Bone morphogenetic protein 2
THE EFFECT OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 ON THE OSSEOINTEGRATION OF TEMPORARY ANCHORAGE DEVICES
... human bone morphogenetic protein-2 (rhBMP-2) on the ability of temporary anchorage devices (TADs) to osseointegrate was ...into 2 types of treatments: (1) sandblasted and ...
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Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
... large bone defects is a major challenge, requiring sustained stimulation to continually promote bone formation ...locally. Bone morphogenetic protein 2 (BMP-2) plays an ...
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Elevated extracellular matrix production and degradation upon bone morphogenetic protein 2 (BMP 2) stimulation point toward a role for BMP 2 in cartilage repair and remodeling
... Bone morphogenetic protein-2 (BMP-2) is one of the candi- date growth factors with good potential in cartilage tissue engineering as well as cartilage ...of bone, but since then ...
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Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis
... human bone morphogenetic protein-2 (Infuse, Medtronic ...ectopic bone formation and potentially cancer, leading clinicians to question the clinical benefit versus patient safety ...
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The in vivo and in vitro effects of bone morphogenetic protein 2 on the development of the chick mandible
... Int J DeLllio! ~I 67 81 (1997) 67 Oligillfll Arlirlr The in vivo and in vitro effects of Bone Morphogenetic Protein 2 on the development of the chick mandible SUNETRA EKANAYAKE* and BRIAN K HALL Depar[.] ...
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Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation
... Results: The results found that NPs formula prepared using blend of PLGA and PCL in 4:2 (w/w) ratio showed the best sustained-release pattern with lower initial burst, and showed up to 62.7% yield, 64.5% ...
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Dual delivery of bone morphogenetic protein-2 and basic fibroblast growth factor from nanohydroxyapatite/collagen for bone tissue engineering
... of bone mar- row mesenchymal stem cells ...of 2:1, significantly promotes the proliferation and differentia- tion of BMSCs compared with BMP-2 or bFGF use alone ...promotes bone cell ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... and bone formation when delivered as recombinant protein [38] or via genetically modified cells ...of bone marrow-derived MSCs and other effects may be seen when different cells are ...
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OSSEOINTEGRATION OF TEMPORARY ANCHORAGE DEVICES USING RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2
... subperiosteal implants for many years. In addition, titanium easily passivates to form a protective oxide layer, which allows the apposition of proteins and tissue to the metal surface [7]. Thus, titanium itself promotes ...
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Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration
... heparin derivatives, has been incorporated into biomaterials to prolong BMP-2 release in vitro and in vivo (13, 22–25) and has the added ben- efit of enhancing BMP-2 bioactivity (26, 27). Similarly, ...
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Bone regenerative effect of recombinant human bone morphogenetic protein-2 after cyst enucleation
... without bone grafts, further research regarding growth factors, osteo- blasts, stem cells, and other components is needed to understand this process more fully ...[16]. Bone defects up to 3 cm in diameter ...
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Characterization of a shorter recombinant polypeptide chain of bone morphogenetic protein 2 on osteoblast behaviour
... The cultured biomass was then harvested by crushing twice the cells in a French press and thereafter centrifuged. The pellet was resuspended at 25 mg wet weight/ml in a suspension buffer (20 mMTris–HCl [pH 8.5], 0.5 ...
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Original Article Association between bone morphogenetic protein 2 polymorphisms and osteoporotic fracture
... NCBI SNP database (http://www.ncbi.nlm.nih. gov/snp), rs967417 is mostly located in the upstream of BMP2; rs79417223 is located in the intron of BMP2, whose mutation is indel and frame-shift one. On the basis of polymor- ...
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Structure and expression of the chicken bone morphogenetic protein-2 gene
... To date, 74 TGF-P-like sequences have been identified in different species, represen ting 23 distinct genes; the evolutionary conservation of these genes across species provides support for their importance in normal ...
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Growth Factor Release from Polyelectrolyte-Coated Titanium for Implant Applications
... ABSTRACT Polyelectrolyte multilayer coatings based on poly(methacrylic acid) and poly-L- histidine were formed on anodized titanium surfaces with adsorbed bone morphogenetic protein 2 ...
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Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes
... the protein levels tend to decrease with time (Figure ...of bone morphogenetic protein 2 in the modulation of adhesion molecules at the surface of mesenchymal stem ...
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“Evolving Trends in Biopolymer Based Drug Delivery Systems: An Overview” by Soruba Evangeline, Vickram Sundaram, Ramesh Pathy Manian, Sridharan Balasundaram, India.
... structural protein, which gives structure and support to the tissues connecting them with the ...human bone morphogenetic protein 2 (rhBMP-2) was studied for bone ...
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The extracellular regulation of bone morphogenetic protein signaling
... Indirect effects via Sog, Tsg or Cv-2 are unlikely, as these play no obvious role during BMP signaling in the Drosophila wing disc at these stages (Shimmi et al., 2005a; Serpe et al., 2008; Vilmos et al., 2005; Yu ...
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The involvement of follistatin like protein 1 in osteoarthritis by elevating NF κB mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation
... disco-interacting protein 2 homolog a (DIP2a) from Drosophila was a candidate receptor for FSTL1 in endothelial cells ...TGF-β, bone morphogenetic protein (BMP)-2⁄4, and their receptors ...
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The regulation of TGFβ signal transduction
... (bone morphogenetic protein), Erk (extracellular signal-regulated kinase), LIMK2 (LIM domain kinase 2), JNK (Jun N- terminal kinase), p38 (p38 MAPK), PAR6 (partitioning-defective 6 homolog), ...
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