cell-cycle regulators
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen
... RNAi library vector inserts (integrated into the rDNA spacer region of the genome) were PCR-amplified from genomic DNA of clones, sequenced and analysed by BLAST analysis at GeneDB http://www.genedb.org/ ...
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Herpesvirus saimiri MicroRNAs Preferentially Target Host Cell Cycle Regulators
... in cell cycle regulation are en- riched among the top miR-HSUR targets ...target cell cycle regulators. This is consistent with the T-cell oncogenic phenotype of HVS ...
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Differential expression of cell cycle regulators in CDK5- dependent medullary thyroid carcinoma tumorigenesis
... encoding cell cycle regulators such as CDKs, cyclins and CDK inhibitors, are significantly upregulated in malignant mouse tumors in a CDK5-dependent ...these cell cycle ...
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Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
... for cell cycle regulators, which is not unexpected, given the critical role of prolifer- ation and differentiation in ...the cell cycle proteins involved in haematopoiesis almost ...
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Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators
... research efforts is promising, as approaches that are sufficiently sensi- tive to map and (importantly) quantify endogenous redox PTMs and changes at the residue level are absolutely crucial for analysing subtle changes ...
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A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival
... in cell numbers as compared to DMSO treated controls, of each cell line were compared and 34 compounds were found to be effective in all three cell lines ...of cell cycle ...
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Altered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients
... impedes cell cycle in G1/S checkpoint until DNA repair ...infected cell lines, Tax expression hinders the function of p53 and promotes oncogenesis in host cells ...in cell cycle ...
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Characterization of genetic interactions between cell cycle regulators and armadillo in Drosophila melanogaster
... There are at least two drawbacks to the phenotypic analyses described above. First, as the somatic clones were unmarked, subtle defects may have been missed or gone undetected because of the elimination of l(3)neo40^ ...
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Cell Cycle Regulators Interact with Pathways That Modulate Microtubule Stability in Saccharomyces cerevisiae
... specific cell cy- cle ...MluI cell cycle box [MCB]-binding factor) and the SBF complex (SBF for Swi4/6 cell cycle box [SCB]-binding factor), and these in turn promote the transcription ...
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Inhibitory effect of Au@Pt-NSs on proliferation, migration, and invasion of EJ bladder carcinoma cells: involvement of cell cycle regulators, signaling pathways, and transcription factor-mediated MMP-9 expression
... the cell cycle is limited, the kinase activities of CDKs are inhibited by cyclin-dependent kinase inhibitors (CKIs), including p21WAF1, p27KIP1, and ...Among regulators of the G1 phase of EJ cells, ...
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Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators
... Global redox proteomics studies in plants and other photosynthetic organisms: S-Nitrosylation * = endogenous level detection Biological system Methodology Quantification and site identif[r] ...
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Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators
... Methodology General comments on type approach Reversible oxidation -SOx Indirect: tag switch - lysates only - indirect method & multistep Indirect: detect - cells possible absence of lab[r] ...
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Notch1 signaling regulates the proliferation and self-renewal of human dental follicle cells by modulating the G1/S phase transition and telomerase activity
... proliferation, cell cycle distribution and the expression of cell cycle regulators were investigated through various molecular technologies, including plasmid construction, retrovirus ...
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When cell cycle meets development
... between cell proliferation and differentiation: (1) cell cycle exit is not necessary to initiate differentiation; (2) instead, differentiation can be initiated by slowing of the cell ...
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In Vivo Analysis of the Domains of Yeast Rvs167p Suggests Rvs167p Function Is Mediated Through Multiple Protein Interactions
... during cell division in the yeast Saccharomyces cerevisiae are controlled by cell- cycle ...the cell cycle regulator Pcl-Pho85p kinase and the actin ...
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Statin induced anti proliferative effects via cyclin D1 and p27 in a window of opportunity breast cancer trial
... the cell cycle regulators cyclin D1 and p27, as has been addressed in this ...to cell membranes and perform their normal functions, a process known as pro- tein prenylation ...
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MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
... the cell cycle regulators modulated by the MYC-repressed MYCLo-4, -5 and -6, we profiled the expression of 183 cell cycle regulator genes using the nCounter Virtual Cell ...
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PubMedCentral-PMC5344651.pdf
... exit cell cycle shortly after birth and retain limited proliferative potential, thereby rendering the adult hearts incapable to regenerate after myocardial insults, and consequently develop heart failure ...
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Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Helen M. Coley 1, Eleftheria Hatzimichael2 , Sarah Blagden 3, Iain McNeish4 , Alastair Thompson 5, Tim Crook5 and Nelofer Syed 6
... resistant cell population is ...non-small cell and small cell lung cancer and ...key cell cycle regulators would increase with ongoing exposure to cytotoxic drugs and then ...
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β1 integrin is a crucial regulator of pancreatic β cell expansion
... of cell-matrix recognition and might contribute/transduce pro-differentiative signaling cues allowing for the development and functional maturation of ...stationary cell adhesion to motility and invasion, ...
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