Alternative polyadenylation (APA)
Alternative polyadenylation analysis in animals and plants: newly developed strategies for profiling, processing and validation
... validate APA sites and their expression ...H alternative polyadenylation assay) [40] and 3’RACE-seq (3’ rapid amplification of cDNA end sequencing) [41] that were designed to directly validate ...
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Alternative polyadenylation factors link cell cycle to migration
... of APA factors, as occurs in response to antiproliferative signals via E2F transcription factors [21], reduces the capacity of fibroblasts to migrate into a de- nuded area, represents another mechanism linking ...
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Accurate Profiling of Gene Expression and Alternative Polyadenylation with Whole Transcriptome Termini Site Sequencing (WTTS-Seq)
... and alternative polyadenylation ...detect APA diversity and dynamics, its combination with WTTS-seq is necessary to validate transcriptome-wide ...
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Genome-wide profiling reveals cancer-related genes with switched alternative polyadenylation sites in colorectal cancer
... Background: Alternative polyadenylation (APA) is an important post-transcriptional regulation in eukaryotic ...the APA of CRC, the normal and carcinoma samples used for genome-wide profiling ...
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Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues
... through alternative polyadenylation (APA) ...use APA and harbor miRNA targets in their 39UTRs, which are commonly lost in a tissue-specific manner, suggesting widespread usage of ...
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Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation
... from alternative cleavage and polyadenylation ...and polyadenylation is required for maturation of most mRNA ...contain alternative polyadenylation sites [17]; AAUAAA is the canonical ...
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NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation
... as alternative polyadenylation (APA) [5]. APA is now recognized as an important post-transcriptional regulator, which can affect gene expression in multiple ...from APA [6]. Using ...
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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
... and polyadenylation gives rise to transcripts with var- ied 3′-UTR lengths and in some cases an altered reading frame, a process known as alternative polyadenylation (APA) (6, ...in APA ...
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Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
... the alternative polyadenylation outcome depends on the intrinsic affinity of the PAS with the polyadenylation machinery and the abundance of the core 3’ processing ...the alternative ...
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Alternative Polyadenylation of Human Bocavirus at Its 3′ End Is Regulated by Multiple Elements and Affects Capsid Expression
... regulate alternative polyadenylation at (pA)d and ...affect polyadenylation at (pA)d2 in the context of an infectious ...reduced polyadenylation at both (pA)d and (pA)d2, as determined by ...
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Differential genome-wide profiling of alternative polyadenylation sites in nasopharyngeal carcinoma by high-throughput sequencing
... APA, which leads to alterations in 3’UTR length and content of genes, shows dynamic characteristics in a var- iety of tumors. A previous analysis of 27 cancer cell lines derived from sarcomas and breast, lung and ...
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QAPA: a new method for the systematic analysis of alternative polyadenylation from RNA seq data
... of APA from whole transcript RNA-seq data QAPA quantifies APA levels using RNA-seq reads that uniquely map to 3′ UTR sequences demarcated by anno- tated poly(A) sites in last ...of alternative 3′ UTR ...
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Developmental dynamics of gene expression and alternative polyadenylation in the Caenorhabditis elegans germline
... The length of 3′UTRs was generally much shorter in males, as also observed in D. melanogaster [37]. This suggests that the spermatogenic program may rely more heavily on transcriptional regulation, though some key events ...
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Landscape and evolution of tissue specific alternative polyadenylation across Drosophila species
... of APA isoforms in eukaryotes is the specific accumulation of isoforms in a tissue- and length-specific ...of APA to specifically modulate the maternal transcrip- tome during this developmental transition ...
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Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control
... of alternative polyadenylation (SAAP) method to identify significantly regulated APA events, as previously described ...regulated APA events. Global analysis of alterna- tive ...
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Minute Virus of Canines NP1 Protein Governs the Expression of a Subset of Essential Nonstructural Proteins via Its Role in RNA Processing
... in alternative polyadenylation and alternative splicing of the single MVC pre- ...by alternative multiply spliced ...internal polyadenylation site, (pA)p, and that generation of these ...
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Alternative Transcription Initiation Sites and Polyadenylation Sites Are Recruited During Mu Suppression at the rf2a Locus of Maize
... suppression, alternative transcription initiation sites flanking the Mu1 transposon yield functional ...as alternative polyadenylation sites such that the suppressed rf 2a- m8110 allele yields ...
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Minute Virus of Canines NP1 Protein Interacts with the Cellular Factor CPSF6 To Regulate Viral Alternative RNA Processing
... regulating alternative polyadenyl- ation via interaction with polyadenylation factors (32, 47, 48), components of the U2 snRNP (49), SR proteins (SRSF3 and SRSF7), and the nuclear methylation reader YTHDC1 ...
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APA 6th[1]
... In this edition of the Publication Manual, we present updated journal article reporting standards, and these are also discussed in this chapter.. These reporting stan- dards relate to ma[r] ...
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APA citation basics
... When using APA format, follow the author-date method of in-text citation. This means that the author's last name and the year of publication for the source should appear in the text, for example, (Jones, 1998), ...
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