Ca2+ release
Structural and stoichiometric determinants of Ca2+ release-activated Ca2+ (CRAC) channel Ca2+-dependent inactivation
... A conservative mutation to aspartate (E106D) [44,62,65] , or of the homologous residue in Drosophila Orai (E180D) [44,68] , produces a channel that retains activation by store depletion [r] ...
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Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca2+ release channel
... micromolar Ca 2+ concentrations, reduction in RyR2 protein levels and sarcoplasmic reticulum Ca 2+ sequestration, and upregulation of genes and/or proteins associated with class II histone deacetylase/myocyte enhancer ...
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FKBP12 activates the cardiac ryanodine receptor Ca2+ release channel and is antagonised by FKBP12 6
... there is general agreement with the idea that FKBP12.6 can ‘stabilize’ or reduce cardiac SR Ca 2+ -release under pathological conditions. In heart failure, for example, there is an increased tendency for the ...
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Cell cycle control of endoplasmic reticulum structure and Ca2+ -release in the mouse oocyte and early embryo
... Whilst exit from meiosis II (at fertilisation) remains by far the best studied example of a role for Ca^^ in cell cycle progression, there is much evidence that Ca^^ serves to trigger cell cycle transitions during ...
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cAMP potentiates InsP3-induced Ca2+ release from the endoplasmic reticulum in blowfly salivary glands
... Since almost nothing is known regarding whether cAMP affects InsP 3 R function in invertebrates or its possible mode of action, we have studied this interaction in iso- lated salivary glands of the blowfly Calliphora ...
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Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell
... synaptic transmission at the lobster neuromuscular junction (Miwa et al. 1987, 1993), while a pertussis-toxin-insensitive mGluR mediated presynaptic inhibition at the crayfish neuromuscular junction (Shinozaki and ...
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Impaired Ca2+ release contributes to muscle weakness in a rat model of critical illness myopathy
... 2+ release and re-uptake by the sarcoplasmic reticulum (SR) also contribute to the muscle weakness [5, ...and release Ca 2+ into the ...2+ release is sig- nificantly ...
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Full term mouse development by abolishing Zn2+ dependent metaphase II arrest without Ca2+ release
... Batches of oocytes were typically injected within 15 minutes and activation immediately induced by exposure to SrCl2 Perry et al., 2000, ethanol or TPEN followed by washing in KSOM and c[r] ...
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Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice
... Here, we report that generalized tonic-clonic seizures do indeed occur in a knock-in mouse model of a RYR2 missense mutation R2474S found in CPVT patients 22 and provide evidence support[r] ...
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Azadirachtin induced apoptosis in the prothoracic gland in Bombyx mori and a pronounced Ca2+ release effect in Sf9 cells
... hormone release, which may in turn regulate the haemolymph ecdysteroid level, and eventually regulate insect growth ...the release of neurosecretory materials, including prothoracicotropic hormone, and ...
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Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia
... Significantly, while the unique molecular and anatomic adaptive response to Casq2 deletion maintains functional SR Ca2+ storage, lack of Casq2 also causes increased diastolic SR Ca2+ lea[r] ...
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β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata
... 2+ release of car- diac ryanodine receptors (RyR2s) and Ca 2+ uptake through sarcoplasmic reticulum Ca 2+ pump, therefore enhancing both contraction and relaxation with fear, stress, exercise or ...2+ ...
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Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development
... Importantly, injection of Plcz1-ΔC2 mRNA, which lacks [Ca2+]i their role in this process remains unconfirmed, as neither of these oscillatory activity 13, failed to induce egg activation[r] ...
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Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos
... 2⫹ release is also regulated in a cell cycle-dependent manner where it is increased in MII and in the first ...2⫹ release have implications for understanding meiotic and mitotic control of ER structure and ...
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CRAYFISH SKELETAL MUSCLE REQUIRES BOTH INFLUX OF EXTERNAL Ca2+ AND Ca2+ RELEASE FROM INTERNAL STORES FOR CONTRACTION
... Summary The isometric tension and membrane potential of single skeletal muscle fibres from the flexor muscle of the carpopodite in the meropodite of crayfish Procambarus clarkii Girard w[r] ...
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TPC2 is a novel NAADP sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+
... are decreased. Importantly, activation by NAADP becomes reversible at luminal pH 4.8 (Fig. 4a, third trace), and the con- centration-response relationship becomes bell-shaped (Fig. 4b), as is widely observed for ...
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Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy
... Autophagy is an important cell-biological process responsible for the disposal of long-lived proteins, protein aggregates, defective organelles and intracellular pathogens. It is activated in response to cellular stress ...
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Animal Ca2+ release activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators
... In order to gain confirmatory evidence for homology between CDF carriers and Orai channels, the HMMER package was used to derive consensus sequences for both families, and these were ali[r] ...
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Attenuated Ca2+ release in a mouse model of limb girdle muscular dystrophy 2A
... 2+ release studies were performed in aged C3KO mice (1 year old) using the permeant form of fura2-FF (fura2-FF AM, Teflabs, Texas, USA) in conjunction with video micros- copy and a limited electrophysiological ...
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Cry1Ac, a bacillus thuringiensis toxin, triggers extracellular Ca2+ influx and Ca2+ release from intracellular stores in Cf1 cells
... We demonstrated that active toxins triggered Ca2+ surges which were produced largely by the influx of extracellular Ca2+ through toxin-made membrane pores but also by a small component o[r] ...
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