anticoagulant drug
ABSTRACT: The excited-state lifetimes of the anticoagulant drug warfarin (W) in water
... the anticoagulant drug warfarin (W) in water and in the absence and presence of methyl-β-cyclodextrins (Me-β-CD) were recorded using time-resolved fluorescence ...
23
Development and Validation of Stability Indicating RP HPLC Method on Core Shell Column for Determination of Degradation and Process Related Impurities of Apixaban—An Anticoagulant Drug
... an anticoagulant drug chemically known as l-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-l-yl) phenyl]-4,5,6,7-tetrahydro-lH-pyrazolo[3,4-c]pyridine-3-carboxamide and sold under the brand name “Eliquis” to ...
12
Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin
... The interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin was studied by equilibrium dialysis. A 20-fold variation of buffer ionic strength (0.017-0.340) caused no ...
11
Stress study and estimation of a potent anticoagulant drug rivaroxaban by a validated HPLC method: Technology transfer to UPLC
... Alkaline degradation study was performed by heating the drug content in 20ml 0.1 N NaOH for 60 minutes at 80ºC. After heating equilibrate the solution at room temperature and the mixture was neutralized with 0.1 N ...
10
Predictors of new oral anticoagulant drug initiation as opposed to warfarin in elderly adults: a retrospective observational study in Southern Italy
... the drug ellux pump, P-glycoprotein (P-gp),drugs affecting the activity of P-gp, such as atorvastatin, clarithromycin, and diltiazem, can increase the risk of bleeding, thromboembolism, and further adverse ...
8
Practical synthetic approach to related substances of Rivaroxaban; an anticoagulant drug substance
... inhibitor drug developed by Bayer used for treatment and prevention of various thromboembolic diseases, in particular pulmonary embolism, deep venous thrombosis, myocardial infraction, angina pectoris, reocclusion ...
8
The Benefits of Using a Complete Probability Distribution when Decision Making: An Example in Anticoagulant Drug Therapy
... Mixture Density Networks MDN refer to a special type of artificial neural network in which the target is represented as a probability distribution, or, more specifically, a conditional p[r] ...
22
Rectus Sheath Hematoma
... In conclusion; RSH is a rarely seen event that should definitely be kept in mind during differential diagnosis of acute abdomen in old female patients. Although there was medical history of anticoagulant ...
8
Anticoagulant Activity of Methylated Coumarin Derivatives
... and anticoagulant drug are main inspiration of this ...single drug molecule with antihypertensive activity of propranolol and anticoagulant activity of warfarin ...
8
Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis
... and anticoagulant therapy to achieve increased antithrombotic efficacy carries a substantial risk of major bleeding with incomplete protection of thrombotic ...and anticoagulant drug activity at the ...
19
In Vitro Cardiac Risk Reduction Bioactive Substance from the Seedlings of Echinochloa frumentacea and Panicum sumantrance
... Drug replacement with appropriate remedies are required to eradicate existing problem in thrombosis. It rectified with partially purified thrombolytic enzyme from the seedling of Panicum sumatrance and Echinochola ...
6
Anticoagulant treatment at a specialized outpatient anticoagulant therapy unit, a descriptive study
... The most common target treatment range in this study was INR 2.1–3.0. After the completion of the study the tar- get range had been changed to 2.0–3.0 in most of these cases. In a study by Samsa et al, 45.0–66.8% of the ...
7
Activation of Protein C In Vivo
... the anticoagulant activity; (b) the anticoagulant activity can be partially purified from the plasma of dogs infused with thrombin by barium citrate adsorption; (c) the anticoagulant has ...
9
MOLECULAR MODELLING, 3D QSAR, AND DRUG DOCKING STUDIES ON THE ROLE OF NATURAL ANTICOAGULANT COMPOUNDS IN ANTITHROMBOTIC THERAPY
... only anticoagulant prescribed in the twentieth century, but it was found to have a variety of side effects including hypersensitivity, bleeding after halting therapy, nausea, vomiting, hives, and breathing trouble ...
12
Natural anticoagulant mechanisms
... Antithrombin neutralizes the activity of thrombin as well as other serine proteases of the intrinsic coagulation cascade by formation of a 1:1 stoichiometric complex between enzyme and i[r] ...
7
Glassberg_unc_0153D_17468.pdf
... oral anticoagulant comparator because it was the first approved novel oral anticoagulant in the United States for prevention and treatment of VTE after a hip or knee replacement and shares almost forty ...
137
The effects of tissue factor pathway inhibitor and anti beta 2 glycoprotein I IgG on thrombin generation
... In contrast, anti-β2GPI and anti-prothrombin are acquired antibodies with an anticoagulant effect on in vitro TF-induced thrombin generation.20,25 Their anticoagulant activities may be m[r] ...
7
Supporting the use of a coagulometric method for rivaroxaban control: a hypothesis-generating study to define the safety cut-offs
... the anticoagulant effect of the DOAC (5) ...the drug and on the concomitant presence of potent P-glycoprotein inhibitors or ...the drug concentration and not the intensity of the drug’s ...
5
<p>Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy</p>
... detect H 2 O 2 for testing our drug delivery system. The PS/ hpGHA NPs had inhibitory effects on H 2 O 2 -induced toxicity, increasing the cell viability to 83.72%. Therefore, PS/hpGHA NPs had strong synergistic ...
17
NOACs replace VKA as preferred oral anticoagulant among new patients: a drug utilization study in 560 pharmacies in The Netherlands
... In The Netherlands, NOACs are increasingly prescribed and gained market share from VKA among existing and especially new patients. Patients treated with NOACs are in general adherent to [r] ...
10