Complement control protein
The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection
... that complement activation en- hances T cell and antibody (Ab) responses during viral infection, it is unknown whether inhibition of com- plement by pathogens alters these ...modulates complement activation ...
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Molecular Characterization of the Rhesus Rhadinovirus (RRV) ORF4 Gene and the RRV Complement Control Protein It Encodes
... modulate complement activation indicates that this component of the immune system has significant antiviral ...(KSHV) complement control protein (KCP), which inhibits progression of the ...
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein
... human complement regulators named vaccinia virus complement control protein ...contiguous complement control protein (CCP) ...the protein is required for VCP’s ...
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Glycosylated and Nonglycosylated Complement Control Protein of the Lister Strain of Vaccinia Virus
... virus complement control protein (VCP) is a secreted viral protein that binds the C3b and C4b complement compo- nents and inhibits the classic and alternative complement ...C4b ...
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Dissection of Functional Sites in Herpesvirus Saimiri Complement Control Protein Homolog
... human complement regulators named complement control protein ho- molog ...inactivates complement by support- ing factor I-mediated inactivation of complement proteins C3b and C4b ...
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Function of Bovine CD46 as a Cellular Receptor for Bovine Viral Diarrhea Virus Is Determined by Complement Control Protein 1
... of complement activation family of proteins (RCA), which consist of various numbers of repetitive modules of 60 amino acids including two intramodu- lar disulfide bridges, which are termed short consensus repeat ...
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Dissecting the Regions of Virion-Associated Kaposi's Sarcoma-Associated Herpesvirus Complement Control Protein Required for Complement Regulation and Cell Binding
... cycle protein called KSHV complement control protein (KCP) that inhibits activation of the complement ...These complement regulatory activities require the short consensus repeat ...
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Cell Surface Expression of the Vaccinia Virus Complement Control Protein Is Mediated by Interaction with the Viral A56 Protein and Protects Infected Cells from Complement Attack
... the control of a VACV synthetic strong early-late promoter (7) were then inserted into the thymidine kinase locus, and recombinant viruses were isolated by selection with bromodeoxyuridine and screening with ...
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Mapping of Functional Domains in Herpesvirus Saimiri Complement Control Protein Homolog: Complement Control Protein Domain 2 Is the Smallest Structural Unit Displaying Cofactor and Decay-Accelerating Activities
... To identify the domains required for cofactor activities of sCCPH against C3b and C4b, we utilized a fluid phase assay wherein C3b or C4b was incubated with each of the deletion mutants and factor I, and inactivation of ...
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Identification of Functional Domains in Kaposica, the Complement Control Protein Homolog of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)
... The mutant proteins were expressed and concentrated from the culture supernatants by ultrafiltration followed by ammo- nium sulfate precipitation (80%) and purified as given below. Kaposica mutants 1–2 and 1–3 were ...
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The Vaccinia Virus A56/Vcp Complex: Mechanism of Formation and Implications for Virulence
... vaccinia complement control protein (VCP) and A56, the vaccinia ...the complement cascade; A56 was known to bind another viral protein, ...A56 protein that cannot bind ...
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Poxvirus Complement Control Proteins Are Expressed on the Cell Surface through an Intermolecular Disulfide Bridge with the Viral A56 Protein
... virus complement control protein (VCP), which is both secreted from and expressed on the surface of infected cells (9, 14, 16, ...the complement system, a series of soluble proteins that is an ...
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Whole-exome sequencing associates novel CSMD1 gene mutations with familial Parkinson disease
... Genetic results. WES approaches were performed in 3 different family members (cases A1, A2, and B1) belonging to 2 PD families (families A and B) and 1 iso- lated familial case. Between 96.38% (case A2) and 93.56% (case ...
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SERUM LEVELS OF C-REACTIVE PROTEIN, COMPLEMENT 3 AND COMPLEMENT 4 IN IRAQI DIABETIC PATIENTS ON METFORMIN THERAPY
... metformin control and CRP ...glycemic control has promising effect in preventing or delaying cardiovascular complications mainly via alleviation of inflammatory process reflected by a reduction of CRP ...
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Transcriptional Control of Complement Activation in an Exercise Model of Chronic Fatigue Syndrome
... transcriptional control that may con- tribute to the increased C4a in CFS subjects after ...ribosomal protein, large, P0 (RPLP0) and phosphoglycerate kinase 1 ...in control subjects (PPIB, P = ...
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Monocyte surface expression of Fcγ receptor RI (CD64), a biomarker reflecting type I interferon levels in systemic lupus erythematosus
... The specificity of CD64 fluorescence intensity for IFN-I levels is suggested by several lines of evidence. CD64 expression was enhanced in a dose-dependent manner by IFN-α and was blocked by the viral IFN-I inhibitor ...
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Complement Regulation by Kaposi's Sarcoma-Associated Herpesvirus ORF4 Protein
... Analysis of KCP expressed in transfected cells. The entire ORF4 coding region, from initiation codon to stop codon, was cloned into a eukaryotic expression vector containing the elon- gation factor 1␣ promoter and the ...
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Rethinking Cooperative Rationalization: Introspective Extraction and Complement Control
... The key motivation for our work arises from the potential failures of cooperative selection. Since the generator typically has no direct access to the outcome it aims to justify, the learning process may converge to a ...
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Comparison of the counter immunoelectrophoresis technique with the Reiter protein and three other serological tests as a first line test for syphilis
... The counter-immunoelectrophoresis technique with the Reiter protein RPCIE was compared with two complement fixation tests Kolmer and RPCF and a flocculation test VDRL in sensitivity and [r] ...
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Review on Quality Characteristics of Complementary Food and Look for Policy Gap in Case of Ethiopia
... protein-energy, vitamins and minerals. Formulated complementary food must be soft, acceptable and contain the essential nutrients in the appropriate proportion to supply the babies need for growth and development ...
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