amino acid substitutions
Multiple amino acid substitutions involved in the adaption of three avian origin H7N9 influenza viruses in mice
... the amino acids changes revealed 10 amino acid substitutions located in PB2 (E627K), PB1 (W215R and D638G), PA (T97I), HA (H3 numbering: R220G, L226S, G279R and G493R) and NA (P3Q and R134I) ...
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Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice
... Several amino acid substitutions in- cluding PB2 (Q591K and D701N), polymerase acidic protein (PA) (I554V), HA (S227N), and NP (R351K) have been described in mouse adapted H5N2 AIVs that have ...
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Amino Acid Substitutions in the V Domain of Nectin-1 (HveC) That Impair Entry Activity for Herpes Simplex Virus Types 1 and 2 but Not for Pseudorabies Virus or Bovine Herpesvirus 1
... 21 amino acids from the C terminus of the 306-amino-acid soluble form of gD was shown to have even larger effects of a decreased dissociation constant (and thus an increased affinity for nectin-1) ...
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Effects of amino acid substitutions at the active site in Escherichia coli beta-galactosidase.
... This approach to protein engineering has been employed previously, using five of the naturally occurring amber suppres- sors (MILLER et al. T h e addition of seven [r] ...
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Harmful somatic amino acid substitutions affect key pathways in cancers
... In ALL, only 2 proteins (encoded by PHF6 and NOTCH1) were selected, therefore we included all genes contain- ing one or more variations leading to harmful AASs. GO enrichment analysis indicates that biological pro- ...
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<p>Molecular Investigations of Linezolid Resistance in Enterococci <em>OptrA</em> Variants from a Hospital in Shanghai</p>
... Through the method of broth microdilution, only two strains were detected with low linezolid resistant level (MIC=8 μg/mL). This conceded that optrA was not only present in linezolid-resistant enterococci. At the same ...
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Mechanism of Cell Culture Adaptation of an Enteric Calicivirus, the Porcine Sapovirus Cowden Strain
... 3 amino acid substitutions, which in- cluded V716I and H845R in the 3A-like protease (NS4) region and E296K in the P2 region of ...single amino acid substitution in the P2 region of VP1 ...
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Identification of a membrane fusion domain and an oligomerization domain in the baculovirus GP64 envelope fusion protein.
... mediate acid-triggered membrane fusion both in virions and when expressed alone in transfected ...hydrophobic amino acids exhibiting the highest local hydrophobicity in the ...nonconservative amino ...
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MICROBIOLOGICAL SCREENING OF IRISH AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY (APECED) PATIENTS REVEALS PERSISTENCE OF CANDIDA ALBICANS STRAINS, GRADUAL REDUCTION IN SUSCEPTIBILITY TO AZOLES AND INCIDENCES OF CLINICAL SIGNS OF ORAL CANDIDIASIS WITHOUT CULTURE EVIDENCE
... Amino acid substitutions identified in the ERG11 and TAC1 genes of isolates exhibiting reduced azole susceptibility that.. were not present in P4V2 are indicated.[r] ...
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Host and phi X 174 mutations affecting the morphogenesis or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate.
... The ogr(rep) mutations confer amino acid substitutions in the viral coat protein, a constituent of the prohead, and the viral A protein, a constituent of the prei[r] ...
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Nucleotide and Predicted Amino Acid Sequence Based Analysis of the Avian Metapneumovirus Type C Cell Attachment Glycoprotein Gene: Phylogenetic Analysis and Molecular Epidemiology of U S Pneumoviruses
... no amino acid substitutions in the predicted G proteins of aMPV/CO/C and aMPV/MN1a/C isolates, with 100% sequence ...several amino acid substi- tutions occurred in the predicted G ...
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The Region between Amino Acids 245 and 265 of the Bovine Leukemia Virus (BLV) Tax Protein Restricts Transactivation Not Only via the BLV Enhancer but Also via Other Retrovirus Enhancers
... between amino acids 240 and 265, namely, at codon 240 (S3T), at codon 247 (D3G), at codon 251 (T3A), at codon 258 (D3G), at codon 261 (H3R), at codon 261 (H3Y), and at codon 265 ...included amino acids 240 ...
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Chlorella Virus-Encoded Deoxyuridine Triphosphatases Exhibit Different Temperature Optima
... nine amino acids from the PBCV-1 enzyme, including two amino acid substitutions, Ser813Glu81 and Arg843Thr84, in the highly conserved mo- tif III of the protein ...these amino ...
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Systematic Study of the Genetic Response of a Variable Virus to the Introduction of Deleterious Mutations in a Functional Capsid Region
... second-site amino acid substitutions that, in some cases, were responsible for restoring the infectivity, thus acting as compensatory mutations ...second-site amino acid sub- stitutions ...
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Molecular characterization of influenza viruses collected from young children in Uberlandia, Brazil from 2001 to 2010
... and amino acid changes in these regions have been associated with annual epidemics in ...more amino acid substitutions located in two or more antigenic sites in this domain ...These ...
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Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication.
... conservative amino acid substitutions of 17 residues within the amino terminus of BPV type 1 E2 that are invariant among papillomavirus ...single amino acid substitu- tions that ...
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Loss and Gain of Elicitor Function of Soybean Mosaic Virus G7 Provoking Rsv1-Mediated Lethal Systemic Hypersensitive Response Maps to P3
... both amino acids have small hydro- phobic side chains, and hence, the impact on tertiary structure of P3 is predicted to be ...the amino acid substitution resulted in induction of a mild SHR ...the ...
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Rapid Screening of Fluoroquinolone Resistance Determinants in Streptococcus pneumoniae by PCR Restriction Fragment Length Polymorphism and Single Strand Conformational Polymorphism
... no amino acid ...three amino acid substitutions, as shown in SSCP patterns 3 to ...These amino acid substitutions included Ser-79-Phe, Asp-83-Asn/Tyr, Glu-96-Asp, ...
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Molecular Characterization of Extraintestinal Escherichia coli Isolates in Japan: Relationship between Sequence Types and Mutation Patterns of Quinolone Resistance Determining Regions Analyzed by Pyrosequencing
... Infection from fluoroquinolone-resistant Enterobacteriaceae is an increasing health problem worldwide. In the present study, we developed a pyrosequencing-based high-throughput method for analyzing the nucleotide ...
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Unique Pattern of Convergent Envelope Evolution in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques: Association with CD4-Independent Usage of CCR5
... had substitutions within the GDPE motif, three had the G386R substitution, one had D388N, and two contained both ...had substitutions downstream of V1 that resulted in the loss of an N-linked glycosylation ...
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