bh3-only proteins
The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis
... vBcl-2 proteins have been shown to interact with one or more of the BH3-only ...other BH3-only proteins ...certain BH3-only proteins to inhibit apoptosis ...
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Apoptosis inducers in chronic lymphocytic leukemia
... upregulate BH3-only proteins in CLL Although DNA-damaging chemotherapy is thought to kill tumor cells mainly through the p53 pathway, the mechanisms involved have still not been unambiguously ...not ...
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Boolean network-based model of the Bcl-2 family mediated MOMP regulation
... Bcl-2 proteins can be categorized according to the number of Bcl-2 homology domains (BH) in their α-helical regions ...to BH3-only proteins and multidomain proteins - effectors ...[8]. ...
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The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function.
... the BH3 domain in isolation ...the BH3 peptides with the anti-apoptotic and pro-apoptotic-effector Bcl-2 proteins have been studied thoroughly in vitro, however, the BH3-only ...
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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT 737
... family proteins are expressed in many cancers, but the circumstances under which these proteins are necessary for tumor maintenance are poorly ...antiapoptotic proteins, a strategy we call BH3 ...
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VEGF B inhibits apoptosis via VEGFR 1–mediated suppression of the expression of BH3 only protein genes in mice and rats
... proapoptotic BH3-only proteins and other apoptosis- and cell death– related proteins, including p53 and members of the caspase family, via activation ...
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New dimension in therapeutic targeting of BCL-2 family proteins
... these proteins proves to be an attractive strategy for anticancer ...that BH3-only members of the family are specific antagonists of prosurvival ...the BH3 domain of BH3-only ...
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Evidence for Involvement of BH3-Only Proapoptotic Members in Adenovirus-Induced Apoptosis
... for BH3- only proteins were obtained from various commercial sources: rabbit polyclonal BIM (Pharmingen), NOXA, BIK, BID, and BNIP3-L (Santa Cruz Biotechnol- ogy), UREB1/LASU1/MULE (MCL1 ubiquitin E3 ...
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A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function
... these proteins localize to membranes in order to increase the chances of coming near enough to each other to ...other proteins (Lalier et ...other proteins. Indeed, the BH3-only ...
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Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L
... proapoptotic proteins Bak and Bax are regulated by antiapoptotic Bcl-2 proteins and are also activated by a subset of proteins known as BH3-only proteins that perform dual ...
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Activation of Tumor Suppressor Protein p53 Is Required for Theiler's Murine Encephalomyelitis Virus-Induced Apoptosis in M1-D Macrophages
... binds only to Mcl-1 and A1 (2). After the binding of proapoptotic BH3-only proteins to pro- survival Bcl-2 family members, degradation of the prosurvival proteins releases Bak/Bax, ...
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Sequence and partial functional analysis of canine Bcl 2 family proteins
... dog only two out of these six BH domains showed one aa ...two BH3-only proteins Bad and ...these proteins between murines and humans yielded 58% and 34% identity for Bad and Noxa, ...
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Insulin like growth factor 1 attenuates antiestrogen and antiprogestin induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3 only pro apoptotic protein Bim
... Breast cancer is a leading cause of cancer among women in the United States and approximately 60% to 70% of these breast cancers express estrogen receptor alpha (ERa) [1-3]. Estrogen binding to ERa induces both genomic ...
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Cell Differentiation and Gene Expression Combined
... In each cell, only some of the genes are active, or expressed. The activity of genes in a cell is called gene expression. In this activity, you will explore how some genes are turned on and off by molecules called ...
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Fueling ab initio folding with marine metagenomics enables structure and function predictions of new protein families
... Despite the remarkable success, most of the approaches generated contact-maps using unified sequence databases from microbial genomes (IMG) or UniProt. Specific ge- nomes from the ocean microbiome, one of the richest ...
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Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy
... of proteins that are broadly divided into pro-apoptotic and anti-apoptotic ...Bcl-2 proteins occur at the BH3 domains [24, 25]. BH3 profiling measures the relative interactions of pro- and ...
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Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4
... these proteins belong to a same stress- induced multi-chaperone system, which is important for the folding of newly synthesized polypeptides ...of proteins was also ...tory proteins in an open ...
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Retrovirus Restriction by TRIM5 Proteins Requires Recognition of Only a Small Fraction of Viral Capsid Subunits
... TRIM5 proteins form intra- cellular complexes known as cytoplasmic bodies, which can be observed as punctate structures by immunofluorescence micros- copy (19, ...
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Zimmerman_unc_0153D_12103.pdf
... The BCR-Abl inhibitor imatinib is a successful front-line treatment for chronic myelogenous leukemia (CML). However, despite the success of imatinib, multiple mechanisms of resistance remain a problem, including ...
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Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
... With a development of patient screening tools and a re- search on pathways involved in tumorigenesis, anti- cancer drug research was developed by converting from chemotherapy inducing cytotoxic responses to target ...
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