Binding Specificity
Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6
... receptor binding sites of two of the three monomers in the asymmetric ...analog binding in the FIG 2 Phylogenetic tree and overall ...receptor binding domain was used as a representative of the ...
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Receptor binding specificity and origin of 2009 H1N1 pandemic influenza virus
... compensated for N125D. We quantitatively investigated how mutations A30V, D94N, N125D, and V250A in the HA protein of this variant may affect its HA receptor binding affinity. In summary, mutation A30V increased ...
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Receptor binding specificity of recent human H3N2 influenza viruses
... change binding from α2-3 to α2-6 and host cells from avian to human, or vice versa ...higher binding affinity to 6'sialyllactosamine than avian viruses ...tor binding specificity is a ...
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Selection and Characterization of DNA Aptamers with Binding Specificity for Listeria spp.
... exact binding site for the aptamer may hinder the ability to obtain accurate information about binding ...with binding specificity to a cell surface protein of Salmonella, Joshi et ...specific ...
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Diverged Binding Specificity of Rim101p, the Candida albicans Ortholog of PacC
... consensus binding sites upstream of PHR1, a RIM101-dependent, alkaline pH-induced gene of ...the binding specificity of Rim101p is different. In vitro binding studies demonstrated that Rim101p ...
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... by binding of HA1 to its host cell receptors and followed by the fusion between viral and host endosomal membranes mediated by ...receptor binding specificity from each mutation in HA1 in various ...
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The Basis for Evolution of DNA-Binding Specificity of the Aft1 Transcription Factor in Yeasts
... To confirm this important point, we performed electro- phoretic mobility shift assays with extracts from the aft1Δaft2Δ cells expressing LexA, LexA-Aft1, lexA-KlAft, or LexA-KlAft Aft1(143–215) and the probe containing ...
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Binding specificity of antiidiotypic autoantibodies to anti DNA antibodies in humans
... Human antiidiotypic antibodies to anti-DNA antibodies can be separated into at least two categories based on their binding to anti-DNA, antiidiotypic antibodies, and antigens. One type was found mainly in inactive ...
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Multimerization of Hepatitis Delta Antigen Is a Critical Determinant of RNA Binding Specificity
... RNA preparation. Transcription reaction conditions and RNA purification procedures were as previously described (8). RNAs were transcribed from PCR products into which the T7 promoter sequence was incorporated via the ...
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The antigen of hepatitis delta virus: examination of in vitro RNA-binding specificity.
... We found that the ability of the HDV genomic and antigenomic RNAs to fold into the rodlike structure was an essential feature for specific RNA binding, and we were able to detect a funct[r] ...
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Structural Basis for the Receptor Binding Specificity of Norwalk Virus
... the binding pocket and mediating the bulk of the capsid-sugar ...NV-type binding mode ...the binding pocket) for either A or B trisaccharide in the VA387 P domain reveals significant steric hindrance ...
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Structure, Receptor Binding, and Antigenicity of Influenza Virus Hemagglutinins from the 1957 H2N2 Pandemic
... receptor binding and membrane fusion, and is the major viral antigen for antibody ...human binding specificity that contributed to its introduction into the human ...microarray binding ...
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Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... Its binding site was mapped to the stem-loops 2 and 3, which are the most conserved region of the 3 * ...protein binding, while the compensatory muta- tions restored its ...consensus binding sequence ...
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Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers.
... We assayed for binding specificity of the renatured proteins by competition analysis with the LVb/core A oligonucleotide as a probe and a series of oligonucleotides containing mutations [r] ...
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cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen.
... Mutations in the phosphorylation sites of simian virus 40 SV40 T antigen alter its origin DNA-binding specificity for sites I and II and affect SV40 DNA replication activity.. Binding of[r] ...
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Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis.
... To determine whether the virus binding detected by this method represents a specific viral envelope-cell surface receptor interaction, we compared the binding specificity of ecotropic an[r] ...
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Identification of domains in rubella virus genomic RNA and capsid protein necessary for specific interaction.
... the specificity of binding is associated with a short sequence at the 59 terminus of the viral genome between nucleotides 330 and 617 ...for binding (nu- cleotides 330 to 617) was inserted, showed ...
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Mapping of Post-Transcriptional Regulatory Networks by Means of Mechanistic and High Throughput Data
... Concerning the second part of my work, we have demonstrated the HCE identification algorithm to be sensitive and specific enough to retrieve both already known (histones – SLBP) and novel post- transcriptional regulatory ...
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Core-Binding Factor Influences the Disease Specificity of Moloney Murine Leukemia Virus
... disease specificity of the ...disease specificity of the Moloney virus from T-cell leukemia to ...CBF binding sites induced leukemia following a shorter latent period than viruses with lower-affinity ...
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Kinetic analysis of N alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
... Here, via the generation of base-modified HNA nu- cleotides and their polymerization into highly functional- ized HNA sequences, we pave the way for the generation of tight binding, chemically and metabolically ...
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