Carboxyl-terminal domain
Substitution of the carboxyl terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice
... the carboxyl-terminal domain of apo AI is associated with a de- crease of HDL levels due to increased HDL turnover and thus with a decrease of the cholesterol efflux ...a domain that ...
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The Carboxyl-Terminal Domain of RNA Polymerase II Is Phosphorylated by a Complex Containing cdk9 and Infected-Cell Protein 22 of Herpes Simplex Virus 1
... the carboxyl-terminal domain and some, as yet poorly defined, in the residual amino-terminal ...the carboxyl-terminal domain ap- pears to be required in a ...
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Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans
... the carboxyl-terminal domain (CTD) of hepadnavirus core protein and its state of phos- phorylation are critical for multiple steps in viral ...
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Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation
... Based on similarities in amino acid sequence between the AQP1 C-terminus, and subdomains of CNG channels and cGMP-PDE [16], we generated a set of mutations in the carboxyl terminal domain of AQP1. ...
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The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function.
... the carboxyl-terminal domain (CTD) of RNA poly- merase II (RNAP ...activation domain, can be coimmunoprecipitated with ...the carboxyl terminus of the protein, but analysis of proteins ...
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Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication
... IN carboxyl-terminal domain (CTD) (amino acids 212 to 288) by p300 using purified recombinant ...extreme carboxyl terminus of integrase, near the target site for ...
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Mutations in the Carboxyl-Terminal Domain of the Small Hepatitis B Virus Envelope Protein Impair the Assembly of Hepatitis Delta Virus Particles
... The carboxyl-terminal domain of the small (S) envelope protein of hepatitis B virus was subjected to mutagenesis to identify sequences important for the envelopment of the nucleocapsid during ...
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A nonsense mutation in the carboxyl terminal domain of type X collagen causes haploinsufficiency in schmid metaphyseal chondrodysplasia
... Over 25 mutations of COL10A1 , recently summarized by Wallis et al. (4), have been characterized in SMCD covering the gamut of amino acid substitutions, nonsense mutations, and deletions resulting in predicted protein ...
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Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
... extracellular domain and participate in cellular signaling with the carboxyl-terminal fragment that is hypothesized to be released following proteolytic cleavage ...Agrin) domain with the ...
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Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 Integrase
... Due to the relatively weak degree of sequence homology among retrovirus IN CTDs (a single invariant Trp at HIV-1 position 235), less is known about the precise roles of the CTD (residues 213 to 288) compared to the ...
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Functional Dissection of the Catalytic Carboxyl-Terminal Domain of Origin Recognition Complex Subunit 1 (PfORC1) of the Human Malaria Parasite Plasmodium falciparum
... The presence of the PIP motif in ORC1 homologs is an important finding (12). Here we show that the mutation in the PIP motif of ScORC1 leads to the loss of viability of yeast cells, suggesting its essential role in DNA ...
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Herpes Simplex Virus Type 1 Infection Leads to Loss of Serine-2 Phosphorylation on the Carboxyl-Terminal Domain of RNA Polymerase II
... RNAP IIA is responsible for 11323 Downloaded from http://jvi.asm.org/ on November 8, 2019 by guest Previous studies have shown that herpes simplex virus type 1 HSV-1 infection alters the[r] ...
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Phosphorylation in the carboxyl-terminal domain of the capsid protein of hepatitis B virus: evaluation with a monoclonal antibody.
... 2212 antibody bound to p21c from core particles derived from Dane particles or hepatocellular carcinoma tissues PLC/342 propagated in nude mice but did not bind to p21C from core particl[r] ...
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Roles of Carboxyl-Terminal and Farnesylated Residues in the Functions of the Large Hepatitis Delta Antigen
... the carboxyl-terminal region to HBsAg-L that are needed for the efficient interaction with ...intact carboxyl-terminal domain (with the exception of a very conservative ...
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Vojnic, Erika (2006): NMR solution structure of the Set2 SRI domain and preparation of RNA polymerase II complexes with the elongation factor Spt4-Spt5. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Trithorax] domain. During mRNA elongation, the SRI (Set2 Rpb1-interacting) domain of Set2 binds to the phosphorylated CTD (carboxyl-terminal domain) of RNAP ...SRI domain has ...
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Identification of a Lytic-Cycle Epstein-Barr Virus Gene Product That Can Regulate PKR Activation
... the carboxyl-terminal domain of Us11, a double-stranded RNA (dsRNA) binding protein encoded by HSV-1 that inhibits activation of the cellular PKR ...RXP domain significantly compromised all of ...
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Expression, characterisation and structural analysis of the putative slow voltage-dependent potassium channel minK
... In conclusion, synthetic peptides corresponding to functional domains provide an excellent model for studying membrane protein structure. However, if the functional domain is transmembranous, great care must be ...
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The Carboxyl-Terminal Region of Human Cytomegalovirus IE1491aa Contains an Acidic Domain That Plays a Regulatory Role and a Chromatin-Tethering Domain That Is Dispensable during Viral Replication
... mutants were calculated as a percentage of the plaques ob- tained with the full-length construct, differences were readily appreciated at MOIs of 0.0004, 0.002, and 0.01 (Fig. 3B). First, as expected, background ...
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Murine Type-C Virus Group-Specific Antigens: Interstrain Immunochemical, Biophysical, and Amino Acid Sequence Differences
... An intrastrain comparison of p30's with different isoelectric points also showed proline at the N-terminal, and preliminary experiments indicated leucine as carboxyl terminal; thus, in s[r] ...
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Phospholipid-Binding Protein Cts1 Controls Septation and Functions Coordinately with Calcineurin in Cryptococcus neoformans
... ner. C2 domains facilitate protein-protein interactions and signal transduction membrane association (6, 21, 40). FIG. 9. The C2 domain of Cts1 is necessary for growth at 37°C and binds ...
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