Cytoplasmic dynein
Conformational Changes in the Adenovirus Hexon Subunit Responsible for Regulating Cytoplasmic Dynein Recruitment
... protein cytoplasmic dynein following virion entry. Dynein recruitment is cru- cial for capsid transport to the nucleus and requires the transient exposure of AdV5 hexon to low pH, presumably ...
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A Common Mechanism for Cytoplasmic Dynein-Dependent Microtubule Binding Shared among Adeno-Associated Virus and Adenovirus Serotypes
... in the majority of the experiments described here, these data likely reflect the native interaction of AAV capsids with mi- crotubules since Cy3-AAVs were competitively inhibited by excess, unconjugated AAV2 capsid ...
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The Gene for the Intermediate Chain Subunit of Cytoplasmic Dynein Is Essential in Drosophila
... motor cytoplasmic dynein powers a variety of intracellular transport events that are essential for cellular and developmental ...the dynein complex are important for the specialization of ...
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Cytoplasmic Dynein and Dynactin Coordinate Microtubule Dynamics at the Growing Plus End
... by cytoplasmic dynein and its partner complex ...of dynein and dynactin localizes to the microtubule plus end and to the cortex, where we hypothesized that they might not be solely poised to initiate ...
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An Examination Of The Cytoplasmic Dynein Stepping Mechanism At The Single Molecule Level
... to cytoplasmic dynein via two inserted biotinylation sites in AAA5 and AAA6 of the ring domain and rotational motions of the dynein ring were measured in real time using a home-built optical system ...
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The Herpes Simplex Virus 1 UL34 Protein Interacts with a Cytoplasmic Dynein Intermediate Chain and Targets Nuclear Membrane
... of cytoplasmic dynein motor protein and of the location of the fragments used for generation of GST–IC-1a fusion protein and for in vitro ...of cytoplasmic dynein (IC-1a), which was mapped to ...
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Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates
... to undergo normal ciliogenesis, and any cilium-like structures that do form are reabsorbed (Pazour et al., 1999; Pazour et al., 1998). mD2LIC can associate with DHC2 (Grissom et al., 2002; Perrone et al., 2003), ...
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Cargo Specific Regulation Of Cytoplasmic Dynein By Effector Proteins
... of cytoplasmic dynein drives the transport of a wide array of cargos, including endosomes, RNA granules, and mitochondria (van Niekerk et ...of dynein are modulated by the binding of cargo-specific ...
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Cytoplasmic Dynein LC8 Interacts with Lyssavirus Phosphoprotein
... the dynein-encoding se- quence started in frame 78 to 102 nucleotides upstream from the classical start ...the dynein open reading frames in such a way that the fusion protein could only be produced ...
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Ebolavirus VP35 Interacts with the Cytoplasmic Dynein Light Chain 8
... The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic ...
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Small Peptide Inhibitors Disrupt a High-Affinity Interaction between Cytoplasmic Dynein and a Viral Cargo Protein
... 18). Dynein is a microtubular motor protein, part of a large macromolecular complex called the microtubular motor ...complex. Dynein is involved in early stages of the viral life cycle of diverse infec- ...
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Circovirus Transport Proceeds via Direct Interaction of the Cytoplasmic Dynein IC1 Subunit with the Viral Capsid Protein
... the cytoplasmic dynein tail and participate in linking dynein to physiological forms of the cargo (66, ...of dynein recruitment is not well understood for any ...for dynein-based ...
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Analysis of a zebrafish dync1h1mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development
... Here we report the identification of a new zebrafish mutant, cannonball (cnb), which affects the dynein cyto- plasmic 1 heavy chain 1 (dync1h1) locus. Using cnb, we studied the roles of Dynein1 in developing ...
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Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules
... of dynein motor from PDB 3VKG and stalkhead from PDB 3J1T; see Methods and Supplementary Figs ...superposed dynein configuration on adjacent protofilaments are ...
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Cytoplasmic Dynein Function Is Essential in Drosophila melanogaster
... Further characteriza- tion of the Dhc64C mutations will enable us to define cellular and developmental processes requiring cyto- plasmic dynein function, to begin to disse[r] ...
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Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules
... (a) Cartoon depicting the measurement of distance between ring centre and MT surface, which is plotted in (b). Also shown are parameters used in trigonometric deduction of stalk angle and stalkhead position. This assumes ...
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Molecular and Cellular Approaches Toward Understanding Dynein-Driven Motility
... and dynein are the molecular motors that drive this long range transport on the actin and microtubule ...of cytoplasmic dynein driving active retrograde transport in ...of dynein, the ...
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Analyses of Dynein Heavy Chain Mutations Reveal Complex Interactions Between Dynein Motor Domains and Cellular Dynein Functions
... Figure 3 (A) Schematic representation of cytoplasmic dynein heavy chain from N. crassa showing the mutations ana- lyzed. The relative positions of dynein heavy chain mutations are shown with ...
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Muscle length and myonuclear position are independently regulated by distinct Dynein pathways
... position. Cytoplasmic Dynein (Dynein) is a crucial factor in both ...anchored Dynein pulls microtubule minus ends and the attached nuclei towards itself (Gönczy, 2002; Tsai et ...growth, ...
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A Screen for Dynein Synthetic Lethals in Aspergillus nidulans Identifies Spindle Assembly Checkpoint Genes and Other Genes Involved in Mitosis
... Cytoplasmic dynein is a ubiquitously expressed microtubule motor involved in vesicle transport, mitosis, nuclear migration, and spindle ...of cytoplasmic dynein, although not lethal, severely ...
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