amino-terminal domain
Assessment of the PrPc Amino-Terminal Domain in Prion Species Barriers
... amyloid state by CWD prions and that the NTD facilitates this conversion. As there is little evidence for the susceptibility of humans to CWD, the biologic significance of our observation remains to be determined. ...
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Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.
... autonomous amino-terminal domain in the form of tiny T antigen raises the question as to whether it has a separate function in productive infection and transfor- mation of ...DnaJ domain might ...
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Ty3 Capsid Mutations Reveal Early and Late Functions of the Amino-Terminal Domain
... in amino-terminal and carboxyl-terminal ...the amino-terminal domain reduced the formation of fluorescent Ty3 protein ...carboxyl-terminal domain shifted assembly ...
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Requirement for the Amino-Terminal Domain of Sindbis Virus nsP4 during Virus Infection
... nsP4 amino-terminal ...150-residue amino-terminal region fails to demonstrate similarity to those of known RdRps ...The amino-terminal region also contains a span of more than 60 ...
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The amino terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV 1 infection
... anti– amino-terminal antibodies, MCP-1R01 and MCP-1R02, but not MCP-1R05, behave like MCP-1 and block HIV-1 virus in- ...The amino-terminal residues of the CCR2B receptor appear to be ...
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Genetic Mapping of the Amino-Terminal Domain of Bacteriophage T4 DNA Polymerase
... determine the locations of the ts lesions within the T4 DNA segments defined by cloned T4 DNA restriction fragments. About half of the ts mutants isolated in the nitrosoguanidin[r] ...
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Molecular characterisation of the HMG CoA reductase gene from Neotyphodium Lolii : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Genetics at Massey University, Palmerston North, New Zealand
... From comparison to other Hmg proteins the catalytic domain has been shown to be highly conserved while the amino-terminal domain, containing transrnembrane regions is divergent with very[r] ...
150
Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
... the domain(s) of Vpr involved in virion incorporation, nuclear localization, dif- ferentiation, and cell cycle arrest functions, we constructed a series of mutated versions of Vpr molecules ...acidic domain ...
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Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model
... conserved amino- terminal ...boxy-terminal domain of E3L is required for replication in HeLa cells and is also required for replication in the presence of IFN (6, 7, 38, ...the amino ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... carboxyl-terminal domain of the HNF3 polypeptide was not required for the activation of transcription from the nucleo- capsid or large surface antigen ...the amino-terminal transcrip- tional ...
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Tyrosine 112 of Latent Membrane Protein 2A Is Essential for Protein Tyrosine Kinase Loading and Regulation of Epstein-Barr Virus Latency
... LMP2A amino-terminal domain that is essential for the LMP2A-mediated block on BCR signal transduction contains eight tyrosine ...YEEA amino acid motif at LMP2A tyrosine 112 ...
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Peroxisome membrane proteins: Multiple trafficking routes and multiple functions?
... PMPs. Domain mapping approaches have provided evidence for three distinct functional regions in human Pex19: an amino-terminal domain that binds Pex3p and which is essential for docking at the ...
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Suppression of retroviral MA deletions by the amino-terminal membrane-binding domain of p60src.
... Indeed, it has been found recently that small, internal deletions in the MA domain of the myristylated Gag protein of Mason-Pfizer monkey virus completely block particle formation, even [r] ...
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An overview of the structures of protein DNA complexes
... The amino-termi- nal domain (about 120 residues) contains the catalytic center and the dimerization ...carboxy-terminal domain (approximately 40 residues) is a three-helix bundle with the ...
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Characterization of an Amino-Terminal Dimerization Domain from Retroviral Restriction Factor Fv1
... To identify the N-terminal sequence of these smaller frag- ments and confirm the correct sequence of the full-length protein, each band was analyzed by automated Edman degra- dation (Fig. 1b and c). No sequence ...
11
Characterization of a Toxoplasma gondii calcium calmodulin dependent protein kinase homolog
... The motility of T. gondii tachyzoites is activated by an increase in the cytosolic Ca 2+ concentration [16], which occurs as the parasites egress from the host cells [17, 18]. This increase in Ca 2+ concentration causes ...
10
Substitution of the carboxyl terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice
... the amino acid se- quence of the carboxyl-terminal domain of human apo AI, apart from its ability to determine lipoprotein association, is not critical for the efficiency of HDL to act as cholesterol ...
8
Mapping of Sequences in Pseudorabies Virus pUL34 That Are Required for Formation and Function of the Nuclear Egress Complex
... 15 amino acids (27– ...100 amino acids, retaining only amino acids 1 to 161 of the 262 amino acids of PrV pUL34, resulted in a nonfunctional protein although it was still able to recruit ...
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Degrons at the C Terminus of the Pathogenic but Not the Nonpathogenic Hantavirus G1 Tail Direct Proteasomal Degradation
... residues (C1 to C9 from the C terminus) (Fig. 6). In order to identify critical residues that differentiate the stability proper- ties of NY-1V and PHV G1 tails, we mutated C1 to C9 of the NY-1V G1 tail to homologous PHV ...
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Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants.
... As previously observed in the transfected rat-2 cells, mutations in the amino-terminal src-specific domain amino acids 8 to 87 did not affect the transforming capacity of v-src, while mo[r] ...
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