Aurora Kinases
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
... protein kinases including polo-like kinases and Aurora ...these kinases are frequently dysregulated in cancers, small-molecule inhibitors have been developed for targeted anticancer ...and ...
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The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells <div><br /></div>
... of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor effect and underlying mechanisms in ...
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Analysis of Aurora kinases genes expression points on their distinct roles in prostate cancer development
... of Aurora kinases A and B genes positively correlated both with MkI67 and ...includes Aurora kinases’ genes) [34], we suppose that our results confirm previous ...by Aurora A ...
12
The functional diversity of Aurora kinases: a comprehensive review
... of Aurora kinases can vary in size and sequence between human Aurora proteins and phylogenic ...of Aurora proteins at the end of mitosis ...in Aurora kinases: (i) the D-boxes, ...
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Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition
... and Aurora kinases, it should be noted that MPS1 possesses a gatekeeper residue which is different to that seen in Aurora A and B ...(M602), Aurora A and B have a leucine residue (L210 in ...
9
Targeting and Characterization of Dysregulations of the Aurora Kinases A and B Family Members in Ewing Sarcoma Models.
... expression of EWS-FLI1 alone increased mitotic slippage in the HT1080 cell line (Figure. 3.12E). Our EWSR1 studies revealed preliminary indications that EWSR1 is a key regulator of[r] ...
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Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases
... Dictyostelium Aurora has the dynamic distribution of both Aurora A and Aurora B ...like Aurora A or Aurora B, we examined the dynamic localization of GFP-tagged DdAurora in live Dictyo- ...
12
Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck
... the Aurora kinases as potential targets in this disease. Aurora kinases are upregulated in multiple human cancers, correlating in some cases with poor prognosis [18, 20-21, ...both ...
11
STUDY OF THE ENZYME SUBSTRATE BY MOLECULAR MODELING INTERACTION; CASES OF THE DISEASE OF CANCER
... The Aurora kinases, a family of mitotic regulators, have received much attention as potential targets for novel anti-cancer therapeutics 6 ...years Aurora kinases have been emerged as an ...
5
ATF2 has been implicated in malignant and
... promotes Aurora signaling at the onset of M phase in a manner that is dependent on the activity of the ...phosphorylated Aurora kinases, and its related proteins, it is of interest to determine ...
7
Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases
... the Aurora kinases are a family of serine/threonine kinases that play crucial roles for cell cycle ...The Aurora family has three members: Aurora A, B and C, which are very similar ...
15
Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
... Aurora kinases are a family of serine/threonine kinases that are evolutionarily highly ...the aurora kinases is to promote mi- totic spindle assembly by regulating centrosome duplica- ...
10
AURORA BOREALIS:
... European participation in IODP warrants lead agency status. However, as the research interest in the Arctic expands, other potential contributors such as, Canada, China, Japan and the USA could be encouraged to cover ...
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CSN6 deregulation impairs genome integrity in a COP1- dependent pathway
... of Aurora A, while COP1 knockdown suppressed the expression of Aurora A (Figure ...of Aurora A in a dose-dependent manner (Figure ...while Aurora A knockdown in this COP1-overexpressing cell ...
15
Conference Proceedings: Aurora Scientific Day 2019
... from Aurora Health Care were used to identify a cohort of 564,988 patients, age 18–100 years by end of 2017, that lived in Milwaukee County for 360 or more days and had 2 or more in-person encounters between 2008 ...
15
Kinome Expansion in the Fusarium oxysporum Species Complex Driven by Accessory Chromosomes
... of kinases with respect to FOSC host-specific adaptation, we compared the kinomes of 12 Fusarium oxysporum isolates, including 10 plant pathogens, 1 human-pathogenic strain, and 1 nonpathogenic biocontrol ...99 ...
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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development
... of aurora B-deficient ...encoding aurora B contains eight exons (boxes) containing non-coding (open boxes) or protein-coding (gray boxes) ...flank aurora B exons or the neo-resistance cassette ...
12
The importance of ERBB receptor tyrosine kinase signaling in colorectal cancer : implications for EGFR-targeted therapies
... Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the United States. Our current understanding of the molecular pathways associated with this malignancy has led to the development of novel ...
146
Aurora Borealis
... a life, predestiny had forged together: path Okie spirit, inspiration for the of part the life out life to that and understand Enter Jacques Lassaignes "Chagall refuses "to be dominated;[r] ...
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Chan, Ho Yee (2007): Exploring the regulation and function of human Lats1 and Aurora A kinases in mitosis. Dissertation, LMU München: Fakultät für Biologie
... To study the cell-cycle regulation of hBora, HeLaS3 cells were arrested at G1/S (thymidine block) or prometaphase (nocodazole) and analyzed at different time points after release (Fig. 23A and B, respectively). As ...
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