Cytochrome P 450
The relationship of uterine leiomyomata and genetic polymorphisms of Cytochrome P-450 1A1, Cytochrome P-450 1B1, and Catechol-O-Methyltransferase
... Uterine leiomyomata (fibroids) are hormone-dependent tumors that disproportionately affect African Americans compared to Whites. Single nucleotide polymorphisms (SNPs) in Cytochrome P-450 1A1 ...
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Relationship between alveolar PO2 and the rate of p nitroanisole O demethylation by the cytochrome P 450 pathway in isolated rabbit lungs
... of p-nitrophenol production was approximately equal to ...wt. p-Nitrophenol production was unaltered when O2 in the ventilating gas was decreased to 1%, but it was depressed reversibly when alveolar O2 WAS ...
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LKM 1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P 450 monooxygenase
... LKM-1 autoantibodies, which are associated with autoimmune chronic active hepatitis, recognize P450IID6, a cytochrome P-450 monooxygenase. The reactivities of 26 LKM-1 antisera were tested with a ...
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Leukotriene B4 omega hydroxylase in human polymorphonuclear leukocytes Partial purification and identification as a cytochrome P 450
... naphthoflavone, azide, cyanide, catalase, and superoxide dismutase. Finally, isolated PMN membranes exhibited a carbon monoxide difference spectrum with a peak at 452 nm. Thus, we have partially purified the LTB4 ...
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Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species specific nested PCR amplification of a cytochrome P 450 lanosterol alpha demethylase (L1A1) gene fragment
... Rapid Detection and Identification of Candida albicans and Torulopsis Candida glabrata in Clinical Specimens by SpeciesSpecific Nested PCR Amplification of a Cytochrome P-450 Lanosterol-[r] ...
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Primaquine ineligibility in anti relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P 450 2D6 polymorphisms
... The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical ...
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A REVIEW ON GENETIC POLYMORPHISM OF CYTOCHROME P-450 2C19 AND ITS CLINICAL VALIDITY
... Cytochrome P-450 (CYP) enzyme system refers to a group of related enzymes or isoenzymes located in the endoplasmic reticulum and expressed mainly in the ...This cytochrome P-450 ...
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Role of Cytochrome P 450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs
... Cytochrome P-450 (C-P450) is found in the lung and may modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical ...
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The kidney cytochrome P 450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading
... of P-450 2C23 (1, 2) show that stere- oselectivity is an intrinsic property of the protein cata- lyst, not determined and/or affected by the microsomal membrane environment or protein ...with ...
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Role of cytochrome P 450 in reperfusion injury of the rabbit lung
... fluid. P-450 inhibitors also prevented the increase in lung tissue levels of thiobarbituric acid reactive products in the ...model. P-450 inhibitors did not block enhanced ...
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Metabolism of estradiol in liver cell culture Differential responses of C 2 and C 16 oxidations to drugs and other chemicals that induce selective species of cytochrome P 450
... These data indicate that the C-2 and C-16 oxidations of estradiol take place in cultured avian hepatocytes and that the extent of metabolism at these positions on the hormone molecule ca[r] ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... Cotransfection of individual retinoic acid receptors RARs or retinoid X receptor-a RXR-a and a chloramphenicol acetyl transferase CAT reporter plasmid containing a retinoic acid responsi[r] ...
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Purification of a human liver cytochrome P 450 immunochemically related to several cytochromes P 450 purified from untreated rats
... cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of ...rat P-450s. A human liver P-450, termed HLx, was purified and found by immunochemical ...
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1201.pdf
... Cytochrome P-450 can also carry out oxidations of hydrocarbons in the presence of iodosyl benzene and peroxyacid monooxygen donors (Hrycay and O'Brien, ...involved, cytochrome ...
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Biodegradation of Caffeine by Trichosporon asahii Isolated from Caffeine Contaminated Soil
... the cytochrome P-450 enzyme system, resulted inhibition of biomass production relative to positive control implicating the utilization of this enzyme system in caffeine ...
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Amelioration of CCl4-induced hepatosuppression by Spinacia oleracea L. leaves in wistar albino rats
... marker enzymes like GGT (gamma glutamyl transferase), AST, ALT (aspartate and alanine transaminases), LDH (lactate dehydrogenase), SDH (sorbitol dehydrogenase), GDH (glutamate dehydrogenase), ALP (alkaline phosphatase) ...
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Hereditary Tyrosinemia and the Heme Biosynthetic Pathway PROFOUND INHIBITION OF δ AMINOLEVULINIC ACID DEHYDRATASE ACTIVITY BY SUCCINYLACETONE
... erythrocytes and from mouse and bovine liver. Our data indicate that succinylacetone is an extremely potent competitive inhibitor of ALA dehydratase in human as well as in animal tissues. By using purified preparations ...
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Possible role of P 450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole
... lium abolished the dilation, demonstrating a crucial role of the endothelium. Inhibition of either NO or PG synthesis, how- ever, was without effect, while inhibition of EETs synthesis or cytochrome ...
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1200.pdf
... Benzo[a]pyrene was extensively studied to determine its metabolites, and their mutagenicity and carcinogenicity, figure 7 (Conney, 1982). In the presence of purified hepatic cytochrome P-450, BaP ...
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CYP11A1 and PCOS susceptibility were examined. Seven SNPs in CYP11A1 were genotyped using the MassARRAY iPLEX platform in 285 PCOS patients and 299 control individuals.
... Abstract: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause of female subfertility. The cytochrome P-450 11A1 (CYP11A1) gene encodes the key ...
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