Cyclin A/CDK2, Ciz1-N471 and Replication Initiation
Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... between cyclin A-CDK2 and ...are cyclin A-CDK2 and Ciz1 binding partners, but that Ciz1 is actually also a substrate of this cyclin-CDK ...between Ciz1 and ...
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Drosophila double parked is sufficient to induce re replication during development and is regulated by cyclin E/CDK2
... on cyclin E/CDK2 ...with CDK2 protein and activity in ...other CDK2-dependent mechanisms for ...genomic replication suggest that phosphorylation of the N terminus of Dup protein may be ...
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Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity.
... DNA replication which allows for virion production (8, ...inhibit cyclin E kinase activity in both keratinocytes and U20S cells expressing E7, indicating that E7 was not directly interfering with p21 ...
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Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2
... the cyclin E-Cdk2 kinase is most likely a cellular partner of the BPV replicative helicase ...E1, cyclin E, and Cdk2 added to Xenopus egg extracts through translation of their respective mRNAs ...
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Emerging players in the initiation of eukaryotic DNA replication
... using purified proteins has so far been unsuccessful, indicating that there are still important players missing from the orchestra. Investigations in other less-studied species may lead us to some valuable clues. In ...
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DNA Replication-Initiation Proteins in Eukaryotic Cells
... DNA replication is a highly regulated cellular process in proliferating cells, involving cell cycle dependent assembly of DNA replication-initiation proteins (DRIPs) onto origins of ...as ...
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The role of CDK in the initiation step of DNA replication in eukaryotes
... two replication proteins, Sld2 and ...DNA replication in the absence of CDK ...the initiation of DNA repli- ...the initiation step of DNA replication in a similar manner, that is, ...
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Requirement for Cellular Cyclin-Dependent Kinases in Herpes Simplex Virus Replication and Transcription
... (HSV) replication: (i) certain mutant HSV strains are replication impaired during infection of cells in the G 0 /G 1 but not in the G 1 /S phase of the cell cycle, (ii) several late-G 1 /S-phase-specific ...
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Roscovitine, a Cyclin-Dependent Kinase Inhibitor, Prevents Replication of Varicella-Zoster Virus
... VZV replication, since many of the cell types infected by VZV are similar to those infected by ...VZV replication at levels that were not cytotoxic, did not in- duce apoptosis in the host cells, and were ...
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Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.
... for cyclin-dependent kinases ...DNA) replication function of Py T ...DNA replication functions of T278A and DM, but not T187A, mutant T Ags were abolished both in vivo and in ...by cyclin ...
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Cell Cycle Regulation by Kaposi's Sarcoma-Associated Herpesvirus K-bZIP: Direct Interaction with Cyclin-CDK2 and Induction of G1 Growth Arrest
... and initiation of viral DNA replication to take ...inhibit CDK2 and induce growth ...above, CDK2 phos- phorylation of p21 and p27 targets these molecules for degra- ...
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Initiation of Human DNA Replication in Vitro Using Nuclei from Cells Arrested at an Initiation-competent State*
... Kingdom Initiation of human DNA replication is investigated in vitro, using initiation-competent nuclei isolated from cells arrested in late G 1 phase by a 24-h treatment with ...DNA ...
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Identifying substrates of CDK2: cyclin A.
... 5.4. A typical round of screening for substrates of GST-CDK2:cyclin A3. Figure 5-3 shows the results of a typical round of screening using altered mobility of translated proteins in the presence of ...
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A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
... of Cyclin E expression is observed was not excluded that inhibition of Cyclin E/Cdk2 by inhibitory phosphorylation of the Cdk2 subunit, as known to occur in cultured mammalian cells, might ...
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Initiation of adenovirus DNA replication.
... Adenovirus DNA was synthesized in vitro in the presence of [3H]dTTP (-4*) either with protein-free viral DNA (A) or with the DNA-protein complex as the template (B, C, and D). Samples we[r] ...
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PIWIL2 promotes progression of non small cell lung cancer by inducing CDK2 and Cyclin A expression
... regulates CDK2 and Cyclin A expression in NSCLC cells We next investigated the mechanism whereby PIWIL2 causes G2/M cell cycle arrest by measuring the expres- sion of Cyclins and ...CDK4, Cyclin B or ...
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Initiation of Deoxyribonucleic Acid Replication in Escherichia
... In Escherichia coli growing at different rates, the ratio of cell mass to the number of chromosome origins tended to be constant at the time of the initiation of deoxyribonucleic acid (D[r] ...
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INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
... Sunil H. Ganatra* and Amita S. Suchak Department of Chemistry, Institute of Science, Civil Lines, Nagpur-440 001, Maharashtra, India ABSTRACT Cyclin dependent kinases (CDKs) are known as cell cycle regulators in ...
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Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
... ABSTRACT Cyclin E/Cdk2 kinase activity is frequently deregulated in human cancers, resulting in impaired ...that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival Bcl-2 family ...
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Initiation of Hepatitis Delta Virus Genome Replication
... molecular-weight ribonucleoprotein (RNP) structures. After transfection of these RNPs into human cells, we detected HDV genome replication, as assayed by Northern analysis or immunofluorescence microscopy. Our ...
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