complement dependent cytotoxicity
Low pH impairs complement-dependent cytotoxicity against IgG-coated target cells
... modulate complement- dependent cytotoxicity (CDC) against IgG-coated ...a complement source, we found that extracellular pH values of ...the complement system induced by the alternative ...
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Utilization of Complement-Dependent Cytotoxicity To Measure Low Levels of Antibodies: Application to Nonstructural Protein 1 in a Model of Japanese Encephalitis Virus
... Antibody-mediated complement-dependent cytotoxicity (CDC) frequently has been used for specific cell depletion ...on complement activation triggered by a specific antibody binding to the ...
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Transplant outcomes in positive complement-dependent cytotoxicity- versus flow cytometry-crossmatch kidney transplant recipients after successful desensitization: a retrospective study
... on complement-dependent cytotoxicity (CDC) crossmatch for identifying and characterizing anti-HLA antibody, such as the single-antigen assay and the C1q assay, have recently been developed and used ...
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Sialylation of IgG Fc domain impairs complement dependent cytotoxicity
... IgG Fc sialylation impairs complement-dependent cytotoxicity. Rituximab (RTX) is a chimeric mouse-human IgG1 monoclonal antibody that targets the CD20 antigen, which is expressed on B lymphocytes. ...
12
Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica
... activated complement [7, 8], and acti- vated complement proteins are elevated in the serum and cerebrospinal fluid (CSF) of NMO patients [9, ...human complement proteins [13], introduced into ro- ...
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Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors
... Results: Characterization of BTZ-resistant JY/BTZ cells compared to parental JY/WT cells revealed the following features: (a) 10 – 12 fold resistance to BTZ associated with the acquisiti[r] ...
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Polyfunctional anti human epidermal growth factor receptor 3 (anti HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers
... cellular cytotoxicity; Ad-HER3: Adenovirus encoding full length human HER3; APC: Allophycocyanin; BSA: Bovine serum albumin; CDC: Complement-dependent cytotoxicity; CMV: Cytomegalovirus; CNS: ...
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Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus
... found complement-dependent cytotoxic antibodies in the serum of 8 of 24 patients with insulin-dependent diabetes mellitus using a 51Cr cytotoxicity assay with monolayers of cloned rat islet ...
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Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination
... both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) in an Fc-dependent manner [30–34], in vitro studies have demonstrated MOG ...
14
Monoclonal antibodies targeting cancer: 'magic bullets' or just the trigger?
... and complement-dependent cytotoxicity (CDC) have been demonstrated in vitro, although the main determinants of its clinical efficacy have not been ...FcγRIII- dependent host component of ...
5
Targeting CLL-1 for acute myeloid leukemia therapy
... cell cytotoxicity (ADCC) and complement-dependent cytotoxicity ...CDC cytotoxicity against AML cell lines and de- layed the progress of HL-60 cells in vivo ...
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A novel autoantibody against fibronectin leucine rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus
... cell-mediated cytotoxicity; AECAs: anti- endothelial cell antibodies; APC: allophycocyanin; AUs: arbitrary units; CDC: complement-dependent cytotoxicity; DMEM: Dulbecco modified Eagle medium; ...
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Multiple sclerosis: Immunopathology and treatment update
... ADCC, antibody-dependent cellular cytotoxicity; CDC, complement-dependent cytotoxicity; DC, dendritic cells; EKAY, single amino acid code for L -glutamic acid, lysine, alanine, tyrosine;[r] ...
27
Investigating remission and relapse in type 1 diabetes. Immune correlates of clinical outcome in beta-cell replacement therapies
... Significant variation for the HLA staining was noted when optimizing HLA specific staining in different organs. This was especially relevant since HLA expression was studied on transplanted pancreatic endocrine tissue ...
90
Antibody dependent cell mediated cytotoxicity in selected autoimmune diseases
... incubation. Sera from patients with systemic lupus erythematosus inhibited antibody- dependent cell-mediated cytotoxic activity of normal lymphocytes. The inhibitory activity was studied by specific ...
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In-Vitro Anti-Proliferative Effects of Ethanolic Extract of Vanilla Planifolia Leaf Extract Against A431 Human Epidermoid Carcinoma Cells
... Cytotoxicity of vanilla leaf extract on A431 cells Vanilla leaf extract has shown cytotoxicity to cancer cells in a dose dependent manner. With increase in dose of the extract from 7.8µg/ml, 15.6, ...
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Membrane bound hemagglutinin mediates antibody and complement dependent lysis of influenza virus treated human platelets in autologous serum
... Influenza A virus-treated human platelets were lyzed in autologous serum. Lysis required the presence of antibody and occurred predominantly through activation of the classical complement pathway. Binding of the ...
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Complement dependent histaminase release from human granulocytes
... neutrophils. In contrast, phagocytosis of "opsonized" particles was required for noncytotoxic release of histaminase and arylsulfatase from eosinophils; other proteins, as well as C3b, were able to opsonize ...
9
CD4- and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
... While the possibility of time-dependent differential susceptibility to ADCC is a topic that warrants investigation, it is important to note that in vitro measurements of anti-HIV-1 ADCC are complicated due to ...
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Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
... Background: Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple ...
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