Bone morphogenetic protein 10
Blockade of bone morphogenetic protein signaling potentiates the pro inflammatory phenotype induced by interleukin 17 and tumor necrosis factor α combination in rheumatoid synoviocytes
... BMPs were originally identified as growth and differenti- ation factors for osteogenic cells but now are considered multifunctional proteins implicated in the development of virtually all organs and the renewal and ...
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Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells
... BMSCs were harvested from the femurs and tibias of 6- week-old male Wistar rats, using protocols approved by the Ethics Committee for Animal Experiments of Sun Yat- sen University. Briefly, bones were aseptically excised ...
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Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4
... A bone hole was made in the distal diaphysis of the femur with a 24 G needle, and CBD-BMP4, BMP4, or CBD (100 ng in 10 µ L PBS) was injected into the medullary cavity of the right femur with a 27 G ...
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“Evolving Trends in Biopolymer Based Drug Delivery Systems: An Overview” by Soruba Evangeline, Vickram Sundaram, Ramesh Pathy Manian, Sridharan Balasundaram, India.
... structural protein, which gives structure and support to the tissues connecting them with the ...extensively. 10 Collagen and its composites have been used as biomaterials due to its biodegradable ...human ...
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Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryo
... CaBMPRIA and caBMPRIB Produce Enlarged Cartilage and Proportionately Increased Bone Formation. In order to com- pare the potential functions of the type I receptors, CaA and CaB viruses were injected into the ...
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Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro
... transmitting factor in male gonads is produced, which terminates cell cycle at G1, and prevents the cells from entering meiosis (4). Whether a meiosis-inducing factor (5) or an autonomous event is required for GCs to ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... gous bone marrow stromal cells for the repair of full-thickness articular cartilage defects in humans ...with bone morphogenetic proteins (BMPs), members of the TGF-β ...endochondral bone ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... taining lentiviral particles was removed from the wells. A volume of 120 μL of fresh 10% DMEM was added to each well, and the plate was returned to the incubator. After 18–20 h, the media was removed from the ...
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Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells
... Immunostaining was performed using the same antibodies used for immunoblots. After a 1h blocking step with 10 % normal goat serum (NGS; for BMPR-IA and B) or 10% bovine serum albumin in phosphate buffer ...
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Structure and expression of the chicken bone morphogenetic protein-2 gene
... Gels for electrophoresis were cast with 1 x TAE buffer (50 x stock: 24.2 % (w/v) Tris-Cl, 57.1 % (v/v) glacial acetic acid, 10 % (v/v) 0.5 M EDTA, pH 8.0), and 1% agarose, or 0.7% low-melting point agarose. The ...
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Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
... paraffin. Serial sections 4 µ m thick were cut through the center of circular calvarial defects. Sections were stained with hematoxylin and eosin (H&E) and immunohistochemistry was performed. For immunohistochemistry ...
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The role of bone morphogenetic protein-4 in the developing chick eye
... As early as 1937, Dorris demonstrated that both w hole eyes and their separate com ponents (eyecups with or without lens, or separate pigment epithelium, neural retina or lens) taken from chick em bryos as young as 65 ...
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Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review
... large bone defect area ...poor bone quality or quantity conditions and results in poor healing as well as regeneration abilities ...the bone to the implant that usually takes several months for ...
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Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... (TGF-β), bone morphogenetic growth protein-4 (BMP-4) and so on ...fluorescent protein (GFP) migrated into the injured ovary and differ- entiated into follicle-stimulating hormone receptor ...
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Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
... with 10% trichloroacetic acid overnight at 4 °C, and the precipitate was washed with cold acetone and resuspended in SDS sample buffer (SB) (50 mm Tris pH ...SDS, 10% glycerol, ...
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Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients
... encodes bone morphogenetic protein receptor type II, which belongs to the transforming growth factor-β (TGF-β) superfamily and is involved in the regulation of cell growth and apop- ...
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The extracellular regulation of bone morphogenetic protein signaling
... Indirect effects via Sog, Tsg or Cv-2 are unlikely, as these play no obvious role during BMP signaling in the Drosophila wing disc at these stages (Shimmi et al., 2005a; Serpe et al., 2008; Vilmos et al., 2005; Yu et ...
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EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling
... Recombinant EfnB2-lentivirus transfection and its influence on proliferation and migration of hDPSCs EphrinB2-Fc has been reported to stimulate osteogenic differentiation of hDPSCs, while the influence of en- dogenous ...
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Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model
... Replication-deficient adenoviral expression vectors carrying the coding sequences of VEGF165 (reference sequence: NM_001025370.2) (ad-VEGFA) and BMP2 gene (reference sequence: NM_001200.2) (ad-BMP2) were purchased from ...
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Immunohistochemical expression of osteocalcin, transforming growth factor beta 1 and bone morphogenetic protein 7 in fibrous dysplasia and ossifying fibroma of the jaw bones (a comparative study)
... a protein relateded to the BMP family which are identified by their ability to induce de novo bone formation at non-bone sites (Eisenberg et ...
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