cytochrome(s) P-450
The relationship of uterine leiomyomata and genetic polymorphisms of Cytochrome P-450 1A1, Cytochrome P-450 1B1, and Catechol-O-Methyltransferase
... Uterine leiomyomata (fibroids) are hormone-dependent tumors that disproportionately affect African Americans compared to Whites. Single nucleotide polymorphisms (SNPs) in Cytochrome P-450 1A1 ...
156
A REVIEW ON GENETIC POLYMORPHISM OF CYTOCHROME P-450 2C19 AND ITS CLINICAL VALIDITY
... Enzymes responsible for the activation and metabolism of drugs and other compounds in humans show wide inter-individual variation in their protein expression or catalytic activity, resulting in unique drug metabolism ...
6
Primaquine ineligibility in anti relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P 450 2D6 polymorphisms
... The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical ...
6
Role of Cytochrome P 450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs
... Cytochrome P-450 (C-P450) is found in the lung and may modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical ...
9
Leukotriene B4 omega hydroxylase in human polymorphonuclear leukocytes Partial purification and identification as a cytochrome P 450
... naphthoflavone, azide, cyanide, catalase, and superoxide dismutase. Finally, isolated PMN membranes exhibited a carbon monoxide difference spectrum with a peak at 452 nm. Thus, we have partially purified the LTB4 ...
12
Relationship between alveolar PO2 and the rate of p nitroanisole O demethylation by the cytochrome P 450 pathway in isolated rabbit lungs
... of p-nitroanisole, a model substrate for cytochrome P-450 -linked mixed-function oxidation, was evaluated in the isolated rabbit lung perfused with Krebs-Ringer bicarbonate ...product, ...
6
Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species specific nested PCR amplification of a cytochrome P 450 lanosterol alpha demethylase (L1A1) gene fragment
... Rapid Detection and Identification of Candida albicans and Torulopsis Candida glabrata in Clinical Specimens by SpeciesSpecific Nested PCR Amplification of a Cytochrome P-450 Lanosterol-[r] ...
6
LKM 1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P 450 monooxygenase
... LKM-1 autoantibodies, which are associated with autoimmune chronic active hepatitis, recognize P450IID6, a cytochrome P-450 monooxygenase. The reactivities of 26 LKM-1 antisera were tested with a ...
10
The kidney cytochrome P 450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading
... of P-450 2C23 (1, 2) show that stere- oselectivity is an intrinsic property of the protein cata- lyst, not determined and/or affected by the microsomal membrane environment or protein ...with ...
11
MICROSOME-MEDIATED BENZO[A]PYRENE-DNA BINDING AND INHIBITION BY CYTOSOLIC FRACTIONS FROM LIVER AND SKIN OF ADULT AND WEANLING RATS
... In order to prepare microsomes and cytosols from liver and epiderm, first the back of the animals was shaved with an electric clipper. Adult and young rats were sacrificed by cervical dislocation and a portion of the ...
5
Role of cytochrome P 450 in reperfusion injury of the rabbit lung
... fluid. P-450 inhibitors also prevented the increase in lung tissue levels of thiobarbituric acid reactive products in the ...model. P-450 inhibitors did not block enhanced ...
9
Amelioration of CCl4-induced hepatosuppression by Spinacia oleracea L. leaves in wistar albino rats
... marker enzymes like GGT (gamma glutamyl transferase), AST, ALT (aspartate and alanine transaminases), LDH (lactate dehydrogenase), SDH (sorbitol dehydrogenase), GDH (glutamate dehydrogenase), ALP (alkaline phosphatase) ...
12
1200.pdf
... Benzo[a]pyrene was extensively studied to determine its metabolites, and their mutagenicity and carcinogenicity, figure 7 (Conney, 1982). In the presence of purified hepatic cytochrome P-450, BaP ...
122
Purification of a human liver cytochrome P 450 immunochemically related to several cytochromes P 450 purified from untreated rats
... cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of ...rat P-450s. A human liver P-450, termed HLx, was purified and found by immunochemical ...
7
1201.pdf
... The active site of cytochrome P-450 contains a single iron protoporphyrin IX prosthetic group, and it is here that dioxygen is bound, reduced and activated. An overview of its catalytic cycle is ...
70
Assessment of Association Cytochrome 450 Gene Polymorphism with Pathogenesis and Course of H V in Uzbek Population
... of cytochrome P450. Cytochrome P450 (CYP) is a group of enzymes performing not only the metabolism of drugs and other xenobiotics, but also participate in the synthesis glucocorticosteroid hormones, ...
10
Possible role of P 450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole
... Inhibiting cytochrome P-450 ...inhibits cytochrome P-450–dependent arachidonate metabolism and thereby decreases EETs ...
9
CYP11A1 and PCOS susceptibility were examined. Seven SNPs in CYP11A1 were genotyped using the MassARRAY iPLEX platform in 285 PCOS patients and 299 control individuals.
... Abstract: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause of female subfertility. The cytochrome P-450 11A1 (CYP11A1) gene encodes the key ...
7
Additive Hepatoprotection of Ranitidine with Vitamin E in Rifampicin Induced Hepatotoxicity in Rats
... of cytochrome P-450 enzyme ...of P-450 enzyme systems, in an effort to avoid the “hormonal” antiandrogenic influence of cimetidine upon the expected hepatic regeneration ...
14
The nonerythropoietic component of early bilirubin
... of cytochrome P- 450 synthesis showed a minor increase in early labeling when glycine-2- 14 C but not when delta ALA-4- 14 C was used as ...and cytochrome P-450 synthesis but ...
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