DENV-4
Development and characterization of serotype specific monoclonal antibodies against the dengue virus 4 (DENV 4) non structural protein (NS1)
... with DENV-4 rNS1, and detected by B-8A6F2 showed reactivity of the bio- tinylated 8A6F2 to DENV-4 rNS1 protein, suggesting the loss of antigen-antibody binding in NS1 capture ELISA format ...
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Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody
... two DENV-4 antigenic variants was ...neutralized DENV-4 before and after adsorption to the cell surface equally efficiently, suggesting that the antibody neutralized primarily at a step after ...
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Accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a DENV 4 epidemic
... Differing performances according to serotype were also recently described in a meta-analysis evaluating two NS1 ELISA tests for early dengue detection [18]. The study concluded that Platelia™ NS1 and NS1 Panbio® tests ...
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Improvement of the Dengue Virus (DENV) Nonhuman Primate Model via a Reverse Translational Approach Based on Dengue Vaccine Clinical Efficacy Data against DENV-2 and -4
... by DENV has increased dramatically worldwide over recent decades ...from DENV-1, -2, -3, and -4 ...against DENV-4 ...against DENV-2 ...
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Click here to download PDF version of the article !
... Results: The most common clinical symptoms were fever, thrombocytopenia, rash and elevated liver enzymes. The demon- stration of the Dengue RNA in 5.16% samples, the detection of Dengue specific IgM antibodies in 18% ...
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1-s2.0-S0264410X18304110-main.pdf
... tetravalent DENV vaccine in any of three vaccination groups (PRE-F17, TDEN F17, and TDEN F19) [49] were selected for DENV-specific antibody depletion to estimate levels of type- specific and cross-reactive ...
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Utility of a Commercial Nonstructural Protein 1 Antigen Capture Kit as a Dengue Virus Diagnostic Tool
... Platelia DENV NS1Ag test: (i) 63 anti-DENV-IgM-positive convalescent-phase samples (defined as samples collected ⱖ5 DPO) for which there was a paired acute-phase sample (collected ⬍5 DPO) that tested ...
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Validation of the Pockit Dengue Virus Reagent Set for Rapid Detection of Dengue Virus in Human Serum on a Field Deployable PCR System
... Point-of-care DENV detection with good sensitivity and specificity enables timely early diagnosis of DENV infection, facilitat- ing effective disease management and control, particularly in regions of low ...
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Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection
... with DENV-1, DENV-2, or DENV-3, to date, remarkably few strongly neutralizing type-specific anti-DENV-4 MAbs have been reported: these include three unmapped mouse MAbs (UH-6C3, ...
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Development of an Internally Controlled Real Time Reverse Transcriptase PCR Assay for Pan Dengue Virus Detection and Comparison of Four Molecular Dengue Virus Detection Assays
... where DENV is endemic, there were no clinical samples with de- tectable levels of the DENV-4 ...for DENV-4 has been documented in our laboratory for all of the assays included in this ...
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Invasion and Maintenance of Dengue Virus Type 2 and Type 4 in the Americas
... when DENV-4 was first reported in the ...of DENV-4, the progress of DENV-2 sub- type III following its introduction was less easy to track, since serological testing would not have ...
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Development of Multiplex Real Time Reverse Transcriptase PCR Assays for Detecting Eight Medically Important Flaviviruses in Mosquitoes
... Flaviviruses are significant causes of disease worldwide and can be classified serologically into several antigenic complexes (12, 20). Medically important members of the Japanese en- cephalitis virus (JEV) serocomplex ...
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Hyperendemic dengue transmission and identification of a locally evolved DENV-3 lineage, Papua New Guinea 2007-2010
... more DENV serotypes and most sera neutralized all four DENV ...acute DENV infection in Madang, and clinic attendees in Lihir (predominantly women attending antenatal clinics) therefore these ...
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Effect of medicinal plants on Dengue: Review article
... pes DENV-1, DENV-2, DENV-3, and DENV-4 respectively, that spread by the bite of infected Aedes aegypti mosquito which is also known as Tiger ...
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The impact of Wolbachia infection on the rate of vertical transmission of dengue virus in Brazilian Aedes aegypti
... on DENV infection in Aedes aegypti ovaries. DENV prevalence and viral load in the ovaries of mosquitoes with (+Wolb, blue circles) and without (-Wolb, black circles) wMel Wolbachia ...with ...
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Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil
... a DENV-3 epidemic in early 2000 in central of Brazil ...a DENV-4 outbreak in 2013, which had the largest re- ported number of incident cases (2233 suspected cases per 100,000 inhabitants) at state ...
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Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China Myanmar Laos border, 2013–2015
... Dengue is a mosquito-borne disease caused by the dengue virus (DENV), which is transmitted by Aedes aegypti and Aedes albopictus mosquitoes that are present in most tropical and sub-tropical regions worldwide [1, ...
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Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect against Japanese Encephalitis Virus In Vitro and In Vivo
... However, DENV type-spe- cific and cross-reactive antibodies recently have been recov- ered from infected chimpanzees by repertoire ...A DENV-4-specific, highly neutralizing MAb (5H2) has been shown ...
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Competitive suppression of dengue virus replication occurs in chikungunya and dengue co infected Mexican infants
... The patients included in this study were enrolled at the Hospital General O’Horan Emergency Department dur- ing a two-week period in September 2015, at the height of the CHIKV outbreak in Yucatan. Patients presented ...
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Development of an Enzyme Linked Immunosorbent Assay for Rapid Detection of Dengue Virus (DENV) NS1 and Differentiation of DENV Serotypes during Early Infection
... of DENV infection were used to evaluate the clinical application of our novel test for the de- tection and serotyping of ...for DENV sero- type 1 (DENV1), ...for DENV NS1 is a convenient tool that ...
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