Activator/repressor
An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger
... of repressor pro- ...GaaX repressor is predicted to be inactive as a repressor and thereby the GaaR transcription factor remains ...that repressor proteins lacking bound inducer could ...
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Transcription Factor YY1 Binds to the Murine Beta Interferon Promoter and Regulates Its Transcriptional Capacity with a Dual Activator/Repressor Role
... YY1 regulates virus-induced activation and transcriptional turn off of the IFN-  promoter. Protein YY1 has been shown to have bifunctional activator/repressor transcriptional proper- ties (19). As shown in ...
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Activator and Repressor Functions of the Mot3 Transcription Factor in the Osmostress Response of Saccharomyces cerevisiae
... a repressor/activator has been suggested earlier based on the abil- ity of Mot3 to activate gene expression from artificial reporter genes or by the reciprocal regulation of specific CWP genes in response ...
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Analysis of Activator and Repressor Functions Reveals the Requirements for Transcriptional Control by LuxR, the Master Regulator of Quorum Sensing in Vibrio harveyi
... a dual-function global transcriptional regulator. In many ways, our analysis suggests that LuxR is more similar to CRP than to TetR. CRP is an activator and repressor of transcription of ⬎ 200 genes ...
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CREB-2, a Cellular CRE-Dependent Transcription Repressor, Functions in Association with Tax as an Activator of the Human T-Cell Leukemia Virus Type 1 Promoter
... the full-length clone was later isolated and named TAXREB67 (49) or CREB-2 (21). Members of the ATF/CREB family are characterized by basic-leucine zipper (bZIP) C-terminal do- mains required for DNA recognition and ...
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Conversion of the LIN-1 ETS Protein of Caenorhabditis elegans from a SUMOylated Transcriptional Repressor to a Phosphorylated Transcriptional Activator
... tional repressor that inhibits vulval cell ...transcriptional activator in response to active ...transcriptional activator that promotes the 1 ° vulval cell ...
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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
... It has been suggested that a mutual repression between Gli3 and Hand2 in the early limb buds sets up a limb prepattern that determines the anteroposterior polarity of the limb (te Welscher et al., 2002a). This prepattern ...
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Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response
... mammalian repressor and activator protein (Rap1, also known as telomeric repeat-binding factor 2-interacting protein 1), is a component of the shelterin complex at the telomere and dependent on TRF2 for ...
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Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
... N-terminal repressor form (Gli3R), but Shh signaling counteracts this processing and high levels of Shh signaling can induce a weak Gli3 activator (Bai et ...transcriptional activator (Gli2A) by ...
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Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.
... paired-homeodomain repressor for a paired-homeodo- main activator, with resultant alteration in the expres- sion of key target genes, now prevents ...
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The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection.
... Multiple layers of Rep control. As mentioned earlier, given the life cycle of AAV, it would not be surprising to find that there are multiple layers of Rep control that behave differently in the presence and absence of ...
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The Switch from Fermentation to Respiration in Saccharomyces cerevisiae Is Regulated by the Ert1 Transcriptional Activator/Repressor
... These results suggested that ERT1 encodes a factor in- volved in the utilization of nonfermentable carbon sources. To test this hypothesis, ChIP-chip assays were then per- formed with cells grown in the presence of ...
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Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor
... (Ohto et al., 1999). Sequences in the SD/HD region target the complex to DNA and the Eya conserved N-terminal domain causes the complex to activate transcription (Pignoni et al., 1997; Xu et al., 1997; Kawakami et al., ...
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Truncation of the transcriptional repressor protein Cre1 in Trichoderma reesei Rut-C30 turns it into an activator
... Results: In this study, we deleted and constitutively expressed cre1‑96 in Rut‑C30. We found that the presence of Cre1‑96 in Rut‑C30 is crucial for its cellulolytic and xylanolytic performance under inducing conditions. ...
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Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
... ABSTRACT MtrA is a member of the AraC family of transcriptional regulators and has been shown to play an important role in enhancing transcription of the mtrCDE operon, which encodes a tripartite multidrug efflux pump, ...
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Meis2 competes with the Groucho co repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain hindbrain boundary organizer
... transcriptional activator or repressor depending on the cellular ...co- repressor protein Tle4 is sufficient to attenuate Otx2 transactivation activity and leads to effective repression of an ...
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Ftm is a novel basal body protein of cilia involved in Shh signalling
... The Hedgehog (Hh) family of secreted proteins plays an important role during embryonic development in regulating growth, patterning and morphogenesis of many tissues (Ingham and McMahon, 2001). In invertebrates, such as ...
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Multiple elements and auto-repression regulate Rox1, a repressor of hypoxic genes in Saccharomyces cerevisiae.
... Tupl-dependent repressor that repressed anaerobic ex- pression; Roxl itself that repressed its own expression; and an unidentified transcriptional activator, which is responsibl[r] ...
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Changes in students’ mental models from computational modeling of gene regulatory networks
... post models (Table 2). Two general structures, mRNA and operon, appeared in 5% and 13%, respectively, of pre models and increased significantly in presence (11% and 23%) in post models. The number of labeled rela- ...
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“Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma”
... an activator site and the other in a repressor site; this variant was not found reported [25, 26]; (b) the variant was unexpectedly found in PBL DNA from the index case’s mother, who transmitted it to two ...
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