Acute Leukemias
Emergence of heterogeneity in acute leukemias
... In acute leukemias, where genetic instability is rare, gener- ation of large numbers of mutated cells and selection of those which exactly fit the properties required to establish deep hierarchies is not a ...
19
Drugging the unfolded protein response in acute leukemias
... The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1 α , PERK, and ATF6 α . Studies described the UPR as a critical network ...
10
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.
... of acute leukemias and primary cancer cells, which may reveal information on the links between pluripotency and oncogenic transformation that would be instrumental for the development of new ...
17
A Study on the Occurrence and Subtyping of Acute Leukemias Based on Morphology and Cytochemistry.
... Despite the advent of modern ancillary techniques, morphologic examination and cytochemical staining of well-prepared air-dried peripheral blood smears and bone marrow smears are critical in the pathologic diagnosis and ...
72
Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias
... of acute leukemia ...derived acute leukemia cells to grow and disseminate in SCID mice by subcutaneous inoculation without condi- tioning treatment or administration of growth promoting ...
10
Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies
... childhood acute lymphoblastic leukemia (ALL) can be improved by including normal hematopoietic subpopulations ...and acute myeloid leukemia (AML) show any significant similarities to those present in an ...
8
Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma
... lymphoma is uncertain. The therapeutic potential of araC has been assessed in patients with AML, ALL, and T lymphoblastic lymphoma by measuring the conversion of araC to its active metabolite, the 5'-triphosphate of araC ...
12
A study on clinical, immunophenotypic pattern in pediatric acute leukemias in a teaching hospital
... A study from Adyar cancer institute showed that the completeness of treatment and the type of hospital emerged as one of the most important factor affecting the survival in paediatric cancers, especially acute ...
7
The role of hypoxia-inducible factors in leukemias
... cells. Acute leukemias are defined by proliferation of immature hematopoietic cells that fail to differentiate and accumulate in bone marrow and other organs, inhibiting the growth of normal hematopoietic ...
5
Cluster of Differentiation 45: An Adjunct to Flowcytometric Diagnosis of Leukemias
... diagnosis in these cases relied predominantly on morphologic and cytochemical features, but now, it is supplemented with immunophenotypic, cytogenetic, and molecular data to define clinically relevant diagnostic ...
5
Classifying types of disseminated intravascular coagulation: clinical and animal models
... in acute leukemias (especially acute pro- myelocytic leukemia (APL)), aortic aneurysm, abruptio placentae, and metastatic prostate cancer; namely, DIC in which severe bleeding symptoms are common due ...
7
MLL rearrangements in pediatric acute lymphoblastic and myeloblastic leukemias: MLL specific and lineage specific signatures
... The presence of MLL rearrangements in acute leukemias results in a complex number of biological modifications that still remain largely unexplained. Armstrong et al. [9] proposed MLL rearrangement positive ...
12
PATTERN OF BASIC HEMATOLOGICAL PARAMETERS IN ACUTE AND CHRONIC LEUKEMIAS
... TLC, low Hb and low platelet count is a diagnostic clue that should prompt a physician to keep Acute leukemia in differential diagnoses and it should not be missed. Many cases of infections may show anemia and ...
5
Streszczenie
... including acute leukemias. Its expression in the majority of human acute leukemias but not in normal mononuclear blood cells and normal CD34 + ...
7
An approach in the assessment of hematolymphoid neoplasms
... distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia (ALL) of either T or B lineages based on the distinct immunophenotypic profiles of the leukemic ...in acute ...
15
CD 117: Lineage assigning marker in acute myeloid leukemias
... firmly Acute Myeloid Leukemia and no further work-up is ...of Acute Leukemias is dependent on cytogenetics and molecular studies but in a setup where these facilities are not available, flow ...
7
Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
... 18. Shabani M, Asgarian Omran H, Farsangi MH, Vossough P, Sharifian RA, Toughe GR, et al. Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid ...
6
Cytogenetics of Leukemias: Identifying Genetic Abnormalities with Clinical and Prognostic Significance
... Unlike ALL, Acute Myeloid Leukemia (AML) is most common in the elderly population, with an incidence of approximately 3.4 per 100,000 per year and a median age of 70 years at diagnosis [37]. Furthermore, in ...
16
The cell cycle checkpoint inhibitors in the treatment of leukemias
... Nowadays, the amount of pre-clinical data has con- firmed the efficacy of different cell cycle checkpoint in- hibitors against different kinds of hematologic as well as solid tumors, as single agent, or in combination ...
14
<p>Myeloid Leukemias: A Glance at Middle Eastern Centers</p>
... Myeloid leukemias (MLs) are a heterogeneous group of disorders in which a leukemogenic event disrupts normal hematopoietic stem cell differentiation and enhances its ...
9