BCL-2/BAX ratio
Differential mRNA expression of the main apoptotic proteins in normal and malignant cells and its relation to in vitro resistance
... of Bcl-2 family as key players in intrinsic apoptosis have significant impact on survival and may significantly affect sensitivity of malignant cells to different types of chemotherapy ...of ...
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Original Article Polyenylphosphatidylcholine alleviates palmitic acid-induced apoptosis in HepG2 cells via inhibiting endoplasmic reticulum stress
... of Bax was increased and that of Bcl-2 was decreased after incubating with PA or/and PPC for 24 h (Figure ...2). Bax expres- sion in PA/PPC co-treatment group was remark- ably less than ...
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Original Article MiR-204 inhibits hypertension by regulating proliferation and apoptosis of vascular smooth muscle cells
... declined Bcl-2/Bax ratio in VSMC, promoted cell apopto- sis, reduced VSMC number and cross sectional area of vascular media, and declined blood pressure in mouse hypertension model, sug- ...
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Discrimination of the Effects of Doxorubicin on Two Different Breast Cancer Cell Lines on Account of Multidrug Resistance and Apoptosis
... DOX. Bax/Bcl-2 ratio increased significantly upon application of 200 nM of the ...gene Bax clearly augmented upon treatment with 400 and 800 nM of the drug in MDA-MB-231 ...
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Swainsonine Activates Mitochondria-mediated Apoptotic Pathway in Human Lung Cancer A549 Cells and Retards the Growth of Lung Cancer Xenografts
... h), Bax protein levels in- creased, whereas Bcl-2 protein levels decreased gradually with ...the ratio of Bax/Bcl-2, which is in favor of the occur- rence of ...of ...
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Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate
... Our study shows that DPI, an inhibitor of NADPH oxi- dase, suppresses H. pylori-induced cell death, hydrogen peroxide production, DNA fragmentation, increase in the ratio of Bax/Bcl-2, and p53 ...
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Surfactin-based nanoparticles loaded with doxorubicin to overcome multidrug resistance in cancers
... the ratio of Bax/Bcl-2 gene expression in MCF-7/ADR cells compared to that with free DOX, suggesting that DOX@SUR nanoparticles had stronger ability to inhibit proliferation and induce ...
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Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
... the ratio of Bcl- 2/Bax proteins in the mitochondria ...of Bax and the related protein was held at bay by the formation of complexes with anti-apoptotic pro- tein, ...signals, ...
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Association of Bax and Bcl 2 Functional Polymorphisms and Protein Levels with Posttraumatic Stress Disorder
... apoptosis-related Bcl-2 and Bax proteins with PTSD as well as proteins levels in the blood of affected ...disorders. Bax and Bcl-2 proteins levels in blood were measured by ...
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N-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87
... decreasing Bax-Bcl-2 ratio. Bax in itself does not cause cell death, but its elevated expression favors an entry into the apoptotic program following a death signal by countering ...
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Effect of carbamylated erythropoietin on neuronal apoptosis in fetal rats during intrauterine hypoxic-ischemic encephalopathy
... lymphoma 2 (Bcl-2) and Bcl-2 Associated X Protein (Bax) expression levels in the brain cells at different time points after ...in Bcl-2 and Bax expression ...
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Preclinical evaluation of recombinant human IFNα<sub>2</sub>b-containing magnetoliposomes for treating hepatocellular carcinoma
... about 2 mm in diam- eter on ice, placed into a tube containing solution A (10 mM Tris acetate, 6 mM 2-mercaptoethanol, 1 mM ethylene glycol tetraacetic acid, 4 mM MgCl 2 , ...antihuman ...
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Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... the Bcl-2 family and the activation of caspases [34–35]. The Bcl-2 family proteins are key components of the cascade reaction of mediated ectophragm permeability apoptosis ...apoptotic ...
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Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice
... by Bcl-2 family members, is the most important intracellular apoptosis signaling ...cascade. Bcl-2 family, as a group of crucial regulatory factors in apoptosis, can indirectly regulate the ...
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Effects of Photodynamic Therapy Using Yellow LED-light with Concomitant Hypocrellin B on Apoptotic Signaling in Keloid Fibroblasts
... The BCL-2 family by composition of BCL-2 protein and its homologues plays an essential role in the regulation of cell death and cell survival ...and BAX has been suggested to regulate ...
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Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
... Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial ...of ...
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Studying of the Expression of BAX and BCL-2 Genes in Men with Sperm DNA Fragmentation Based on DFI and Comet Assay
... high Bax/Bcl ratio shows the pro-apoptotic tendency of the cell ...of Bax increases and Bcl-2 de- creases, the suitable pro-apoptotic environment is pre- pared for the cell ...
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Interaction of Memantine with Homocysteine on the Apoptosis in the Rat Hippocampus cells
... of Bax, Bcl-2, and the activation of Caspase 3 in the rat hippocampus ...of Bax and Caspase-3 immunoreactivity in hippocampus of rat brain in Hcy ...in Bax/Bcl-2 ...
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Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
... of Bax and Bcl-2 was determined through real-time polymerase chain reaction by using ΔΔCt method of relative ...Results: Bax and Bcl-2 expression among marrow and blood samples ...
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Evaluation of Apoptotic Genes Expression and Its Protein after Treatment of Cryptorchid Mice
... A greater understanding of these signaling pathways is emerging from studies of the spermatogenic defects [3]. Testicular hyperthermia provides an in vivo model system to study the regulation of a form of stress- induced ...
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