B-acute lymphoblastic leukemia
Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... Therapy-related acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...therapy-related acute myeloid ...
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Childhood B-acute lymphoblastic leukemia: a genetic update
... in epigenetic regulators (discussed more below) [97]. Epigenetic studies have also shown insights into our understanding of MLL-rearranged B-ALL. MicroRNAs (miRNAs), short noncoding RNAs involved in the regulation ...
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... precursor B leukemic cells is related to the clinical course, cell profile, and ...In acute lymphoblastic leukemia, it was reported that CD90+/CD110+ cells in acute lymphoblastic ...
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Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses
... breast and 12.6±2.5 kPa for the right breast (Figs. 1-2). Shear wave sonoelastography provides quantitative elasticity measurements, thus adding complementary information that potentially could help in breast lesion ...
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... than B-ALL patients [8, 10, ...established leukemia groups [19 – ...on B-ALL, whereas MRD studies in T-ALL were ...of leukemia cells was found in T-ALL pa- tients and MRD risk group classified ...
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Molecular genetics of B precursor acute lymphoblastic leukemia
... in B-ALL is the t(12;21) (p13;q22) rearrangement that encodes ETV6-RUNX1 ...in leukemia and other malignancies ...in acute myeloid leukemia (7), and harbors sequence mutations in myeloid and ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), multiple myeloma (MM), and B cell lymphomas ...and ...
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Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... ALL: acUte lymphoblastic leukemia; AML: Acute myeloid leukemia; BCL-6: B-cell lymphoma 6 protein; Bmi1: B cell-specific Moloney murine leukemia virus integration ...
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The Philadelphia chromosome in leukemogenesis
... positive leukemia [8–10]. Leukemia stem cells and BCR- ABL kinase domain mutations may be the keys to solve these problems ...of acute myeloid leukemia (AML) [12, 13], acute ...
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Landscape of gene fusions in epithelial cancers: seq and ye shall find
... ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; APL: Acute promyelocytic leukemia, cholangio cholangiocarcinoma; CML: Chronic myeloid leukemia; CRC: ...
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T cell receptor gamma and delta rearrangements in hematologic malignancies Relationship to lymphoid differentiation
... T cell receptor delta gene recombinatorial events were found in 91% of acute T cell lymphoblastic leukemia, 68% of non-T, non-B lymphoid precursor acute lymphoblastic leukemia ALL and 80[r] ...
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Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
... Immunophenotyping was performed on BM sample using a general panel of fluorescent antibodies against the following antigens typical for different cell lineages and cell types: CD1a, CD2, CD3, CD4, CD5, CD8, CD10, CD11b, ...
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A high complex karyotype involving eleven chromosomes including three novel chromosomal aberrations and monoallelic loss of TP53 in case of follicular lymphoma transformed into B-cell lymphoblastic leukemia
... common B- cell non-Hodgkin’s lymphoma (NHL) with a relatively indo- lent clinical course, accounting for 20–30% of all NHL ...large B-cell lymphoma (DLBCL) [2]. Furthermore, lymphoblastic lymphoma ...
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... Latar belakang: Angka kesintasan leukemia limfoblastik akut (LLA) anak di Indonesia masih rendah. Ketepatan stratifikasi risiko merupakan hal penting dalam meningkatkan kesintasan. Di negara maju, stratifikasi ...
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Immunotherapy in hematologic malignancies: past, present, and future
... on B cell malignancies); tumor sampling is straightforward and less invasive than in solid tumors, as discussed previ- ously; and importantly, there is already a natural homing of T cells to the areas where the ...
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CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
... After confirming the specificity and reactivity of CLL-1 CAR-T cells against human AML in vitro, we further assessed their anti-leukemic activity in vivo. We first de- veloped a xenogeneic model of systemic AML using the ...
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Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
... Allogeneic stem cell transplantation (allo-SCT) repre- sents a curative option for intermediate- and high-risk adult acute leukemias (AL). In the absence of a matched donor, haploidentical donors are increasingly ...
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Protein kinase inhibitors for acute leukemia
... Protein kinases are conventionally divided into five clas- ses: protein tyrosine kinase, protein serine/threonine kinase, tryptophan protein kinase, histidine protein kin- ase and protein aspartyl/glutamoyl kinase. It ...
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Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies
... The significance of angiogenesis in blood cancers, such as leukemia, has been noticed since it plays an important role in both hematopoiesis and leukemogenesis [142]. Several miRNAs have been identified and ...
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Acute Leukemia Classification based on Image Processing and Machine Learning Techniques
... In the first step, the blood smear image is acquired from the database and converted to the L*a*b* color space in the second step [13]. Then the Otsu’s method is used to extract the WBCs from the b* ...
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