cyclic peptide
Study of (cyclic peptide) polymer conjugate assemblies by small angle neutron scattering
... (cyclic peptide)-polymer conjugates as a versatile supramolecular motif to engineer nanotubes with defined structure and dimensions, as characterised in solution using small angle neutron scattering ...
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Evolution of Cyclic Peptide Scaffolds to Target Nucleic Acids
... The Progress Report assay completed after Round 3 of the second attempt at selection along with the Round 3 amplified phage titer indicated that the evolved phage pool had significant wildtype contamination. Wildtype M13 ...
168
Post modification strategies for polymeric cyclic peptide nanotubes
... The glycopolymer conjugates generated in Chapter 3, are an exciting material that would make an excellent candidate for non-viral gene delivery and drug delivery applications. A library of glycopolymer conjugates could ...
209
Tunable length of cyclic peptide–polymer conjugate self assemblies in water
... hypothesise that our conjugates become highly charged at pH 2. Nevertheless, we conclude that the gradual increase of the repulsive electrostatic interactions, due to the protonation of the amine groups of pDMAEMA ...
6
Supramolecular cyclic peptide polymer nanotubes as drug delivery vectors
... to cyclic peptide-polymer conjugates, which were critically ...a cyclic peptide, using an active ester ligation ...a cyclic peptide modified with CTA groups clearly revealed ...
177
Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool
... a cyclic 17-amino acid β-defensin analog featuring a single disulfide ...antimicrobial cyclic peptide), combines the internal hydrophobic domain of hBD1 and the C-terminal charged region of ...novel ...
17
Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422
... a cyclic peptide containing E2 residues 412 to 422 (C-epitope I) but not to the linear ...the cyclic peptide in the antibody-combining site is rotated by 180° compared to the orientations of ...
15
Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist
... a cyclic peptide antagonist of integrin αvβ3 to rabbits with antigen-induced arthritis early in disease resulted in inhibition of synovial angio- genesis and reduced synovial cell infiltrate, pannus ...
9
Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis
... the cyclic citrullinated peptide 2 assay (CCP2) [1-3]. The cyclic peptide(s) in the CCP2 have no homology with known pro- teins [1] and improved the sensitivity of the first test to become ...
9
Brucyclin, a novel antimicrobial peptide structurally designed from the antibacterial plant peptide, Brucin
... synthesized peptide (Vincent et ...the peptide is also a concomitant increase the antimicrobial activity (Ingrid et ...the cyclic by adding glutamine at the N-terminal of Brucin as there is evidence ...
8
Performance Assessment of the GenoType MTBDRsl Test and DNA Sequencing for Detection of Second Line and Ethambutol Drug Resistance among Patients Infected with Multidrug Resistant Mycobacterium tuberculosis
... aminoglycosides/cyclic peptide (AG/CP), and EMB in the gyrA, rrs, and embB genes (for the GenoType MTBDRsl test) and gyrA, gyrB, rrs, eis, embC, embA, embB, and embR genes (for DNA sequencing) was compared ...
7
Characterization of the Dynamics of Beta Sheet Formation by Time-Resolved Infrared Spectroscopy and Computational Modeling
... H3 peptide were fit to bi-exponential equations, uncertainty was present regarding the appropriate model ...H3 peptide conforms to a two-state ...H3 peptide is shown in Equation ...
159
Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
... There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant.. P-value o[r] ...
5
Cyclic Adenosine Monophosphate Mediation of Peptide Neurohormone Effects on the Lobster Cardiac Ganglion
... Four lines of evidence are presented that cyclic adenosine monophosphate cAMP mediates the effects of peptide on the ganglion, but does not play a significant role in 5-HT action: 1 exog[r] ...
22
Involvement of cyclic GMP in the release of stereotyped behaviour patterns in moths by a peptide hormone
... cecropia moths after injection with various materials arrow a, intact animal injected with 1 unit of eclosion hormone; 6, isolated abdomen injected with 1 unit of hormone; c, d, isolated[r] ...
12
Article: Quality control and interest of the determination of anti-CCP antibodies and rheumatoid factor in the diagnosis of rheumatoid arthritis
... of cyclic peptides, the sensitivity was increased because the peptide adopt a structure in which the citrulline moiety is optimally exposed for antibody binding (Schellekens et ...single cyclic ...
10
Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody
... summary, cyclic and acyclic analogs (native or Aib con- taining) were identified in which the tight binding to 4E10 (10 nM) was maintained (Table 2) and yet the possible backbone conformations adopted by the ...
8
Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... Glucagon-like peptide-1 (GLP-1) is one of the transcrip- tion products from the proglucagon ...a peptide hormone predominately produced by intestinal endocrine ...
9
Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta analysis
... The cardiovascular effects of ANP or BNP are vaso- dilation and a reduced sympathetic tone in the periph- eral vasculature [9]. ANP and BNP bind to natriuretic peptide receptor A, which increases cGMP and dilates ...
10
Serial determination of cyclic citrullinated peptide autoantibodies predicted five year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis
... 24. Boire G, Cossette P, de Brum-Fernandes AJ, Liang P, Nyonsenga T, Zhou ZJ, Carrier N, Daniel C, Menard HA: Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as ...
8