Classical complement pathway
C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy
... the classical complement pathway at the initiating stage using the anti-C1q monoclonal antibody M1 [28] similarly at- tenuates dysfunction and ...inhibit classical complement path- way ...
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Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals
... 10 mg of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees C. C1, C4, and C3 depletion of 52, 68, and 46% were typical of classical pathway activation. C1 ...
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Interaction of desialated guinea pig erythrocytes with the classical and alternative pathways of guinea pig complement in vivo and in vitro
... the classical complement pathway component C4 (C4D-GP), which activate complement only via the alternative ...that complement activation is essential for clearance of desialated E and ...
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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration
... the classical path- way in AMD, including genetic polymorphisms [17] and an abundance of autoantibodies associated with AMD ...the classical complement pathway, has also been implicated in a ...
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Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing
... potent classical complement pathway-mediated host defenses including op- sonization and anaphylatoxin production [ 24 ...of classical complement pathway activation in the host is ...
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Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
... of classical (C1q and C4) complement pathway have not been detected associated with thiofla- vine positive ...the classical complement pathway) on the plaques of the 3xTg or ...
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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
... The key finding in the present study is that early synaptic and dendritic atrophy were prevented through inhibition of the C1 complex, the initiating complex of the classical complement pathway. D2. ...
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Interactions of the Classical and Alternate Complement Pathway with Endotoxin Lipopolysaccharide EFFECT ON PLATELETS AND BLOOD COAGULATION
... alternate complement pathway in C4D guinea pigs, as evidenced by the fall in C3-9 ...the classical complement pathway was an absolute requirement for the development of ...
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<p>Cold agglutinin disease: current challenges and future prospects</p>
... a complement-dependent, classical pathway- mediated immune hemolytic disease, accounting for 15 – 25% of autoimmune hemolytic anemia, and at the same time, a distinct clonal B-cell ...
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Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway
... The complement system is an extremely potent inflam- matory cascade composed of more than 30 plasma and cell membrane proteins that plays major roles in innate immune defense as well as many inflammatory diseases ...
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Species Specificity of Vaccinia Virus Complement Control Protein for the Bovine Classical Pathway Is Governed Primarily by Direct Interaction of Its Acidic Residues with Factor I
... VCP displays selectivity for inhibition of the bovine classical complement pathway. Successful establishment of viral infection in the host is contingent upon the ability of the virus to subvert the ...
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Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes
... C-NHEJ pathway is often considered more error-prone than the HR pathway, this view has been challenged recently by emerging evidence that the latter can often be erroneous as well, especially in large and ...
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Complement regulator CD46: genetic variants and disease associations
... In contrast, atypical HUS (aHUS) is a more severe, non-diarrheal type that results from alternative pathway over-reaction on endothelial cells, particularly in the kid- ney. Penetrance is ~50 % with a relapsing ...
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Lipoarabinomannan-Induced Cell Signaling Involves Ceramide and Mitogen-Activated Protein Kinase
... the classical PKC signaling pathway is inhibited in cells treated with LAM, we tried to study a signal transduction pathway other than the classical ...signaling pathway (19, 28, 44). ...
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Involvement of Antilipoarabinomannan Antibodies in Classical Complement Activation in Tuberculosis
... on complement activation-dependent epitopes in C3 and TCC to determine the extent of complement activation induced by BCG in dif- ferent ...soluble complement activation products and an indirect ...
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Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans
... Following C3 activation, the metastable C3b molecule must quickly bind to an electron-donating –OH group through the thioester bond; failure to do so results in hydrolysis of the thioes- ter, and the C3b molecule remains ...
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Inhibition of Complement as a Therapeutic Approach in Inflammatory Central Nervous System (CNS) Disease
... inhibiting the activation of the classical pathway, thus its therapeutic value in CNS disease appli- cations, where the classical pathway is often ac- tivated, is questionable.. An addit[r] ...
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Complement is activated in progressive multiple sclerosis cortical grey matter lesions
... S2. Complement recognition fragment, activation products and regulator expression in MS, non-MS inflammatory controls (IC) and non- neurological control (Ctrl) grey ...anti- complement immunostaining seen ...
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Paths reunited: initiation of the classical and lectin pathways of complement activation
... A critical facet of the complement cascade is that activation is only triggered when C1 complexes bind to an activating surface. There are several factors intrinsic to C1 that combine to prevent inappropriate ...
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Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum
... the complement plays a major role in the immune recognition of nanoparticles and pathogens ...by complement receptors CR3 (also known as CD11b/CD18 or Mac-1), complement receptor CR4 (CD11c/CD18), ...
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