Cross-neutralizing
Papillomavirus pseudovirions packaged with the L2 gene induce cross neutralizing antibodies
... homologous neutralizing titers and homologous ELISA titers for each ...HPV16 neutralizing assay is 3.5 less sensitive than the HPV58 neutralizing assay and ...HPV16 neutralizing antibodies ...
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Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge
... prising that a 25- g MAb dose produced variable results with some MAbs and challenge viruses. To determine whether a high dose of MAb would enhance prophylaxis against clinical disease and death, 12-month-old BALB/c ...
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Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines
... of cross-neutralizing antibody epitopes in a way similar to the observation that subtle structural differences between genotypes in this region may be- stow type-specific susceptibility to ...
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Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies
... Broadly cross-neutralizing (BCN) antibodies are likely to be critical for an effective HIV ...autologous neutralizing response in CAP256 was directed at V1V2, reaching extremely high titers ( > ...
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Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants
... potent cross-neutralizing ...strong neutralizing antibodies against divergent MERS-CoV ...critical neutralizing domain covering residues 377 to ...with neutralizing mouse MAb Mersmab1 ...
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Broadly Cross-Neutralizing Antibodies in HIV-1 Patients with Undetectable Viremia
... broadly neutralizing antibodies in LTNPs to that in progressor patients with detectable levels of viremia (3, 23, 24, 46, 50, ...potent neutralizing activity was ...broadly cross-neutralizing ...
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Protection against Lethal Enterovirus 71 Challenge in Mice by a Recombinant Vaccine Candidate Containing a Broadly Cross-Neutralizing Epitope within the VP2 EF Loop
... C4), including the 150S mature virion at 2.3-Å resolu- tion (Fig. 3A) and an expanded form of 82S empty assembly intermediate at 2.88-Å resolution (Fig. 3B). Through atomic-level descriptions of two different ...
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A Protective and Broadly Cross-Neutralizing Epitope of Human Papillomavirus L2
... detectable cross- neutralizing activity against HPV18 (2,560 to ⬍ 20), suggesting that the neutralizing epitopes outside this 17-36 region are predominantly type ...as ...
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Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge
... We previously demonstrated that chronic-phase patient H IgG, infused prechallenge, could control H77 infection in human liver chimeric mice (28, 43). However, the animals could only be followed short term. The reciprocal ...
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Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence Motif
... antiviral neutralizing antibody responses of anti-V3 an- tibodies lies in the extraordinary diversity of the V3 sequence and in the resulting strict type specificity of anti-V3 neutraliz- ing ...elicited ...
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PubMedCentral-PMC4958264.pdf
... by cross- protective human antibodies ...serotype-specific neutralizing and protective antibody re- sponses, whereas repeat DENV infections lead to the induction of serotype cross-neutralizing ...
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Rapid Escape from Preserved Cross-Reactive Neutralizing Humoral Immunity without Loss of Viral Fitness in HIV-1-Infected Progressors and Long-Term Nonprogressors
... HIV-1 cross-reactive neutralizing activity in ...for neutralizing activity in a pseudovirus assay developed by Monogram ...determining cross-neutralizing activity in serum consisted of ...
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Delineating antibody recognition against Zika virus during natural infection
... and neutralizing activity of polyclon- al plasma and isolated mAbs from B cells, we have revealed complex and dynamic features of antibody response during ...extensively cross-react with DI/DII of ...
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jiz109.pdf
... of cross-neutralizing antibodies to DENV1 or DENV4 depending on the cell type used for the assay (Figure 3C and Supplementary Figure ...strongly neutralizing hMAb 5J7 qua- ternary structure epitope ...
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The Potent and Broadly Neutralizing Human Dengue Virus Specific Monoclonal Antibody 1C19 Reveals a Unique Cross Reactive Epitope on the bc Loop of Domain II of the Envelope Protein
... DII-FL epitope mapping with WNV E proteins. To begin to define the epitope specificity of our panel of MAbs, we next tested them for binding to previously designed wild-type or mutant DII-FL E proteins (Table 5) whose ...
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jiw576.pdf
... that cross-react with the 4 serotypes [8, 14]. Despite the cross-reactivity, after a limited “grace” period of cross-protection, antibodies only prevent reinfection from the same serotype (homologous ...
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nihms974625.pdf
... are cross-reactive or specific to the serotype of infection. Although cross-reactive antibodies are more abundant than type- specific antibodies in serum and MBCs, the potently neutralizing ...
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Genotype specific and cross reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (Callithrix jacchus)
... of neutralizing antibody in response to 3 different genotype of DENV-2 (Cosmopolitan, Asian I, and Asian/ American genotypes) as compared to those marmosets with homologous genotype ...infection, ...
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Evaluation of Replication and Pathogenicity of Avian Influenza A H7 Subtype Viruses in a Mouse Model
... of cross-reactivity of ...of cross-reactivity with mouse and ferret ...broadly cross-reactive antibodies that neutralized viruses from both Eurasian and North American lineages, but the converse was ...
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HIV 1 envelope glycoprotein signatures that correlate with the development of cross reactive neutralizing activity
... The Amsterdam Cohort Studies on HIV infection and AIDS, a collaboration between the Amsterdam Health Service, the Academic Medical Center of the University of Amsterdam, Sanquin Blood Supply Foundation, the University ...
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