Conformational dynamics
Isolate-Specific Differences in the Conformational Dynamics and Antigenicity of HIV-1 gp120
... In summary, significant isolate-specific differences in stability were observed throughout gp120. Most notably, peptides map- ping to the gp120 inner domain were consistently more disor- dered in 1157ip than in matched ...
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New Methods To Assess Protein Folding And Conformational Dynamics
... and conformational energy landscape depends on a large number of molecular degrees of freedom and ...associated conformational transitions can take place over a wide range of ...folding dynamics and ...
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Modeling conformational dynamics of cisplatin and oxaliplatin adducts with DNA
... When comparing CP-DNA to OX-DNA, some considerable differences were observed. For base-base helical parameters, noticeable differences were observed for propeller twist for the G*6·C19 and G*7·C18 base pairs and buckle ...
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The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
... A great strength of IM-MS is the ability to characterise and compare dynamic changes in analyte structure, which has previously been extremely difficult for most biological samples. At present IM- MS studies often ...
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Infrared Measurements of Protein Conformational Dynamics
... We first probed 10b-azob at 1630 cm -1 , where helical content is known to absorb. If indeed we are populating more helical conformations upon irradiation with 355 nm light in this system, as observed in our steady state ...
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Conformational dynamics of a seven transmembrane helical protein anabaena sensory rhodopsin probed by solid state NMR
... side, 54 indicating either static disorder, or a very slow exchange (longer than 500 ms), as revealed by the absence of exchange cross peaks in the proton-driven spin diffusion 13 C- 13 C correlation spectra collected ...
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Mapa, Koyeli (2009): Conformational Dynamics of the Mitochondrial TIM23 Preprotein Translocase. Dissertation, LMU München: Medizinische Fakultät
... induce conformational changes in Hsp70s that affect the allosteric communication between the two domains of ...the conformational change could be due to the inability of Mdj1 to form stable complex with ...
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Solution Structure, Conformational Dynamics, and CD4-Induced Activation in Full-Length, Glycosylated, Monomeric HIV gp120
... While a great deal of detailed information for the structure of HIV Env has been provided by X-ray crystallography (6, 10, 22, 30, 44), most commonly for the gp120 core in complex with stabilizing ligands, such as CD4 ...
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APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8
... MD simulations. Initial structure of APOL1 C-terminus was obtained using the iterative threading assem- bly refinement server I-TASSER (Supplemental Table 3). Protein models were solvated in a TIP3P water box, and ...
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Conformational Dynamics and Thermal Cones of C-terminal Tubulin Tails in Neuronal Microtubules
... proteins that are considered to be “natively disordered” however their biological function may depend on the potential for flipping from disordered into an or- dered coil state (Uversky, 2002). In this situation the ...
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Conformational dynamics is more important than helical propensity for the folding of the all alpha-helical protein Im7
... determined conformational properties of urea-denatured Im7H3M3 and identified four independent clusters of interacting residues that corresponded to the four ...
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Protein dynamics and conformational selection in bidirectional signal transduction
... how conformational dynamics can allow for both promiscuity and specificity, let us consider ubiquitin, for which there are ample data relating to the ‘conformational selection and population shift’ ...
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Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins
... in conformational dynamics in the mutant protein construct, relative to wild type Cdc42, which were corre- lated to a reduced binding of an effector protein that in- hibits GTP hydrolysis ...that ...
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On the Ca2 + binding and conformational change in EF hand domains: Experimental evidence of Ca2 + saturated intermediates of N domain of calmodulin
... substantial crystal contacts including the hydrophobic surface, necessary for binding to protein targets [75], suggesting that crystal packing may stabilize these fully open structures, as previously suggested [58]. In ...
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Vol 3, No 6 (2014)
... second conformational polymorph of 2,5-dibenzylide- necyclopentanone which show conformational isomerism i-e two independent molecules with slightly different bond lengths, torsion angles and dihedral ...
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NMR Studies of Unnatural Amino Acid Containing Peptides and Peptidomimetics
... find out the conformation of the peptide with limited structural information such as coupling constant, spatial correlation and hydrogen bonding. Our interest is to look the conformational study of sugar amino ...
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Changes of conformation in albumin protein with temperature
... Dynamics of proteins in solution can be modelled by a complex physical system [1] yielding many interesting effects. Biopolymers such as proteins consist of monomers (amino acids) connected linearly. Thus, a chain ...
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Molecular Dynamics Simulations Towards The Understanding of the Cis Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes
... the conformational space of the substrate in the active site of ...molecular dynamics simulations are presented to explore the kinetic properties of a Pin1 substrate and its unphosphorylated ...
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Molecular Dynamics Simulations Towards The Understanding of the Cis Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes
... colleagues, Japanese fight-‐choreographers, the hairy-‐shouldered Ken N. Johnson, [and an] Islamic M.D.” (957). Jim himself says that she has had sex with “not one not two but over thirty Near Eastern medical attachés” ...
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Molecular Dynamics Simulations Towards The Understanding of the Cis Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes
... After we randomly split the original data into training and test sets, and build and evaluate both models for 200 times, Tables 10.6 and 10.7 show the statistics mean and variance of thr[r] ...
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