cold ischemia
Early innate immune events induced by prolonged cold ischemia exacerbate allograft vasculopathy
... Prolonged cold ischemia leads to earlier lesion formation Earlier studies conducted in the absence of CNI immu- nosuppression provide evidence that prolonged CI exacerbates AV, resulting in larger ...
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Original Article Hsp27 reduces cold ischemia-reperfusion injury in heart transplantation through regulation of NF-κB and PUMA signaling
... pAAV-Hsp27 was used to infect the grafted heart as previously described [34]. Heterotypic cardiac transplantation was performed in a syngeneic recipient as previously described [15]. The donor hearts were excised and ...
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The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury
... Experimental design and operative technique. Inbred male Lewis (LEW) rats of 250–300 g (Harlan Sprague Dawley Inc., Indianapolis, IN) were used. A cold ischemia/reperfusion injury model of renal injury has ...
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Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation
... All of the transplant procedures in this study were per- formed under a stereo microscope. All surgical procedures were performed with clean but nonsterile instruments, and antibiotics were not used. The body weights of ...
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Upregulation of heme oxygenase 1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury
... Ischemia/reperfusion is markedly increased in steatot- ic livers compared with normal livers, and reactive oxy- gen species have been shown to contribute, at least in part, to this event (31). Moreover, the ...
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Original Article The effects of cold-heat liver ischemia-reperfusion injury on HSP60 expression and ATPase activity in rats
... of ischemia, it can be divided into heat ischemia injury and cold ischemia ...the cold IRI is more common in liver trans- plantation ...by ischemia-induced cell hypoxia and ...
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Protective Benefits of Hydrogen Sulfide Treatment During Renal Transplantation
... prolonged cold IRI on donor ...increasing cold ischemia time remains an indicator of DGF and worse graft function and survival, particularly in “marginal” donor organs, we sought to explore ...
214
Factors determining short term graft function in Renal Transplant Recipients.
... In a study at Netherlands by Henk Brom et al, several risk factors for DGF were identified, of which a low recipient pre-transplant mean arterial blood pressure, the transplantation of kidneys from female donors to male ...
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Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)
... comorbidity, cold ischemia time (CIT), human leukocyte antigen (HLA) mismatches, prior dialysis modality, prior KT, time on dialysis prior to transplant as well as other usual risk variables such as serum ...
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Improved renal ischemia tolerance in females influences kidney transplantation outcomes
... Our effort builds on this earlier work by focusing on the ele- ments of sex effects that are relevant and modifiable in a time frame compatible with clinical transplantation and by demon- strating that the murine ...
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Serum neutrophil gelatinase-associated lipocalin and recovery of kidney graft function after transplantation
... AKI: Acute kidney injury; AUC: Area under the curve; CIT: Cold ischemia time; DGF: Delayed graft function; EGF: Early graft function; eGFR: Estimated glomerular filtration rate; NGAL: Ne[r] ...
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Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation
... CIT: Cold ischemia time; DBD: Donation after brain death; DCD: Donation after cardiac death; DGF: Delayed graft function; eGFR: Estimated glomerular filtration rate; GL: Graft loss; HD: Hemodialysis; HLA: ...
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Everolimus in kidney transplantation
... In accordance with these data, a study of 139 patients receiving kidneys at high risk for delayed graft function (donor age. 55 years, cold ischemia time. 24 hours, or retra[r] ...
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Nitric oxide metabolism in ischaemic preconditioning of the liver
... Keywords: I, ischemia; R, reperfusion; *, cold ischemia; t , increased; decreased; LFT’s, liver function tests; NOS, nitric oxide synthase;.. cNOS, constitutive nitric oxide synthas[r] ...
217
The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung
... to ischemia- reperfusion injury ...with cold ischemia time, suggesting that presumed cell necrosis and apoptosis cannot on their own explain the high abundance of cytokines in our ...extended ...
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Key words
... “cold” ischemia peri- od [2] may suggest that in this phase there is also an imbalance between the levels of antioxidants and ...“cold” ischemia on SOD and CAT ...
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Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation
... in cold-storage conditions led to increased quality of the cadaveric kidney transplants although after transplantation a substantial percentage of grafts still do not function ...prolonged ...
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Hartkorn, Andreas (2008): Different approaches to influence the ischemia/reperfusion injury of the liver. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... or cold ischemia followed by reperfusion, with the hormone atrial natriuretic peptide (ANP) reduced tissue damage and increased liver function, due to direct impact on several mediators of IR (NF- κ B, ...
132
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
... Patient identification information* Physician identification* Date of service* Specimen site and type* Specimen identification case and block number* Fixative Cold ischemia time time bet[r] ...
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Role of warm ischemia on innate and adaptive responses in a preclinical renal auto transplanted porcine model
... P-selectin was temporary expressed in cold ischemia groups at H3 and D3 supporting an early and transient endothelial activation after cold ischemia (Figure 2a). Toll-like receptors (TLRs) and ...
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