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Cyclo-Oxygenase-2

Comparative Study for Preventive Effects of Intra Abdominal Adhesion Using Cyclo Oxygenase 2 Enzyme (COX 2) Inhibitor, Low Molecular Weight Heparin (LMWH), and Synthetic Barrier

Comparative Study for Preventive Effects of Intra Abdominal Adhesion Using Cyclo Oxygenase 2 Enzyme (COX 2) Inhibitor, Low Molecular Weight Heparin (LMWH), and Synthetic Barrier

... Purpose: Postoperative adhesion is the most frequent complication of abdominal surgery. Therefore, we investigated the individual effects of synthetic barrier [hyal- uronic acid/carboxymethylcellulose (HA/CMC)] and ...

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Epstein-Barr Virus Protein Can Upregulate Cyclo-Oxygenase-2 Expression through Association with the Suppressor of Metastasis Nm23-H1

Epstein-Barr Virus Protein Can Upregulate Cyclo-Oxygenase-2 Expression through Association with the Suppressor of Metastasis Nm23-H1

... Nm23-H1. Cyclo-oxygenase-2 (COX-2), an inducible enzyme important in inflammation, is overexpressed in a variety of cancers and can influence cell ...E 2 levels increased with Nm23-H1 ...

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Role of Selective Cyclo Oxygenase 2 Inhibitor Celecoxib in Canine Osteosarcoma Cell Culture

Role of Selective Cyclo Oxygenase 2 Inhibitor Celecoxib in Canine Osteosarcoma Cell Culture

... that cyclo-oxygenase-2 (Cox2) is related to the development and pro- gression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, “activated” endothelial ...

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Faecal blood loss with aspirin, nonsteroidal anti inflammatory drugs and cyclo oxygenase 2 selective inhibitors: systematic review of randomized trials using autologous chromium labelled erythrocytes

Faecal blood loss with aspirin, nonsteroidal anti inflammatory drugs and cyclo oxygenase 2 selective inhibitors: systematic review of randomized trials using autologous chromium labelled erythrocytes

... Introduction Faecal blood loss has been measured using autologous erythrocytes labelled with radioactive chromium for several decades, using generally similar methods. We conducted a systematic review of studies ...

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Mechanisms underlying the growth inhibitory effects of the cyclo oxygenase 2 inhibitor celecoxib in human breast cancer cells

Mechanisms underlying the growth inhibitory effects of the cyclo oxygenase 2 inhibitor celecoxib in human breast cancer cells

... The results presented here clearly show that celecoxib strongly suppresses cell growth and proliferation in both human breast cancer cell lines (Fig. 1b). However, the mech- anism of antitumor effect is dependent upon ...

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Dynamic compression counteracts IL 1β induced inducible nitric oxide synthase and cyclo oxygenase 2 expression in chondrocyte/agarose constructs

Dynamic compression counteracts IL 1β induced inducible nitric oxide synthase and cyclo oxygenase 2 expression in chondrocyte/agarose constructs

... Overall, these observations indicate a hypothetical mechanism for the activation of iNOS by IL-1β that are, respectively, dependent on p38 MAPK signalling and could involve activa- tion of other MAPKs. In free-swelling ...

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Candida albicansinduces cyclo oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular regulated kinase 1/2 dependent pathway

Candida albicansinduces cyclo oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular regulated kinase 1/2 dependent pathway

... Total RNA was isolated from cells after a 12-h co-culture of synovial fibroblasts and C. albicans using easy-BLUE Total RNA Extraction Kit (iNtRON Biotechnology, Gyeonggi-do, Korea). For first strand cDNA synthesis, 3 μg ...

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Cyclo oxygenase 2 selective inhibitors and nonsteroidal anti inflammatory drugs: balancing gastrointestinal and cardiovascular risk

Cyclo oxygenase 2 selective inhibitors and nonsteroidal anti inflammatory drugs: balancing gastrointestinal and cardiovascular risk

... All of these drugs (aspirin, NSAIDs, and coxibs) may also be associated with increased risk of cardiovascular harm. There appears to be a dose-related effect of aspirin causing myocardial infarction in a randomised trial ...

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First dose analgesic effect of the cyclo oxygenase 2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double blind, placebo controlled comparison with celecoxib [NCT00267215]

First dose analgesic effect of the cyclo oxygenase 2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double blind, placebo controlled comparison with celecoxib [NCT00267215]

... The three main hypotheses of the primary efficacy variable (APID between the baseline pain assessment and the mean of the 3-hour and 5-hour actual pain assessments after the first dose of study medication) were tested in ...

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Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

... of cyclo-oxygenase 2 (COX2), usually accompanied by in- creased iNOS, in MS lesions and opined that COX2 pro- moted excitotoxic death and damage of oligodendrocytes by coupling with ...

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Evolving guidelines in the use of topical nonsteroidal anti inflammatory drugs in the treatment of osteoarthritis

Evolving guidelines in the use of topical nonsteroidal anti inflammatory drugs in the treatment of osteoarthritis

... tive cyclo-oxygenase-2 (COX-2) inhibitors were developed because they were thought to be safe alternatives for patients at a greater risk for peptic ulcer disease or gastro- intestinal ...

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Health Related Quality of Life among Osteoarthritis Patients: A Comparison of Traditional Non Steroidal Anti Inflammatory Drugs and Selective COX 2 Inhibitors in the United Arab Emirates Using the SF 36

Health Related Quality of Life among Osteoarthritis Patients: A Comparison of Traditional Non Steroidal Anti Inflammatory Drugs and Selective COX 2 Inhibitors in the United Arab Emirates Using the SF 36

... Objectives: Osteoarthritis (OA) has a dramatic impact on patients’ health related quality of life (HRQoL). Chronic use of analgesics and anti-inflammatory medications for pain management may improve symptoms but on long ...

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The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

... Although the factors responsible for the cytotoxicity of cyclooxygenase-2 in cerebral injury induced by ischemia remain to be clearly defined, it is likely that one of the mechanisms is related to production of ...

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EVALUATION OF AQUEOUS FRUIT EXTRACT OF TAMARINDUS INDICA (L) FOR INHIBITION OF TUMOR NECROSIS FACTOR a AND CYCLO OXYGENASE ENZYMES IN EXPERIMENTAL ANIMAL

EVALUATION OF AQUEOUS FRUIT EXTRACT OF TAMARINDUS INDICA (L) FOR INHIBITION OF TUMOR NECROSIS FACTOR a AND CYCLO OXYGENASE ENZYMES IN EXPERIMENTAL ANIMAL

... process. Most of the inflammatory mediators are newly synthesized in the injured tissues or by the floated immune cells during an inflammatory event. Pathological organisms such as bacteria activate NFΚβ through ...

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Immunoexpression of constitutive and inducible cyclo-oxygenase isoforms in the rat foetal and maternal digestive tract

Immunoexpression of constitutive and inducible cyclo-oxygenase isoforms in the rat foetal and maternal digestive tract

... COX-2 immunostaining with applied monoclonal antibody was nuclear and/or cytoplasmic. The former was noted mainly in the epithelial cells. In the mater- nal samples an inconsistent positive reaction was seen in ...

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Cells of the synovium in rheumatoid arthritis  Synovial fibroblasts

Cells of the synovium in rheumatoid arthritis Synovial fibroblasts

... A major factor contributing to synovial growth is the resis- tance of RASF against apoptosis, which can be linked to distinct anti-apoptotic molecules such as FLICE inhibitory protein (FLIP) and sentrin (SUMO-1). FLIP ...

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The Association between Cyclo-oxygenase Inhibitor Medications and Clinical Relapse in Inflammatory Bowel Disease: Review of Current Perspectives

The Association between Cyclo-oxygenase Inhibitor Medications and Clinical Relapse in Inflammatory Bowel Disease: Review of Current Perspectives

... However, prostaglandins also have anti- inflammatory properties. For example PGE2 has anti-inflammatory actions on innate immune cells, such as neutrophils, monocytes, and natural killer cells [36]. Additionally, ...

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Thesis

Thesis

... Proteorhodopsins are retinal-binding membrane proteins that may act as light-driven proton pumps to generate energy that can be used for metabolism and growth. These proteins were originally characterized in prokaryotes, ...

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Heme Oxygenase-2 Is Neuroprotective in Cerebral Ischemia

Heme Oxygenase-2 Is Neuroprotective in Cerebral Ischemia

... In the present study, we demonstrate that neural damage following middle cerebral artery occlusion (MCAO), a model of focal ischemia of vascular stroke, is substantially worsened in HO2 [r] ...

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Cyclomatrix polyphosphazenes frameworks (Cyclo POPs) and the related nanomaterials : synthesis, assembly and functionalisation

Cyclomatrix polyphosphazenes frameworks (Cyclo POPs) and the related nanomaterials : synthesis, assembly and functionalisation

... The solid TPP-PZS particles emit a bright red fluorescence both in powder state and in solution because the isolation of porphyrin moieties by the cyclotriphosphazene rings (Fig. 16c) effectively prevents the excited ...

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