antigen receptors
Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... With breakthroughs in synthetic biology, improved cell culture techniques and advanced genetic engineering, it has now become possible to generate bi-specific primary human T cells with desired specificities. One mode of ...
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Roles of antigen receptors and CA215 in the innate immunity of cancer cells
... to antigen receptors, seem to indirectly support the possible inter-related roles between TLRs and antigen receptors in cancer cells ...both antigen recep- tors and TLRs, as well as ...
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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
... cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some level of BCR structural restriction become ...
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HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies
... Genetic construction of chimeric antigen receptors based on broadly neutralizing antibodies against HIV-1. A set of BNAbs was selected based on the binding of different HIV-1 Env domains and the ...
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A CD19/Fc fusion protein for detection of anti CD19 chimeric antigen receptors
... Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating ...non-MHC-restricted ...
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Engineering Chimeric Antigen Receptors For Durable Control Over Hiv-1 Replication
... cell receptors (TCRs) or chimeric antigen receptors (CARs) (4, ...extracellular antigen binding domain fused to intracellular T cell activation domains ...synthetic receptors can ...
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T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells
... chimeric antigen receptors (CAR) showed re- markable curative effects in multiple tumor types, espe- cially, in the case of hematologic malignancies ...extracellular antigen-binding domain, a ...
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Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
... Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple disease ...
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... an antigen-targeting ...unique antigen-binding properties, could be stacked consecu- tively to generate a single CAR with the capacity to identify multiple ...
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New advances in leukaemia immunotherapy by the use of Chimeric Artificial Antigen Receptors (CARs): state of the art and perspectives for the near future
... markers. In fact, CARs have been generated to target these self tissue-restricted B-cell antigens [12-15]. How- ever, B-CLL hypo-gammaglobulinemia is present in approximately 8% of patients at diagnosis and progres- ...
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A phase I clinical trial of adoptive T cell therapy using IL 12 secreting MUC 16ecto directed chimeric antigen receptors for recurrent ovarian cancer
... target antigen is necessary, it may not be sufficient in creating an effective CAR against a solid tumor given the inhibitory tumor ...activated antigen-presenting cells (APCs), neutrophils, and macrophages ...
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Increased numbers of T lymphocytes with gamma delta positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis
... Individuals with sarcoidosis were evaluated for preferential usage of T cells with the gamma delta-positive (+) type of T cell antigen receptor. Compared with normal subjects (n = 19), the group with sarcoidosis ...
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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
... of antigen. For example, in some instances, high affinity antigen binding may depend on only one or a few critical amino acids ...by antigen, these “neutral” muta- tions might then result in an ...
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The P Domain of Norovirus Capsid Protein Forms a Subviral Particle That Binds to Histo-Blood Group Antigen Receptors
... viral receptors have opened a new approach to study the host range and pathogenesis (18, ...as receptors, which are complex carbohydrates present on red blood cells and mucosal epithelium or as free ...
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Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors
... after antigen removal, they mount a robust cytolytic and cytokine-production re- sponse when re-challenged with antigen-expressing tar- ...sustained antigen stimulation shows strong correlations with ...
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Chimeric antigen receptors: unleashing a new age of anti-cancer therapy
... Novel developments and current clinical trials To circumvent the challenges and present limita- tions of CAR T cell monotherapy, scientists have sug- gested the use of combinational therapies to enhance CAR efficacy. For ...
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Ultrastructural mapping of methyldopa and anti D IgG erythrocyte antigen receptors
... appropriate concentrations of the two IgG reactants. To determine if a alpha-MD IgG binds to the D-antigen receptor, D-positive red cells were sensitized with alpha-MD and [125I]anti- D IgG spearately and with ...
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The role of B cell antigen receptors in mantle cell lymphoma
... about potential BCR-interacting antigens in MCL cells not harboring superantigen-binding sites. While a few MCL BCRs might bind to autoantigens similar to bind- ing patterns described in CLL, the activation mecha- nisms ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... Chimeric antigen receptor; CDC: Complement dependent cytotoxicity; CIK: Cytokine induced killer; CRS: Cytokine release syndrome; EBV-CTL: Human Epstein Barr Virus-cytotoxic lymphocyte; EGFR: Epidermal growth ...
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Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
... Chimeric antigen receptors (CARs) are fusion proteins consisting of an antigen recognition moiety and T cell activation domains (Fig. 1). T cells can be genetically modified to express CARs and ...
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