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C57BL/6

Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

... the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 ...

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Original Article Effects of capsaicin on the cholesterol lithogenesis in the gallbladder of C57BL/6 mice

Original Article Effects of capsaicin on the cholesterol lithogenesis in the gallbladder of C57BL/6 mice

... of C57BL/6 and then: 1) the total bile acid, total cholesterol and phospholipids in the bile were measured, and cholesterol saturated index (CSI) was calculated; 2) the total choles- terol (T-CHO), ...

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A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

... the C57BL/ 6 mouse strain, the preferred strain for genetic modification [11] has been shown to be resistant to developing CKD by subtotal nephrectomy ...

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Loci predisposing to autoimmunity in MRL Fas lpr and C57BL/6 Faslpr mice

Loci predisposing to autoimmunity in MRL Fas lpr and C57BL/6 Faslpr mice

... and C57BL/6-Faslpr (minimal disease), four loci were identified with significant linkage to lymphadenopathy and/ or splenomegaly on chromosomes 4, 5, 7, and 10, which were named lupus in (MRL-Faslpr x ...

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Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice

Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice

... Although C57BL/6 is an inbred mouse strain, strong phenotypic variations between male mice at different ages in response to exposure to a high-fat [79] or medium-fat (Rusli et ...middle-aged C57BL/6J ...

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KARANJIN AMELIORATE DSS INDUCED COLITIS IN C57BL/6 MICE

KARANJIN AMELIORATE DSS INDUCED COLITIS IN C57BL/6 MICE

... DSS induced colitis histologically shows mucosal and submucosal lymphocyte, macrophages, polymorphonuclear leukocyte, tissue mast cell infiltration, destruction of epithelial architecture with loss of epithelial ...

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Heme oxygenase-1 activity is involved in the control of Toxoplasma gondii infection in the lung of BALB/c and C57BL/6 and in the small intestine of C57BL/6 mice

Heme oxygenase-1 activity is involved in the control of Toxoplasma gondii infection in the lung of BALB/c and C57BL/6 and in the small intestine of C57BL/6 mice

... The principal function of HO-1 is to avoid the accu- mulation of free heme [28], and HO-1 is inducible by numerous stimuli, such as NO, cytokines and growth factors, metalloporphyrins, hydrogen peroxide and lipid ...

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Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice

Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice

... Female C57BL/6 J mice (8 weeks of age; Jackson Laboratory, Bar Harbor, ME, stock # 000664) were randomly assigned to receive, ad libitum, either a high-fat (HF; 60% kcal from fat; D12492, Research Diets, ...

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Novel Attenuated Chikungunya Vaccine Candidates Elicit Protective Immunity in C57BL/6 mice

Novel Attenuated Chikungunya Vaccine Candidates Elicit Protective Immunity in C57BL/6 mice

... Several mouse models have been used to study CHIKV infec- tion (reviewed in reference 41), including mice devoid of type 1 interferon or CD8 T cell activity (42, 43). We and others have used s.c. infection with CHIKV in ...

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Response of C57Bl/6 mice to a carbohydrate-free diet

Response of C57Bl/6 mice to a carbohydrate-free diet

... Remarkable in the current study is the non-linear cal- oric response. The mice in this study showed a substan- tially greater increase in fat per calorie consumed than predicted by the standard “calorie-is-a-calorie” ...

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Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice

Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice

... MWCNT aspiration in a mouse model [21]. Current proposed guidelines by the National Institute for Occupational Safety and Health (NIOSH) limits expo- sure to 7 μ g/m 3 , the lowest detectable level of airborne CNT using ...

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Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

... Upon arrival, mice were randomly divided into either same-strain (n = 60 total, 20 of each strain) or mixed- strain (n = 20) trios. Mixed-strain trios consisted of one mouse of each strain. Mice were also split between ...

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Effect of age and vaccination on extent and spread of Chlamydia pneumoniae infection in C57BL/6 mice

Effect of age and vaccination on extent and spread of Chlamydia pneumoniae infection in C57BL/6 mice

... Effect of age and vaccination status on spread of C. pneumoniae to the cardiovascular system Cardiovascular infection is a common sequella of respira- tory C. pneumoniae infection in both C57BL/6 (Figure 2) ...

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CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice

CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice

... Figure 6: Jurkat cells were stimulated using con A (4 μg/mL) and CCR5 was inhibited using DAPTA (10 μM). Con A treatment enhanced cell viability (MTT assay) A. and proliferation (BrdU assay) B. compared to ...

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Differential expression of neurotrophins in postnatal C57BL/6 mice striatum

Differential expression of neurotrophins in postnatal C57BL/6 mice striatum

... Changes in neurotrophic factors during postna- tal development may reveal differential nourishment requirements for cell populations in the neostriatum. BDNF is transported from the cortex to the neostria- tum along the ...

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Age matters:  Young T lymphocytes offer better protection from myeloma proliferation

Age matters:  Young T lymphocytes offer better protection from myeloma proliferation

... wild-type C57BL/6 mice was seen more frequently in 18 – 20 month old wild-type C57BL/6 mice and in 3 – 4 month old Rag1-deficient C57BL/6 ...Rag1-deficient C57BL/6 ...

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Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency

Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency

... measured in LCAT KO samples while maintained on standard chow diet. However, LpX cholesterol was detected in all pooled plasma samples after starting Paigen HF/HC diet, and increased with time on diet, consistent with ...

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Effect the host and donor genotype on production of twin mice by tetraploid complementation technology

Effect the host and donor genotype on production of twin mice by tetraploid complementation technology

... used C57BL/6, C57BL/6 albino and CD1 genotype ...(CD1, C57BL/6 albino) and donor (CD1/EGFP, C57BL/6) embryo genotype regarding to the number of the living ...and ...

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Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers

Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers

... example, the susceptibility allele of the QTL on chromosome 12 is recessive, consistent with its identity as a self antigen encoded by the Igh locus, in a model of self-tolerance where heterozygous expression of the ...

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Altered gut microbiome promotes proteinuria in mice induced by Adriamycin

Altered gut microbiome promotes proteinuria in mice induced by Adriamycin

... dysbiosis’, (i.e., the reduction of Turicibacter and Mar- vinbryantia, and the increase of Odoribacter) induced a disruption of the epithelial barrier, ultimately resulting in an increased serum IL-2 level. The renal ...

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