- served protein-protein interaction domain of 50–60 amino ...F-BAR domain association with membrane phospho- lipids (Figure ...SH3 ...
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Integration of the Rac1- and actin-binding properties of Coronin-1C
... between binding sites caused us to examine the localization of coronin-1C, actin and Rac1 within the ...bundled actin stress fibers (2A), which is not typically where Rac1 would be expected to ...
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Structural and functional characterization of the divergent Entamoeba Src using Src inhibitor 1
... conserved domain structure that consists of the consecutive peptide binding domains SH3, SH2, tyrosine kinase (SH1) domains, and SH4 domain; the last one always myristoylated, thus allowing the ...
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Tolbert_unc_0153D_14293.pdf
... the binding of the Arp2/3 complex as prevention of phosphorylation using the Y1065F variant, loses its ability to bind to Arp2/3 ...the binding status of Arp2/3 is supported by the vinculin crystal ...
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The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix
... the actin hydrophobic cleft ...WH2 domain-containing ...with actin subdomain 3, as opposed to subdomain 1 for other WH2 domains, such as the WAVE2 WH2 domain ...for actin and Tarp, ...
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