Conformational epitope
Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
... V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently ...V2/V3 conformational epitope ...V2/V3 conformational epitope broadly ...
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Fuzzy Inference System Mamdani to Predicting Conformational Epitope Location
... of conformational epitope prediction on Mamdani fuzzy when compared with predicted results in CED on some data have a fairly high accuracy value, and some have almost reached ...not epitope that are ...
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Characterization of a Conformational Epitope on Hepatitis B Virus Core Antigen and Quasiequivalent Variations in Antibody Binding
... Conformational epitopes may be identified from crystal structures of the antigen complexed with Fab fragments of a monoclonal antibody, and such identifications have been achieved in a few cases (e.g., see ...
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Homology Modeling and Conformational Epitope Prediction of Envelope Protein of Alkhumra Haemorrhagic Fever Virus
... B-cell conformational epitope prediction Having an acceptable model, the predic- tion of envelope protein of AHFV was un- dertaken using DiscoTope ...novel epitope propensity amino acid ...
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Attenuating Mutations in Coxsackievirus B3 Map to a Conformational Epitope That Comprises the Puff Region of VP2 and the Knob of VP3
... honey) and HRV14 (30, 35, 36). However, the finding reported here that residues in both the knob and the puff region com- prise a highly neutralizing conformational epitope was not previously reported. ...
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Characterization of a Broadly Reactive Monoclonal Antibody against Norovirus Genogroups I and II: Recognition of a Novel Conformational Epitope
... reported conformational epitope of NV3901 and NV3912 ( ), and the amino acid positions shared between the epitopes of MAb14-1, NV3901, and NV3912 ( f ) are indicated ...
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Recognition by recombinant autoimmune thyroid disease derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase
... comparable to those of serum TPO autoantibodies. TPO autoantibodies represented by the SP Fab fragments are present in all 11 patients studied, constitute a high proportion (36- 72%) of serum TPO autoantibodies in ...
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Conformational Epitope Consisting of the V3 and V4 Loops as a Target for Potent and Broad Neutralization of Simian Immunodeficiency Viruses
... B404 epitope on trimeric, but not monomeric, Env was enhanced by CD4 ...a conformational epitope consisting of the V3 and V4 loops is the target for potent and broad neutralization of ...neutralizing ...
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Isoprenylation masks a conformational epitope and enhances trans-dominant inhibitory function of the large hepatitis delta antigen.
... 7 cells transfected with various These results strongly suggest that the trans-dominant inhibitory activity of wild-type LHDAg and HDAg mutants is not caused by the primary inhibitory am[r] ...
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A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope
... E2 epitope within domain A that elicits non-neutralizing antibodies ...this epitope is outside the region being mutated, substitutions that result in a reduction in binding to both CBH-2 and CBH-4G may be ...
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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.
... ROBINSON' Received 23 August 1990/Accepted 12 October 1990 A human monoclonal antibody designated 15e is reactive with the envelope glycoprotein gpl20 of multiple isolates of human immun[r] ...
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A monoclonal thyroid stimulating antibody
... The thyrotropin receptor, also known as the thyroid-stimulating hor- mone receptor (TSHR), is the primary antigen of Graves disease. Stim- ulating TSHR antibodies are the cause of thyroid overstimulation and were ...
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Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions
... a conformational epitope recognized by a monoclonal antibody (3C3G3) by phage display, site-directed mu- tagenesis, and surface plasmon ...predicted epitope is composed of 11 amino acids within the P ...
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Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process.
... antibody epitope conformation dependence that had not been previously employed in this system, we observed that the humoral immune response to EIAV required a 6- to 8-month period in which to fully ...linear ...
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The Humoral Immune Response to Human T-Cell Lymphotropic Virus Type 1 Envelope Glycoprotein gp46 Is Directed Primarily against Conformational Epitopes
... and conformational epitopes and the antibodies elicited to these ...recognize conformational epitopes. Binding of antibodies to conformational epitopes was unaffected by antibodies to linear epitopes ...
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Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon
... a conformational epitope (418AGSEK422) within hypervariable region 7 ...neutralizing epitope in the HVR7 region of HAdV-3 hexon, successfully induced antiserum that inhibited HAdV-4 infec- ...
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Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
... Conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.. Broadly neutralizing antibodie[r] ...
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SPECTROSCOPIC AND ELECTROCHEMICAL INVESTIGATION OF BINDING OF NEVIRAPINE WITH BOVINE SERUM ALBUMIN
... The primary structure of BSA contains a single chain of about 582 amino acid residues. [30] The secondary structure of BSA is formed by 67% of α-helix of six turns and 17 disulphide bridges. [31] When ligand binds to ...
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A thermostable, chromatographically purified Ebola nano VLP vaccine
... Results: We developed a new procedure for rapid isolation of Ebola VLP using membrane chromatography that yields a filterable and immunogenic product. Disruption of VLP filaments by sonication followed by filtration pro- ...
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Cyclodextrins as the basis of molecular devices
... being determined. The new signal is found at 10.22 ppm and must be due to a nitrogen coupled proton from either of the secondary amines B or M or the amide proton I. This signal has NOE interactions with both the signals ...
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