Connexin 43 (Cx43)
Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes
... pharmacological actions converge on mitochondrial ATP-sensitive K + (mitoK ATP ) channels and PKC to confer cytoprotection against necrotic and apoptotic cell injury. However, the molecular structure of mitoK ATP ...
14
All-trans retinoic acid arrests cell cycle in leukemic bone marrow stromal cells by increasing intercellular communication through connexin 43-mediated gap junction
... (BMSCs). Connexin 43 (Cx43) is the major gap junction (GJ) protein; our previous study revealed that Cx43 expression and GJIC were decreased in acute leukemic ...on Cx43 expression and ...
9
Connexin 43 and metabolic effect of fatty acids in stressed endothelial cells
... is connexin family (Cxs) (Mroue et al. 2011). Connexin 43 (Cx43) is expressed mainly in the heart muscle and endothelial cells (Mroue et ...important Cx43 role in changes that affect ...
7
Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
... Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have ...
6
Connexin 43 mediates spread of Ca2+ dependent proinflammatory responses in lung capillaries
... endothelial connexin 43 (Cx43), or in rat lungs in which we pretreated vessels with peptide inhibitors of ...that Cx43-containing gap junctions mediate the ...
9
Genetic variation at the human connexin 43 locus but not at the connexin 40 locus is associated with left bundle branch block
... We chose a candidate gene approach to explore the association between heritable factors and QRS duration. On the basis of knock-out mice and functional studies, 9 11 we chose connexin 40 and connexin ...
8
Connexin-43: A possible mediator of heat stress effects on ram Sertoli cells
... of connexin-43, the most abundantly distributed gap junction protein of cells, was investigated in ram Sertoli cells under mild and severe heat stresses with real-time quantitative ...of ...
6
Original Article Different expression of connexin 43 between culprit arteries and non-culprit arteries and role of angiotensin II on expression of connexin 43 in non-culprit arteries
... of connexin 43 between culprit arteries and nonculprit arteries in ischemia-reperfusion model and investigate on the mechanism of nonculprit arteries lesions ...of connexin 43 was performed in ...
9
Original Article Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy
... kophilin), connexin-43, and N-cadherin was not useful in the diagnosis of ARVC ...and connexin-43 had no significant change in all subjects with ARVC and immuno- histochemical analysis for ...
8
VEGF promotes endothelial progenitor cell differentiation and vascular repair through connexin 43
... and Cx43 [18], all of which facilitate the propagation of electrical and chemical signals along the vessel ...of Cx43, and EPCs treated with Cx43 siRNA lose their therapeutic potential ...of ...
11
Modification of connexin 43 expression in vascular smooth muscle
... Single and double transfections of the smooth muscle cells using the EGFP / Cx43 I pBi5 plasmid with + dox and without -dox the addition of doxycycline to the medium containing doxycycli[r] ...
295
Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes
... GJIC maintains normal growth and differentiation of cells in many tissues. In rat liver, Cx32, a fundamental element of GJIC, becomes detectable in the late stages of gestation and reaches maximal levels about 1 week ...
11
Effects of Connexin 43 Inhibition in an Ovalbumin-induced Mouse Model of Asthma
... protein, Cx43 is predominantly expressed in alveolar epithelial and endothelial cells in the ...that Cx43 is involved in the pathogenesis of lung diseases such as ALI, cystic fibrosis, pulmonary arterial ...
10
Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease
... the Cx43 gap junctions may comprise a therapeutic target in vascular dementia, particularly in those patients with risk factors for chronic carotid artery or carotid-distribution diseases, such as smoking, ...
20
Remote ischemic preconditioning preserves Connexin 43 phosphorylation in the rat heart in vivo
... 1 μg of total RNA was reverse transcribed using the High Capacity RNA-to-cDNA Master Mix according to the manufacturer’s protocol (Applied Biosystems). The qPCR assay for Cx43 was generated by TIB MOLBIOL (Berlin, ...
7
Expression of Connexin 43 (Cx43) in Oral Submucous Fibrosis and Its Malignant Transformation to Oral Squamous Cell Carcinoma
... one cell to the other and form the gap junction. These junctions are responsible for the communication between adjacent cells in sharing secondary messengers, growth factors and ions. In humans, 21 isoforms of connexins ...
138
Internal translation of the connexin 43 transcript
... the Cx43 C-terminus) is present in a wide variety of cell lines as well as in primary human cells, and is pro- duced through internal translation in a manner that is dependent on m7G-capping, ribosomal scanning ...
6
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies
... protein connexin 43 (Cx43), but not that of the glucose transporter 1 (GLUT1) or integrin α3 (ITGA3), was low (Fig 5A, S6A–S6E Fig), consistent with the short half-life and rapid turnover of GJs in ...
26
Modulation of Cx43 and Gap Junctional Intercellular Communication by Androstenedione in Rat Polycystic Ovary and Granulosa Cells in vitro
... for Cx43 as described by El-Sabban et ...anti-connexin 43 according to the supplier’s suggestion in 5% skimmed milk for 1 hr at room temperature then for 1 hr at room temperature in 3% skimmed milk ...
12
Circulating and disseminated tumor cells from breast cancer patient derived xenograft bearing mice as a novel model to study metastasis
... as connexin 43 (Cx43), has been shown to suppress mammary tumor metastasis to the lung in a mouse model ...altered Cx43 protein that acts in a dominant-negative fashion to disrupt gap-junction ...
9