Cell Acute Lymphoblastic Leukemia
Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
... ALL: Acute lymphoblastic leukemia; aMCB: Array-proven high-resolution multicolor banding; B-ALL: B cell acute lymphoblastic leukemia; BM: Bone marrow; Cdks: ...
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... established leukemia groups [19 – ...of leukemia cells was found in T-ALL pa- tients and MRD risk group classified by MRD levels at the end of induction and before consolidation therapy was identified to be ...
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Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation
... adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after ...
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Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
... AL: Acute leukemia; ALL: Acute lymphoblastic leukemia; ALWP: Acute Leukemia Working Party; AML: Acute myeloid leukemia; ATG: Antithymocyte globulin; BM: Bone ...
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... course, cell profile, and ...In acute lymphoblastic leukemia, it was reported that CD90+/CD110+ cells in acute lymphoblastic T-cell leu- kemia, and CD9-overexpressing ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cell mechanism of forcing T cells into senescence ...Treg cell accumulations in hematological malignancies such as acute myeloid leukemia (AML), acute lymphoblastic ...
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Stem cells in clinical practice: applications and warnings
... Stromal Cell; (ASC): Adult Stem Cell; (ALL): Acute Lymphoblastic Leukemia; (AML): Acute Myeloid Leukemia; (ASL): Amyotrophic Lateral Sclerosis; (AD): Autoimmune Diseases; ...
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A high complex karyotype involving eleven chromosomes including three novel chromosomal aberrations and monoallelic loss of TP53 in case of follicular lymphoma transformed into B-cell lymphoblastic leukemia
... ALL: Acute lymphoblastic leukemia; ALT: Alanine aminotransferase; aMCB: Array-proven multicolor banding; AST: Aspartate aminotransferase; B-ALL: B-acute lymphoblastic leukemia; ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... stem cell transplant- ation (allo-HSCT) has been the most successful immuno- therapy for AML over the past decade, especially with the advances made in using alternative donors ...with acute ...
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... Therapy-related acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...therapy-related acute myeloid ...
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<p>Infectious complications in children with malignant bone tumors: a multicenter nationwide study</p>
... ALL, acute lymphoblastic leukemia; AML, acute myelogen- ous leukemia; AmpC, cephalosporinase AmpC; auto-HCT, autologous hematopoietic cell transplantation; BSI, blood- stream ...
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The Philadelphia chromosome in leukemogenesis
... myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic ...distinct leukemia phenotype, which predicts both response to therapy ...
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Protein kinase inhibitors for acute leukemia
... Acute leukemia is subdivided into acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL) [1, ...all acute leukemias in adults, and the cure rates ...
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Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... ALL: acUte lymphoblastic leukemia; AML: Acute myeloid leukemia; BCL-6: B-cell lymphoma 6 protein; Bmi1: B cell-specific Moloney murine leukemia virus integration ...
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Drugging the unfolded protein response in acute leukemias
... Upon activation, PERK phosphorylates eukaryotic transla- tion initiation factor 2 subunit alpha translation initiation factor (eIF2α) at serine 51 (S51) [9], thereby attenuating global protein synthesis to reduce the ...
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Childhood leukemia: central nervous system abnormalities during and after treatment
... Bacterial or fungal infections associated with neutropenia are common in patients with newly diagnosed or recurrent acute leukemia (32, 33). Three of our five patients with CNS infections had persistent ...
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VITAMIN D STATUS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
... 8-Veerman AJ, Kamps WA, van den Berg H, van den Berg E, Bökkerink JP, Bruin MC et al. Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood ...
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Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
... Different mechanisms have been proposed to explain the etiology of DCL. Extrinsic factors focus on chemo- therapy and radiation-induced stromal abnormalities [6,8,21]. Intrinsic factors may be related to the donor, such ...
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WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
... in acute leukemia still remains unclear, and the role of WT1 in the process of leukemogenesis is not well ...of leukemia cases, the abnormality inWT1 expression is only of a quantitative ...
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BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects
... In lymphoma, preclinical data suggest that BET inhibitors have the potential to synergize with several targeted agents presently used in practice. In one study, the BET inhibitor OTX015 was examined as a single agent, or ...
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