BRCA1-associated protein 1
Positive nuclear BAP1 immunostaining helps differentiate non- small cell lung carcinomas from malignant mesothelioma
... for BRCA1-associated protein 1 (BAP1) and also with an IHC panel we routinely use to help differentiate MM from carcinomas, which include, calretinin, Wilms Tumor 1, cytokeratin 5, ...
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Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
... BAP1: BRCA1 associated protein-1; BRAF: B-Raf proto-oncogene, serine/threo- nine kinase; ccRCC: clear cell renal cell carcinoma; cfDNA: cell-free DNA; CLL: Chronic lymphocytic leukaemia; CNA: ...
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Distinct functions of BRCA1 and BRCA2 in double strand break repair
... for BRCA1 is shown in Fig. 1. In brief, BRCA1 has been shown to be part of a genome surveillance complex termed BASC, which contains a number of pro- teins that are important for efficient DNA repair ...
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Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors
... Figure 1. AKT is activated by estrogen treatment and BRCA1 downregulation, and its inhibition rescues the abnormalities associated with the loss of ...or BRCA1 siRNA, and then treated with E2 ...
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Original Article Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells
... suppressor protein that acts as a negative regulator of tumor growth ...functional BRCA1 protein is present in normal breast epithelial tissue and is reduced or absent in some breast ...Therefore, ...
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Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy
... regulated protein” or “antioncogene” This search identified 22 TSGs including breast cancer 1 (BRCA1), tumor protein p53 (TP53), phosphatase and tension homolog (PTEN), adenomatous polyposis ...
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The Epstein-Barr Virus Replication Protein BBLF2/3 Provides an Origin-Tethering Function through Interaction with the Zinc Finger DNA Binding Protein ZBRK1 and the KAP-1 Corepressor
... finger protein ZBRK1 and the ZBRK1 corepressor KAP-1 as BBLF2/3 ...binding protein BRCA1 were shown by indirect immunofluorescence to be present in replication compartments in lytically ...
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The determination of changes in the expression of genes for selected specific transcriptional factors in in vitro ductal breast cancer cells under the influence of paclitaxel
... X protein; Bcl-2 – B-cell CLL/lymphoma 2; BRCA1 – breast cancer type 1 susceptibility protein; cDNA – complementary deoxyribonucleic acid; CTCF – CCCTC-binding factor (zinc finger ...
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PREDICTIO OF ITERACTIO BETWEE ATITUMOR COMPOUDS AD TARGET PROTIES OF DIFFERET CACERS BY I SILICO MOLECULAR DOCKIG STUDIES
... cancer associated protein, BRCA1(1JNX) from breast cancer, Bovine lipocalin allergen BOS D2 (1BJ7) from gastric cancer, crystal structure of chicken brain-type creatine kinase (1QH4) at ...
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Reactive oxygen species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen
... UIMCI/RAP80, BRCA1-A complex subunit RAP80 protein; HDGF, Hepatoma-derived growth factor; Ccdc82, Coiled-coil domain-con- taining protein 82; OSR1, Oxidative Stress Responsive 1 protein ...
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Molecular mechanisms of HPV mediated neoplastic progression
... Activator protein 1; ATM: Ataxia telangiectasia mutated; ATR: Ataxia telangiectasia and Rad3-related protein; Bax: BCL2-associated X protein; BRCA1: Breast cancer type1; BRD4: ...
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Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response
... susceptibility protein). E2F is associated with DNA in the promoter region; unphosphorylated pRb is tightly bound to E2F and attracts histone deacetylases (en- zymes cleaving acetyl groups from N-termini of ...
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Studying breast cancer on a genomic scale using DNA microarrays
... detect tumor cells in the autologous transplant. The extremely low frequency of bone marrow tumor cells greatly hampers approaches to obtain more specific infor- mation on their biological properties. The tools ...
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Lack of EGFR activating mutations in European patients with triple negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles
... class 1 SNP and was unambiguously detected by HRM in three samples, whereas no T > G substitution (class 2 SNP), which corresponds to the EGFR L858R activating mutation, was ...
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Mitophagy and cancer
... fusion protein Opa-1 thereby reducing the size of mito- chondria, a consequence that is likely to favor uptake of mitochondria by phagophore membranes while also link- ing mitochondrial turnover to loss of ...
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Downregulation of selenium binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma
... Selenium is an essential trace element for a lot of bio- logic processes and possesses anti-carcinogenic proper- ties. Forty years ago, supplemental dietary selenium was found to play an important role in decreasing ...
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BRCA promoter methylation in sporadic versus BRCA germline mutation related breast cancers
... 39 BRCA1 and 33 BRCA2 germline mutation-related breast cancer resection specimens (BRCA1/2-C) were derived from the pathology archives at the University Medical Center Utrecht, University Medical Center ...
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Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis
... α-tubulin, 1:1,000 (T-6793; Sigma-Aldrich, St. Louis, MO); anti- Arl13b, 1:1,000 (a gift from ...anti-Cluap1, 1:1,000 (generated as described above); and anti_ShhN, 1:1,000 (5E1, Developmental ...
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Breast Cancer Genetics
... BRCA1 mutation carriers have an increased risk of a number of other malignancies and these include cancers of the uterine body and cervix, pancreatic cancer and to a lesser extent prostate cancer. cancers at other ...
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Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll like receptors
... activated protein kinases [59], stress activated protein kinases [60], p38 kinases [61], and phosphatidylinositol 3-kinase [62]) are activated by ...activated protein kinase, for example, which ...
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