chimeric antigen receptors
Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... With breakthroughs in synthetic biology, improved cell culture techniques and advanced genetic engineering, it has now become possible to generate bi-specific primary human T cells with desired specificities. One mode of ...
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T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells
... expressing chimeric antigen receptors (CAR) showed re- markable curative effects in multiple tumor types, espe- cially, in the case of hematologic malignancies ...extracellular antigen-binding ...
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Engineering Chimeric Antigen Receptors For Durable Control Over Hiv-1 Replication
... cell receptors (TCRs) or chimeric antigen receptors (CARs) (4, ...extracellular antigen binding domain fused to intracellular T cell activation domains ...synthetic receptors can ...
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HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies
... of chimeric antigen receptors (CARs) based on single-chain antibodies for gene immunotherapy of cancers is increasing due to promising recent results, the earliest CAR therapeutic trials were done ...
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A CD19/Fc fusion protein for detection of anti CD19 chimeric antigen receptors
... Background: Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating ...
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Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells
... [2-5]. Chimeric antigen receptors (CARs) have also been investigated as an alternative way to redirect T cells to recognize and des- troy tumor ...effect antigen recognition in a manner that ...
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Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors
... CAR hi but not CAR lo cells exhibit robust T-cell functions Given their differences in CD25 expression, we hypothe- sized that the CAR hi subpopulation is productively acti- vated while CAR lo cells remain inactive or ...
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... human HER2, as well as SKBR3 and HCC1954, human breast carcinomas which naturally overexpress HER2. HER2-negative cell lines included D2F2, a murine breast carcinoma (the parental line of D2F2/E2), and LOX-IMVI, a human ...
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Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
... An established method of enriching Ag-specific Tregs is through repetitive stimulation in vitro. The feasibility of this approach has been successfully demonstrated in the context of transplantation (3), leading to ...
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A phase I clinical trial of adoptive T cell therapy using IL 12 secreting MUC 16ecto directed chimeric antigen receptors for recurrent ovarian cancer
... This clinical trial is unique in numerous other aspects compared to previous trials, mainly due to the incorpor- ation of CAR T cells that secrete IL-12, allowing for the favorable modulation of the tumor ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... intermediate- or high-risk factors associated with AML [6]. In addition, allogeneic hematopoietic stem cell transplant- ation (allo-HSCT) has been the most successful immuno- therapy for AML over the past decade, ...
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Chimeric antigen receptors: unleashing a new age of anti-cancer therapy
... Novel developments and current clinical trials To circumvent the challenges and present limita- tions of CAR T cell monotherapy, scientists have sug- gested the use of combinational therapies to enhance CAR efficacy. For ...
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Treating Cancer With Engineered T Cell Therapies: Murine and Canine Models of Safety and Efficacy
... Chimeric antigen receptors (CARs) combine MHC-independent recognition of a target antigen with potent T cell activation signals, and can be used to re-direct T cell specificity (Gross et ...
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Chimeric antigen receptor T cell therapies for multiple myeloma
... mature antigen; BsAb: Bispecific antibody; CARs: Chimeric antigen receptors; CAR-T: Chimeric antigen receptor-modified T cells; CD: Cluster of differentiation; CLL: Chronic ...
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CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA A REVIEW
... parts; antigen recognition region, spacer, and signal peptide ...The antigen recognition domain is scFv with a basic ectodomain and more exotic recognition ...tumor antigen will bind in the ...
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A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer
... using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role of other CAR-modified leukocytes is not well ...including antigen specific cytotoxicity and ...
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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
... Activin A regulates multiple biological functions such as hormonal homeostasis, inflammation, and bone homeo- stasis by stimulating osteoclastogenesis and inhibiting the formation of osteoblasts. Activin A is produced by ...
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Multicomponent Chimeric Antigen for Serodiagnosis of Canine Visceral Leishmaniasis
... The expression and recovery yields for each of the interme- diate products are shown in Fig. 3A and B. As expected, after each addition step, the size of the expression products in- creased until there was a molecular ...
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Cancer biomarkers for targeted therapy
... Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bispecific T ...
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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
... recognizing receptors, such as killer cell immunoglobulin-like receptors (KIR) and lectin-like NKG2A heterodimers, results in inhibitory signals ...cytotoxic receptors (NCR) NKp30 [45], NKp44 [46], ...
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