Changes in the transcriptome and proteome
Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome
... Biological systems are organized in scale-free networks [22] . The promise of systems biology is to characterize these networks and to finally predict their behavior. Despite the comprehensive coverage obtained by ...
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Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability
... ‘Venn Diagram’ tab shows a simple Venn diagram to illus- trate the numbers of differentially expressed proteins under each condition. Table S3. 2D-gel analysis of proteins from cells grown at all steady-states from 25% ...
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Functional mapping of the zebrafish early embryo proteome and transcriptome
... deep proteome map of a selected 774 stage of early embryonic development in zebra ...embryo proteome. In addition, we also 777 performed transcriptome mining by RNA-seq to provide an 778 informative ...
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Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast
... Here we applied genome-wide translational profiling, combined with mRNA profiling, in fission yeast cells exposed to oxidative stress, heat shock, or DNA damage. Most stress-response genes were regulated in a concor- ...
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Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
... study changes in the transcriptome profile, specifically identifying the mRNA tran- scripts that undergo regulation, therefore highlighting the poten- tial molecular pathways underpinning a certain trait or ...
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Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines
... number changes, this second filter afforded significant improvements, reducing the number of putative genes contributing to rapid proliferative state to around a few dozen genes per cell line, all of which ...
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Transcriptome changes in age-related macular degeneration
... While the last decade has seen great progress in under- standing the pathophysiology of AMD, the molecular changes that occur in eyes with AMD are still poorly understood. The study of AMD is complicated by the ...
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Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.
... Alternatively, it can point to alternative biomarkers in an accessible biological compartment, which can replace biomarkers that are dif- ficult to obtain or expensive to measure. Recent technological advances in science ...
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Investigation of the adaptation of Lactococcus lactis to isoleucine starvation integrating dynamic transcriptome and proteome information
... In order to confirm transcriptomic results RT-PCR mea- surements were performed in exponential phase and after 1.34 h of isoleucine starvation. Nine genes were chosen so as to cover a wide range of functional cate- ...
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The coupling of transcriptome and proteome adaptation during development and heat stress response of tomato pollen.
... pollen proteome along the course of development as well as the analysis of protein level changes in developing pollen under elevated ...the proteome as it provides direct information about enzym- ...
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Transcriptome and proteome quantification of a tumor model provides novel insights into post‐transcriptional gene regulation
... Results: Here, we employ deep sequencing and the isobaric tag for relative and absolute quantification (iTRAQ) technology to determine transcript and protein expression changes of a Drosophila brain tumor model at ...
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Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson’s disease
... our transcriptome analysis did not identify any differentially expressed genes in the SVZ between control and PD patients, our proteome analysis revealed several proteins that were differentially expressed ...
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Proteome changes of Caenorhabditis elegans upon a Staphylococcus aureus infection
... the transcriptome level is not the best option, because the correlation between the amount of mRNA and the amount of protein or certainly the amount of (in)activated protein ...
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Changes in the proteome of the problem weed blackgrass correlating with multiple-herbicide resistance
... resistance proteome, total soluble protein extracts from HS Rothamsted and NTSR Peldon and Oxford populations were separated on large format two-dimensional electrophoresis and differen- tially quantified using ...
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Transcriptome, proteome and draft genome of Euglena gracilis
... To address this question, we employed a second ap- proach, in which we performed exhaustive analysis to es- tablish phylogenetic ancestry of individual proteins from the predicted Euglena proteome by generating ...
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Parallel deep transcriptome and proteome analysis of zebrafish larvae
... Our pipeline approach can be used by other groups to get a rapid insight into results obtained from dif- ferent technology platforms. The results show that comparison of levels of RNA deep sequencing and proteomics have ...
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Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma
... tissue transcriptome has advantages over the tissue proteome for this purpose because a greater proportion of the genome is typically covered, and upregulated secreted proteins may have elevated mRNA levels ...
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Critical controllability in proteome-wide protein interaction network integrating transcriptome
... Masayuki Ishitsuka 1 , Tatsuya Akutsu 2 & Jose C. Nacher 1 Recently, the number of essential gene entries has considerably increased. However, little is known about the relationships between essential genes and their ...
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Age-associated changes in human tear proteome
... Although various age-related diseases have been stud- ied using tear fluid proteomics [21–23], any wider mass spectrometry discovery studies have not been performed on the tear fluid proteome changes during ...
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Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing.
... OPC proteome is that neonatal OPCs differ in approximately 50% of the proteome from their young and aged ...OPC proteome is not complete in our samples: low abundance proteins such as transcription ...
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