catechol-O-methyltransferase COMT gene
Catechol-O-Methyltransferase (COMT) Gene (Val158Met) and Brain-Derived Neurotropic Factor (BDNF) (Val66Met) Genes Polymorphism in Schizophrenia: A Case-Control Study
... of COMT Val158Met (G>A) and BDNF Val66Met (G>A) polymorphisms are presented in Table ...of COMT Val158Met (G>A) polymorphism were not significantly different between the patients with SCZ and HCs ...
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Original Article Association of catechol-O-methyltransferase val158Met polymorphism with postoperative analgesic opioid use
... Nowadays, Opioid such as morphine and Fentanyl has been widely used in postopera- tion pain control and showed well effects [1]. However, the consumption of opioid in postop- eration pain control varies widely among ...
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Depression and anxiety in relation to catechol O methyltransferase Val158Met genotype in the general population: The Nord Trøndelag Health Study (HUNT)
... The catechol-O-methyltransferase (COMT) gene located on chromosome ...the COMT enzyme's important role in the metabolism of cat- echolamines ...the COMT enzyme, and ...
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<em>COMT </em>Val158Met, but not <em>BDNF </em>Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study
... the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major ...
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The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus
... factors can be successfully controlled but the contribu- tion of decreasing hyperglycemia is lower than expected [41, 42]. Increment of 1% in HbA1c increased the risk of cardiovascular disease mortality by 53% in type 1 ...
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Original Article Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val 158 met and fibromyalgia
... indicating that the whole pooled results may be unbiased. Despite of the advantages men- tioned above, the current study has some inevi- table limitations that should be acknowledged. First, only published studies were ...
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No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol O methyltransferase gene The HUNT study
... the COMT gene has been thought to play a role in pain sensitivity in general, one might assume that it could be important in several different pain ...and COMT codon 158 ...
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Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment
... and COMT gene, which encode Mu and KAPPA opioid receptors, and Catechol-O-methyltransferase enzyme respectively, in a cohort of 129 Tunisian cancer pain patients under oral morphine ...
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Identifying molecular mechanisms of catechol o-methyltransferase activity and regulation
... structure without base pairs in the region of complementarity in 30-nt window length is defined as the energy required for target structure opening (Fig. 2A). Monte Carlo simulation and analysis of randomized sequences ...
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The association between headache and Val158Met polymorphism in the catechol–O–methyltransferase gene: the HUNT Study
... that COMT activity is lower in females than in males and that COMT activity may be under hormonal control [16, 17] is the reason for per- forming separate analyses for each ...
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Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al Ándalus project
... [7]. Catechol-O-methyltransferase (COMT), the most widely studied gene in fibromyalgia, is involved in degrading catecholamines and several other neurotransmitters and, therefore, in ...
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Effect of minor SNPs on enzymatic activity regulated by common human haplotypes of the catechol-O-methyltransferase gene
... The kinetic properties of S-COMT and MB-COMT vary greatly and are dependent upon the substrate. For example, MB-COMT is found within interstitial neurons postsynaptic to dopaminerigic neurons, where ...
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Association between Catechol-O-methyltransferase rs4680 (G > A) polymorphism and lung cancer risk
... of COMT Val158Met polymorphism with the risk of lung cancer in Chinese ...the gene–gene and gene–environment interactions that influence an individual lung cancer ...
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Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study
... One gene implicated in a number of mental health disorders including depression is catechol-O-methyltransferase (COMT), a gene which regulates catecholamine’s like dopamine, ...
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Roles of functional catechol O methyltransferase genotypes in Chinese patients with Parkinson’s disease
... the COMT gene, leading to the substitution of valine 158 with a methionine (Val158- Met) and resulting in low COMT enzyme activity, which is regarded as the L (low activity) allele, in contrast to ...
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Catechol-<em>O</em>-methyltransferase Val158Met genotype and the clinical responses to duloxetine treatment or plasma levels of 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in Japanese patients with major depressive disorder
... the COMT gene, particularly the Val158Met polymorphism, have been extensively investigated for associations with the clinical phenotypes of ...of COMT vari- ants on phenotypes relevant to ...with ...
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Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study
... The COMT gene contains several SNPs, some of which result in a marked clinical ...[6-8]. COMT activity is 3 to 4 times higher in Val homozygous compared to Met homozygous geno- type carriers ...
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Genetic contribution of catechol O methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study
... pain gene with age, gen- der and treatment to about 31% with addition of pain medication and anxiety and ...of COMT gene polymorphisms and it may be recommended to assess the influence of candidate ...
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Catechol O methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
... Six COMT SNPs (rs2097903, rs6269, rs4633, rs4818, rs4680, and rs165599) were genotyped from peripheral blood ...the COMT haplotype previously associated with high pain ...
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Linkage studies of catechol O methyltransferase (COMT) and dopamine beta hydroxylase (DBH) cDNA expression levels
... plasma COMT and DBH activities, and findings so far strongly suggest that the structural genes COMT and DBH encoding these proteins are the major quantitative trait loci for their respective plasma ...
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