Bone marrow niche
Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
... HSC niche interaction is between the CXC4 chemokine receptor (CXCR4) and its ligand, stromal cell-derived factor 1α ...and bone itself [20,21], and high levels of SDF-1α were observed recently in ...
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Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320
... of bone marrow niche remodeling for failure of normal hematopoiesis in myeloproliferative neoplasms has become increasingly evident [5, 7, 8, ...of bone marrow mesenchymal stromal cells ...
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G CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche
... trabecular bone loss fol- lowing VSG is due to impaired osteoid mineralization and bone ...the niche, VSG rapidly depletes bone marrow adipose tissue (BMAT) and expands myeloid ...
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Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
... In conclusion, this work offers novel insights into the role of Notch signaling in MM, providing the first experimental evidence that MM-derived JAGGED ligands drives IL-6 production by MM cells and surrounding BM ...
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Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma
... BM niche may derive from activation of hypoxia-regulated genes and secretion of their products (for example, HIF-1α, CD73, or AMPK) (4, 12) resulting in a gen- eral anergic status, which promotes tumor ...
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A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications
... HSC niche and the MM niche have been ...HSC niche model ...the marrow niche, in the hydrogel based system promote a high degree of mineralization and differentiation and create MM ...
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An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites
... the bone in terms of (i) osteoconductivity (porosity allowing for cell penetration and/or attachment and growth), (ii) osteogenicity (local osteoblastic mineral forma- tion allowing for matrix calcification) [18], ...
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Human bone marrow niche chemoprotection mediated by cytochrome p450 enzymes
... The majority of patients with acute myeloid leukemia (AML) and other hematologic malignancies achieve complete remissions with initial chemotherapy, but eventually relapse and die of their disease. The mechanisms ...
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Preliminary Findings in Cure of Two HAART Experienced HIV Patients by Stopping Reverse Dissemination from Bone Marrow CD4 Progenitors
... the bone marrow niche, due to absence of cellular immunity and the fact that the differentiating T-lymphocytes are highly susceptible and must extend their stay in the niche as ...the ...
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The hematopoietic stem cell niche: from embryo to adult
... adult bone marrow niche has predominantly been studied in vivo in genetic mouse models; by contrast, studies of HSC niches during embryonic development predominantly rely on ex vivo co- cultures of ...
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Diagnostic Utility of Bone Marrow Aspiration and Bone Marrow Biopsy in Hematological Practice
... We observed 89.5% positive correlation in cases of aplastic anemia 2 . Two cases of hypocellular bone marrow aspirate were not diagnosed on BMB due to suboptimal biopsy. One case of aplastic anemia ...
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A Correlative Study on Bone Marrow Angiogenesis with Bone Marrow Fibrosis and Splenomegaly.
... In the third and final method, bone marrow MVD was estimated by using computerized image analysis. The 3 hot spots used for the visual count were quantified by computer-based image analysis.A PC- ...
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Jones_unc_0153D_15774.pdf
... If BALB/c mice with BALB/c bone marrow and C57BL/6 mice with BALB/c bone marrow clear particles rapidly while C57BL/6 mice with C57BL/6 bone marrow and BALB/c mice with C57BL/6 bone ma[r] ...
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Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage in Children
... Treatment of diffuse alveolar hemorrhage after allogeneic bone marrow transplant with recombinant factor VIIa. Bone Marrow Transplant[r] ...
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CD45lowCD271high Cell Prevalence in Bone Marrow Samples May Provide a Useful Measurement of the Bone Marrow Quality for Cartilage and Bone Regenerative Therapy
... of Bone and Joint Surgery, ...in Bone Marrow Samples May Provide a Useful Measurement of the Bone Marrow Quality for Cartilage and Bone Regenerative ...of Bone and Joint ...
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Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
... and niche engage- ment events activated by PCa cells to coopt the HSC ...HSC niche is able to regulate dormancy of tumor cells for extend- ed ...HSC niche plays a crucial role in maintain- ing ...
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Mast cell–derived angiopoietin 1 plays a critical role in the growth of plasma cell tumors
... ng/ml). Bone marrow mast cells, obtained from C57BL/6 mice (National Cancer Institute), were cultured with 10 ng/ml IL-3 (these are referred to here as BMMCs) or with 100 ng/ml SCF plus 50 ng/ml IL-6 plus ...
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Autologous bone marrow cell therapy for peripheral arterial disease
... Abstract: Inadequate blood supply to tissues caused by obstruction of arterioles and/or capillaries results in ischemic injuries – these injuries can range from mild (eg, leg ischemia) to severe conditions (eg, ...
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Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial
... BMCs comprise a heterogeneous mixture of cells con- taining EPCs, HPCs, and other numerous cell types. Our study confirms that AMI not only leads to quantitative but also to qualitative changes in progenitor cells and ...
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Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide induced bone loss in vivo
... BMCs, Bone marrow cells; BMMs, Bone marrow macrophages; BV/TV, Bone volume per tissue volume; DC-STAMP, Dendritic cell-specific transmembrane protein; EEST, Ethanolic extract of ...
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