Bcl-xL/Bax
Original Article The expression of ERβ2, Bcl-xl and Bax in non-small cell lung cancer and associated with prognosis
... ERβ2, bcl- xl and bax were expressed in NSCLC ...ERβ2, bcl-xl and bax were over-expressed in NSCLC obviously through the ...and bcl-xl, bax ...both ...
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Adenoviral Transfer of mda-7 Leads to BAX Up-regulation and Apoptosis in Mesothelioma Cells, and is Abrogated by Over-expression of BCL-XL
... caspase, BCL-XL, BAK, and BAX antibodies were obtained from Santa Cruz Biotechnology, ...CA). BCL-2 anti- body was obtained from Dako Corporation (Carpen- teria, ...follows: BAX 1:500, ...
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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
... of Bax from the cytosol to the mitochondria in sh-DJ-1 cells (Figure 5C and ...less Bax was presented in the mitochondrial fraction in cells transfected with Flag-DJ-1(s), but more Bax was present in ...
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Vesicular Stomatitis Virus Induces Apoptosis Primarily through Bak Rather than Bax by Inactivating Mcl-1 and Bcl-XL
... Since Bid is cleaved primarily by caspase-8, the experiments shown in Fig. 8 were extended by treating HeLa cells with a caspase-8 inhibitor to determine whether the rate of VSV- induced apoptosis was decreased. HeLa ...
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A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke
... (1:200; Santa Cruz Biotechnology), PECAM-1 (1:200; Santa Cruz Biotechnology), selectin (1:200; Santa Cruz Biotechnology), CXCR4 (1:200; R&D Systems), β1-integrin (1:200; Chemicon), β2-integrin (1:200; Chemicon), ...
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<p>Acetyl-11-Keto-β-Boswellic Acid Exerts the Anti-Cancer Effects via Cell Cycle Arrest, Apoptosis Induction and Autophagy Suppression in Non-Small Cell Lung Cancer Cells</p>
... in Bax -mediated ...of Bax and downregulation of Bcl-xl, indicating that AKBA exerted the anti-cancer effects by inducing cell apoptosis via inhibition of PI3K/Akt path- ...
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Original Article Clusterin (apolipoprotein J) facilitates NF-κB and Bax degradation and prevents I/R injury in heart transplantation
... Proteins were isolated from total cells using 14,000×g centrifugation for 10 minutes at 4°C and the supernatant was collected; nuclear fractions were isolated using a Nuclear/Cytosol Fractionation Kit (BioVision, Inc., ...
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Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... the Bcl-2 family and the activation of caspases [34–35]. The Bcl-2 family proteins are key components of the cascade reaction of mediated ectophragm permeability apoptosis ...apoptotic Bax family ...
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Evidence for Involvement of BH3-Only Proapoptotic Members in Adenovirus-Induced Apoptosis
... BH3-only BCL-2 family proapoptotic ...protein BCL-xL and its mutants expressed from the E1B region of the Ad5 ...a BCL-xL mutant (mt1) deficient in interaction with multidomain ...
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Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
... of Bax and Bcl-2 failed to reach statistical ...especially Bax and Bcl-2 ...of Bax and Bcl- 2 proteins. Prognostic and predictive role of Bcl-xl gene expression in ...
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Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer
... Bak: Bcl-2 homologous antagonist/killer; Bax: Bcl-2-associated X protein; EBV: Epstein-Barr virus; LMP-1: Latent membrane protein 1; LMP-2A: Latent membrane protein 2A; EBER-1: EBV encoded small ...
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A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function
... other Bcl-2 family members (Figures 13 and 15), it abrogated the co-localization of Puma with both Mitotracker ® Red CMXRos stain and Tomm-20 (Figures 9 and ...to Bcl- xl or Bax (Figures 13 ...
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Suppression of lung cancer progression by biocompatible glycerol triacrylate– spermine-mediated delivery of shAkt1
... MA). Bax, Bcl-xL, proliferating cell nuclear antigen (PCNA), Cyclin B1, vascular endothelial growth factor (VEGF), and Actin antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, ...
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Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice
... (3498T), Bcl-xl (2764T), Bax (14796S), Bak (12105T), caspase-9 (9508T), cleaved caspase-8 (8592T), cleaved caspase-7 (8438S), cleaved caspase-6 (9761T), cleaved caspase-3 (9664T) antibodies, rabbit ...
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Cusack_unc_0153D_14350.pdf
... the Bcl-2 family proteins have been shown to modulate axon degeneration as deficiency of Bax or overexpression of anti-apoptotic protein Bcl-XL both protect axons following axon-specific nerve ...
253
Differential mRNA expression of the main apoptotic proteins in normal and malignant cells and its relation to in vitro resistance
... of Bcl-2 protein, p53 induction and the induction of apop- tosis ...of Bcl-2, in all of the studied cell lines. The level of Bcl-2 was asso- ciated with chemoresistance in lymphoma cell lines, but ...
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Hederagenin from the leaves of ivy (Hedera helix L ) induces apoptosis in human LoVo colon cells through the mitochondrial pathway
... CGTCACCGGAGTCCATCA; Bax forward primer, TTT GCTTCAGGGTTTCATCC, Bax reverse primer, GCCAC TCGGAAAAAGACCTC; Bcl-2 forward primer, ATGAA CTCTTCCGGGATGG, Bcl-2 reverse primer, TGGATCC ...
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Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle cell lymphoma
... Accumulating data indicate that the microenvironment is a critical factor for cancer cell survival and thus has to be considered for the development of successful new treatment strategies. In this respect, special ...
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Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation
... between Bcl-xL and tumor progression and patient ...that Bcl-xL may be a good prognostic tool to identify patient outcome and response to chemotherapy, independent of MGMT ...the Bcl-2 ...
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Interaction of Memantine with Homocysteine on the Apoptosis in the Rat Hippocampus cells
... The aim of this study was to investigate the neurotoxicity of Hcy on hippocampus cells. Hcy (0.5 µmol) was directly injected in rat hippocampus and programmed cell death (apoptosis) was analyzed by Immunohistochemistry ...
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