Anti-Tumor Immunity
Possible stimulation of anti-tumor immunity using repeated cold stress: a hypothesis
... enhance anti-tumor immunity and improve cancer survival rate in a mouse (non-lymphoid) tumor ...of tumor immunology are devoted to finding ways to elicit a tumor-specific CTL ...
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CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity
... with no effect on the primary tumor size (Figure 5A, right panel). Further, CXCR3 was expressed in most of the host immune cells including Gr-1 + CD11b + immature myeloid cells, F4/80 macrophages, B cells, CD4, ...
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Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma
... on anti-tumor immunity in a spontaneous murine model of ...primary tumor develops in the ocular ...primary tumor cells disseminate early, remain dormant for several weeks [33], but ...
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Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes
... potent anti-tumor immunity through triggering T ...weak anti-tumor immunity, only inhibiting the growth of rechallenged ...improved anti-tumor immunity in ...
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Augmenting Anti-Tumor Immunity by Targeting Macrophage Cox-2 in Breast Cancer
... for tumor progression towards ...the tumor with the goal of tumor cell destruction, can be hijacked by tumor cells to instead suppress anti-tumor immunity and enhance ...
175
Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2
... Polycomb group proteins regulate chromatin structure and have an important regulatory role on gene expression in various cell types. Two polycomb group complexes (Polycomb repressive complex 1 (PRC1) and 2 (PRC2)) have ...
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Cell death in photodynamic therapy: From oxidative stress to anti tumor immunity
... induce anti- tumor immunity upon treatment with ...an anti-cancer immune response as their DCs are incapable to interact with anthracycline-killed cancer cells and hence, no cross-presentation ...
41
TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy
... “cold tumor”, characterized by the lack of antigen presentation, immune response gen- eration, and/or tumor CTL infiltration ...“cold tumor” into “hot tumor” that are more susceptible to ...
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Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer
... cell anti-tumor ...of tumor-infiltrating DCs and MDSCs ...boost anti-cancer immunity by enhancing myeloid cell function in the tumor microenvironment [82 – ...
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Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis
... the anti-tumor activity not only by induction of T-cells by CD3-binding, but also by simultaneous activa- tion of accessory cells ...T-lymphocytes, tumor cells and accessory cells induces efficient ...
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Virus-stimulated neutrophils in the tumor microenvironment enhance T cell-mediated anti-tumor immunity
... suppressed tumor growth, but the combination of HVJ-E with poly I:C, but not with MPL, demonstrated a greater reduction in melanoma growth compared with either HVJ-E or poly I:C ...the anti-tumor ...
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<p>IL-37 induces anti-tumor immunity by indirectly promoting dendritic cell recruitment and activation in hepatocellular carcinoma</p>
... mouse anti- human IL-37 (1:1,000 dilution; Abcam, Cambridge, UK), mouse anti-human CD1a (1:100 dilution; Zhongshan Golden Bridge Biotech ...rabbit anti-mouse IL-37 (1:1,000 dilution; Tianjun, ...
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Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system
... immune-mediated tumor rejection by immune checkpoint blockade (ICB) ...irradiated tumor into a site for priming of tumor-specific T cells, that is, an in situ vaccine, and can induce responses in ...
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Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine
... In humans, the DRibbles vaccine was first evaluated as an autologous vaccine manufactured with tumor cells isolated from pleural effusions of patients with NSCLC. In this phase I clinical trial, autologous ...
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Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment
... harvested tumor masses, lung surface, and chest cavity were dissected then individually ...counted. Tumor weights were determined by pooling all nodules prior to tissue ...
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Reactivation of dormant anti-tumor immunity – a clinical perspective of therapeutic immune checkpoint modulation
... of tumor tissue. However, tumor biopsies are sometimes difficult or even impossible to obtain and, depending on the location of the tumor, may be associ- ated with relevant side effects such as an ...
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The Optimal Radiation Dose to Induce Robust Systemic Anti-Tumor Immunity
... Figure 2. Comparison of model simulated growth dynamics with experimental data. Solutions to the proposed model (Eqs. (3)-(10)) were obtained after performing data fitting (estimated parameters are presented in Table 1). ...
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Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy
... Generally speaking, apoptosis can overshadow necroptosis, implying that apoptotic death is the first choice in most settings and that necroptosis acts only as an alternative to ensure cell demise [242]. However, ...
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Immune status of pancreatic cancer patients receiving cryosurgery
... enhance anti- tumor immunity, the combined immunotropic therapy was performed in the following dosage and administration: Reamberin was administered at a dose 400 ml intravenously OD every day in the ...
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STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models
... activates anti-tumor immunity and induces regression of pancreatic tumors While dual treatment with the STING agonist and gemcita- bine evoked anti-tumor immune responses and provided a ...
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