Bone Morphogenetic Protein
The extracellular regulation of bone morphogenetic protein signaling
... Tsg protein called Crossveinless (Tsg2), where it is released for signaling by the Tolloid-related protease (not ...BMP, bone morphogenetic protein; Cv2, Cv-2 (Crossveinless 2; BMPER); Sog, ...
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Bone morphogenetic protein expression in human atherosclerotic lesions
... In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture.[r] ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... of bone morphogenetic protein receptor type 2 (BMPR2), which is essential for embry- ogenesis and has been shown to play clinically-relevant roles in pulmonary vascular homeostasis and remodeling of ...
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Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells
... of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on the process of ...of bone morphogenetic protein receptor (BMPR) ...
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Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
... large bone defects is a major challenge, requiring sustained stimulation to continually promote bone formation ...locally. Bone morphogenetic protein 2 (BMP-2) plays an important role ...
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Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
... Background: Atypical iron overload without variation in the five clinically associated hereditary hemochromatosis genes is now recognized; however, their etiology remains unknown. Since the identification of iron ...
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Role of osteogenic protein-1/bone morphogenetic protein-7 in spinal fusion
... Osteogenic protein-1 (OP-1), also known as bone morphogenetic protein-7 (BMP-7), is a protein in the TGF-β family of cellular proteins that has shown potential for application in ...
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Immunohistochemical expression of osteocalcin, transforming growth factor beta 1 and bone morphogenetic protein 7 in fibrous dysplasia and ossifying fibroma of the jaw bones (a comparative study)
... increased bone mineral density. It is therefore, used as biomarker for bone formation process and also has a role in regulation of osteoblast function (Lee et ...in bone matrix, it is a regulator of ...
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Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis
... human bone morphogenetic protein-2 (Infuse, Medtronic ...ectopic bone formation and potentially cancer, leading clinicians to question the clinical benefit versus patient safety ...
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Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro
... transmitting factor in male gonads is produced, which terminates cell cycle at G1, and prevents the cells from entering meiosis (4). Whether a meiosis-inducing factor (5) or an autonomous event is required for GCs to ...
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Blockade of bone morphogenetic protein signaling potentiates the pro inflammatory phenotype induced by interleukin 17 and tumor necrosis factor α combination in rheumatoid synoviocytes
... Bone morphogenetic proteins (BMPs) are secreted signal- ing proteins which form a subgroup of the transforming growth factor-beta (TGF-β) superfamily ...Smad protein family, Smad1, 5, and 8, called ...
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The essential role of bone morphogenetic protein (BMP) signaling in organogenesis
... especially in the early steps in blood vessel formation. Since Bmper expression is first detected at E 7.0 (mid-gastrulation) 183 , Bmper null embryos are expected to survive until at least that stage. For these reasons, ...
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The role of bone morphogenetic protein-4 in the developing chick eye
... In other nervous tissue. Epidermal Growth Factor (EGF) is known to be w eakly mitogenic for rat PC 12 cells (H uff et al, 1981), but induces differentiation in the same cells transfected w ith the EG F receptor ...
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Structure and expression of the chicken bone morphogenetic protein-2 gene
... A mutation in the Bmp-5 gene has been isolated: the mouse mutant "short ear", which displays localised cartilage defects (Kingsley et al, 1992; reviewed in Kingsley, 1994). The size, shape and number of many ...
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Platelet derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects
... OG-induced bone regeneration was inhibited 17-53% in the presence of ...OG-induced bone regeneration and stimulated a soft tissue repair wound phenotype and ...
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Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review
... Bouyer at al. [14] made an experimental analysis in order to assess the effect of BMP-2 concentrations with EDC10 (ethylene imine linear poly) and EDC30 crosslinking levels. It was assessed while trying to fill ...
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Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4
... fusion protein with an exquisite ability to promote in vivo osteogen- esis, even by a single injection at the targeted site both with and without ...fusion protein is better than others, as CBD-BMP4 can ...
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Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo
... CaBMPRIA and caBMPRIB Produce Enlarged Cartilage and Proportionately Increased Bone Formation. In order to com- pare the potential functions of the type I receptors, CaA and CaB viruses were injected into the ...
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Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells
... with gentle shaking overnight. After three washes with TBS, the membranes were incubated for 1h at room temperature with the respective secondary an- tibody (horseradish peroxidase (HRP)-conjugated anti-rabbit and ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... BMP-2 and BMP-4 have been implicated in embryogenesis and morphogenesis of various tissues and organs, where they regulate growth, differentiation, chemotaxis and apoptosis of a variety of cell types, including ...
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